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Controlling the Substrate Specificity of an Enzyme through Structural Flexibility by Varying the Salt-Bridge Density
Many enzymes, particularly in one single family, with highly conserved structures and folds exhibit rather distinct substrate specificities. The underlying mechanism remains elusive, the resolution of which is of great importance for biochemistry, biophysics, and bioengineering. Here, we performed a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470667/ https://www.ncbi.nlm.nih.gov/pubmed/34577164 http://dx.doi.org/10.3390/molecules26185693 |