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Native T(1) Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study
In this study, we investigated the utility of native T(1) mapping in differentiating between various grades of fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) in a rat model of CD. Bowel specimens (64) from 46 CD model rats undergoing native T(1) mapping and MTI...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470758/ https://www.ncbi.nlm.nih.gov/pubmed/34562892 http://dx.doi.org/10.3390/bios11090302 |
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author | Lu, Baolan Lin, Jinjiang Du, Jinfang He, Shaofu Cao, Qinghua Huang, Li Mao, Ren Sun, Canhui Li, Ziping Feng, Shiting Li, Xuehua |
author_facet | Lu, Baolan Lin, Jinjiang Du, Jinfang He, Shaofu Cao, Qinghua Huang, Li Mao, Ren Sun, Canhui Li, Ziping Feng, Shiting Li, Xuehua |
author_sort | Lu, Baolan |
collection | PubMed |
description | In this study, we investigated the utility of native T(1) mapping in differentiating between various grades of fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) in a rat model of CD. Bowel specimens (64) from 46 CD model rats undergoing native T(1) mapping and MTI were enrolled. The longitudinal relaxation time (T(1) value) and normalized magnetization transfer ratio (MTR) were compared between none-to-mild and moderate-to-severe fibrotic bowel walls confirmed by pathological assessments. The results showed that the correlation between the T(1) value and fibrosis (r = 0.438, p < 0.001) was lower than that between the normalized MTR and fibrosis (r = 0.623, p < 0.001). Overall, the T(1) values (t = −3.066, p = 0.004) and normalized MTRs (z = 0.081, p < 0.001) in none-to-mild fibrotic bowel walls were lower than those in moderate-to-severe fibrotic bowel walls. The area under the curve (AUC) of the T(1) value (AUC = 0.716, p = 0.004) was significantly lower than that of the normalized MTR (AUC = 0.881, p < 0.001) in differentiating moderate-to-severe fibrosis from none-to-mild fibrosis (z = −2.037, p = 0.042). Our results support the view that the T(1) value could be a promising imaging biomarker in grading the fibrosis severity of CD. However, the diagnostic performance of native T(1) mapping was not superior to MTI. |
format | Online Article Text |
id | pubmed-8470758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84707582021-09-27 Native T(1) Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study Lu, Baolan Lin, Jinjiang Du, Jinfang He, Shaofu Cao, Qinghua Huang, Li Mao, Ren Sun, Canhui Li, Ziping Feng, Shiting Li, Xuehua Biosensors (Basel) Article In this study, we investigated the utility of native T(1) mapping in differentiating between various grades of fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) in a rat model of CD. Bowel specimens (64) from 46 CD model rats undergoing native T(1) mapping and MTI were enrolled. The longitudinal relaxation time (T(1) value) and normalized magnetization transfer ratio (MTR) were compared between none-to-mild and moderate-to-severe fibrotic bowel walls confirmed by pathological assessments. The results showed that the correlation between the T(1) value and fibrosis (r = 0.438, p < 0.001) was lower than that between the normalized MTR and fibrosis (r = 0.623, p < 0.001). Overall, the T(1) values (t = −3.066, p = 0.004) and normalized MTRs (z = 0.081, p < 0.001) in none-to-mild fibrotic bowel walls were lower than those in moderate-to-severe fibrotic bowel walls. The area under the curve (AUC) of the T(1) value (AUC = 0.716, p = 0.004) was significantly lower than that of the normalized MTR (AUC = 0.881, p < 0.001) in differentiating moderate-to-severe fibrosis from none-to-mild fibrosis (z = −2.037, p = 0.042). Our results support the view that the T(1) value could be a promising imaging biomarker in grading the fibrosis severity of CD. However, the diagnostic performance of native T(1) mapping was not superior to MTI. MDPI 2021-08-28 /pmc/articles/PMC8470758/ /pubmed/34562892 http://dx.doi.org/10.3390/bios11090302 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lu, Baolan Lin, Jinjiang Du, Jinfang He, Shaofu Cao, Qinghua Huang, Li Mao, Ren Sun, Canhui Li, Ziping Feng, Shiting Li, Xuehua Native T(1) Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study |
title | Native T(1) Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study |
title_full | Native T(1) Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study |
title_fullStr | Native T(1) Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study |
title_full_unstemmed | Native T(1) Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study |
title_short | Native T(1) Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study |
title_sort | native t(1) mapping and magnetization transfer imaging in grading bowel fibrosis in crohn’s disease: a comparative animal study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470758/ https://www.ncbi.nlm.nih.gov/pubmed/34562892 http://dx.doi.org/10.3390/bios11090302 |
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