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Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological Drugs
Background and objectives: Biological treatment is an important and effective therapy for psoriasis. During the COVID-19 pandemic, it remains unclear whether this type of therapy affects the course of SARS-CoV-2 infection. The aim of the study was to observe patients with psoriasis undergoing biolog...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470849/ https://www.ncbi.nlm.nih.gov/pubmed/34577804 http://dx.doi.org/10.3390/medicina57090881 |
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author | Mroz, Magdalena Mućka, Szymon Miodońska, Martyna Ziolkowska, Dominika Hadas, Ewa Bożek, Andrzej |
author_facet | Mroz, Magdalena Mućka, Szymon Miodońska, Martyna Ziolkowska, Dominika Hadas, Ewa Bożek, Andrzej |
author_sort | Mroz, Magdalena |
collection | PubMed |
description | Background and objectives: Biological treatment is an important and effective therapy for psoriasis. During the COVID-19 pandemic, it remains unclear whether this type of therapy affects the course of SARS-CoV-2 infection. The aim of the study was to observe patients with psoriasis undergoing biological or other systemic treatment in relation to the impact of SARS-CoV-2 infection on the course of psoriasis and the COVID-19 disease itself. Materials and methods: A one-year observational study included 57 patients with diagnosed psoriasis who qualified for biological treatment and a group of 68 similar patients who were administered a different systemic treatment. Patients were analyzed monthly for psoriasis (including Psoriasis Area Severity Index (PASI) assessment) and constantly for SARS-CoV-2 infection (telephone contact). Cases of COVID-19 were confirmed by Polymerase Chain Reaction (PCR) at the study center. Results: SARS-CoV-2 infection was confirmed by a positive Real Time Polymerase Chain Reaction (RT-PCR) test in eight patients (14.0%) with psoriasis on biological therapy. None of the cases in this group required hospitalization for COVID-19. Similar data were obtained in the control group. Specifically, 11 (16%) patients were confirmed to be infected with SARS-CoV-2. These results were statistically comparable (p > 0.05). In the group of patients undergoing biological treatment, six (75%) of eight patients developed an exacerbation of psoriasis during SARS-CoV-2 infection, and similar results were noted in the control group, with eight (72%) patients experiencing an exacerbation of psoriasis. Conclusions: Patients with psoriasis who were administered biological treatment or other systemic therapy may experience a mild course of SARS-CoV-2 infection but might also experience a temporary exacerbation of skin lesions. |
format | Online Article Text |
id | pubmed-8470849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84708492021-09-27 Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological Drugs Mroz, Magdalena Mućka, Szymon Miodońska, Martyna Ziolkowska, Dominika Hadas, Ewa Bożek, Andrzej Medicina (Kaunas) Article Background and objectives: Biological treatment is an important and effective therapy for psoriasis. During the COVID-19 pandemic, it remains unclear whether this type of therapy affects the course of SARS-CoV-2 infection. The aim of the study was to observe patients with psoriasis undergoing biological or other systemic treatment in relation to the impact of SARS-CoV-2 infection on the course of psoriasis and the COVID-19 disease itself. Materials and methods: A one-year observational study included 57 patients with diagnosed psoriasis who qualified for biological treatment and a group of 68 similar patients who were administered a different systemic treatment. Patients were analyzed monthly for psoriasis (including Psoriasis Area Severity Index (PASI) assessment) and constantly for SARS-CoV-2 infection (telephone contact). Cases of COVID-19 were confirmed by Polymerase Chain Reaction (PCR) at the study center. Results: SARS-CoV-2 infection was confirmed by a positive Real Time Polymerase Chain Reaction (RT-PCR) test in eight patients (14.0%) with psoriasis on biological therapy. None of the cases in this group required hospitalization for COVID-19. Similar data were obtained in the control group. Specifically, 11 (16%) patients were confirmed to be infected with SARS-CoV-2. These results were statistically comparable (p > 0.05). In the group of patients undergoing biological treatment, six (75%) of eight patients developed an exacerbation of psoriasis during SARS-CoV-2 infection, and similar results were noted in the control group, with eight (72%) patients experiencing an exacerbation of psoriasis. Conclusions: Patients with psoriasis who were administered biological treatment or other systemic therapy may experience a mild course of SARS-CoV-2 infection but might also experience a temporary exacerbation of skin lesions. MDPI 2021-08-27 /pmc/articles/PMC8470849/ /pubmed/34577804 http://dx.doi.org/10.3390/medicina57090881 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mroz, Magdalena Mućka, Szymon Miodońska, Martyna Ziolkowska, Dominika Hadas, Ewa Bożek, Andrzej Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological Drugs |
title | Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological Drugs |
title_full | Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological Drugs |
title_fullStr | Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological Drugs |
title_full_unstemmed | Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological Drugs |
title_short | Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological Drugs |
title_sort | influence of sars-cov-2 virus infection on the course of psoriasis during treatment with biological drugs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470849/ https://www.ncbi.nlm.nih.gov/pubmed/34577804 http://dx.doi.org/10.3390/medicina57090881 |
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