Improved HDAC Inhibition, Stronger Cytotoxic Effect and Higher Selectivity against Leukemias and Lymphomas of Novel, Tricyclic Vorinostat Analogues

Histone deacetylase (HDAC) inhibitors are a class of drugs used in the cancer treatment. Here, we developed a library of 19 analogues of Vorinostat, an HDAC inhibitor used in lymphomas treatment. In Vorinostat, we replaced the hydrophobic phenyl group with various tricyclic ‘caps’ possessing a centr...

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Detalles Bibliográficos
Autores principales: Bieszczad, Bartosz, Garbicz, Damian, Świtalska, Marta, Dudek, Marta K., Warszycki, Dawid, Wietrzyk, Joanna, Grzesiuk, Elżbieta, Mieczkowski, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470702/
https://www.ncbi.nlm.nih.gov/pubmed/34577551
http://dx.doi.org/10.3390/ph14090851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470702/
https://www.ncbi.nlm.nih.gov/pubmed/34577551
http://dx.doi.org/10.3390/ph14090851

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