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Pioglitazone Reverses Markers of Islet Beta-Cell De-Differentiation in db/db Mice While Modulating Expression of Genes Controlling Inflammation and Browning in White Adipose Tissue from Insulin-Resistant Mice and Humans

Obesity, insulin resistance, and type 2 diabetes contribute to increased morbidity and mortality in humans. The db/db mouse is an important mouse model that displays many key features of the human disease. Herein, we used the drug pioglitazone, a thiazolidinedione with insulin-sensitizing properties...

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Detalles Bibliográficos
Autores principales:	Collier, J. Jason, Batdorf, Heidi M., Merrifield, Kaelan L., Martin, Thomas M., White, Ursula, Ravussin, Eric, Burk, David H., Cooley, Chris R., Karlstad, Michael D., Burke, Susan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470788/ https://www.ncbi.nlm.nih.gov/pubmed/34572374 http://dx.doi.org/10.3390/biomedicines9091189

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