Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases

The adult Göttingen Minipig is an acknowledged model for safety assessment of antisense oligonucleotide (ASO) drugs developed for adult indications. To assess whether the juvenile Göttingen Minipig is also a suitable nonclinical model for pediatric safety assessment of ASOs, we performed an 8-week r...

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Detalles Bibliográficos
Autores principales: Valenzuela, Allan, Tardiveau, Claire, Ayuso, Miriam, Buyssens, Laura, Bars, Chloe, Van Ginneken, Chris, Fant, Pierluigi, Leconte, Isabelle, Braendli-Baiocco, Annamaria, Parrott, Neil, Schmitt, Georg, Tessier, Yann, Barrow, Paul, Van Cruchten, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470776/
https://www.ncbi.nlm.nih.gov/pubmed/34575518
http://dx.doi.org/10.3390/pharmaceutics13091442

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