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Quality of Life and Psychological Disorders in Coeliac Disease: A Prospective Multicentre Study

Coeliac disease (CeD) has been associated with psychological disorders and reduced quality of life. Our prospective study evaluated the changes in the quality of life, anxiety and depression in CeD patients up to two years after diagnosis. We recruited adult patients residing in the Veneto region wi...

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Autores principales: Canova, Cristina, Rosato, Isabella, Marsilio, Ilaria, Valiante, Flavio, Zorzetto, Valerio, Cataudella, Giovanni, D’Odorico, Anna, Zingone, Fabiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470791/
https://www.ncbi.nlm.nih.gov/pubmed/34579108
http://dx.doi.org/10.3390/nu13093233
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author Canova, Cristina
Rosato, Isabella
Marsilio, Ilaria
Valiante, Flavio
Zorzetto, Valerio
Cataudella, Giovanni
D’Odorico, Anna
Zingone, Fabiana
author_facet Canova, Cristina
Rosato, Isabella
Marsilio, Ilaria
Valiante, Flavio
Zorzetto, Valerio
Cataudella, Giovanni
D’Odorico, Anna
Zingone, Fabiana
author_sort Canova, Cristina
collection PubMed
description Coeliac disease (CeD) has been associated with psychological disorders and reduced quality of life. Our prospective study evaluated the changes in the quality of life, anxiety and depression in CeD patients up to two years after diagnosis. We recruited adult patients residing in the Veneto region with a new diagnosis of CeD. Several validated questionnaires were administered to measure quality of life, psychological symptoms and adherence to a gluten-free diet (GFD) at the time of diagnosis and after 1 and 2 years. Ninety-three patients reached the 1-year follow-up (81.7% were females with a median age at diagnosis of 35 years), and 55 patients reached the 2-year follow-up. We observed a significant improvement in quality of life, anxiety and depression scores at 1 year after diagnosis, particularly in patients who complied with a GFD. The improvements among classical CeD patients were similar to those observed in nonclassical patients except for anxiety, which improved only in patients with a classical presentation at diagnosis. Age, sex and other disease factors did not affect the change in quality of life (QoL) or other mood disorders. Most of the improvements measured 1 year after diagnosis and 2 years after diagnosis were not significant. In conclusion, QoL and mood disorders must be considered, and psychological counselling should be used when needed.
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spelling pubmed-84707912021-09-27 Quality of Life and Psychological Disorders in Coeliac Disease: A Prospective Multicentre Study Canova, Cristina Rosato, Isabella Marsilio, Ilaria Valiante, Flavio Zorzetto, Valerio Cataudella, Giovanni D’Odorico, Anna Zingone, Fabiana Nutrients Article Coeliac disease (CeD) has been associated with psychological disorders and reduced quality of life. Our prospective study evaluated the changes in the quality of life, anxiety and depression in CeD patients up to two years after diagnosis. We recruited adult patients residing in the Veneto region with a new diagnosis of CeD. Several validated questionnaires were administered to measure quality of life, psychological symptoms and adherence to a gluten-free diet (GFD) at the time of diagnosis and after 1 and 2 years. Ninety-three patients reached the 1-year follow-up (81.7% were females with a median age at diagnosis of 35 years), and 55 patients reached the 2-year follow-up. We observed a significant improvement in quality of life, anxiety and depression scores at 1 year after diagnosis, particularly in patients who complied with a GFD. The improvements among classical CeD patients were similar to those observed in nonclassical patients except for anxiety, which improved only in patients with a classical presentation at diagnosis. Age, sex and other disease factors did not affect the change in quality of life (QoL) or other mood disorders. Most of the improvements measured 1 year after diagnosis and 2 years after diagnosis were not significant. In conclusion, QoL and mood disorders must be considered, and psychological counselling should be used when needed. MDPI 2021-09-16 /pmc/articles/PMC8470791/ /pubmed/34579108 http://dx.doi.org/10.3390/nu13093233 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Canova, Cristina
Rosato, Isabella
Marsilio, Ilaria
Valiante, Flavio
Zorzetto, Valerio
Cataudella, Giovanni
D’Odorico, Anna
Zingone, Fabiana
Quality of Life and Psychological Disorders in Coeliac Disease: A Prospective Multicentre Study
title Quality of Life and Psychological Disorders in Coeliac Disease: A Prospective Multicentre Study
title_full Quality of Life and Psychological Disorders in Coeliac Disease: A Prospective Multicentre Study
title_fullStr Quality of Life and Psychological Disorders in Coeliac Disease: A Prospective Multicentre Study
title_full_unstemmed Quality of Life and Psychological Disorders in Coeliac Disease: A Prospective Multicentre Study
title_short Quality of Life and Psychological Disorders in Coeliac Disease: A Prospective Multicentre Study
title_sort quality of life and psychological disorders in coeliac disease: a prospective multicentre study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470791/
https://www.ncbi.nlm.nih.gov/pubmed/34579108
http://dx.doi.org/10.3390/nu13093233
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