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Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition

We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care...

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Autores principales: Arrieta, Francisco, Martinez-Vaello, Victoria, Bengoa, Nuria, Rosillo, Marta, de Pablo, Angélica, Voguel, Cristina, Pintor, Rosario, Belanger-Quintana, Amaya, Mateo-Lobo, Raquel, Candela, Angel, Botella-Carretero, José I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470880/
https://www.ncbi.nlm.nih.gov/pubmed/34578888
http://dx.doi.org/10.3390/nu13093010
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author Arrieta, Francisco
Martinez-Vaello, Victoria
Bengoa, Nuria
Rosillo, Marta
de Pablo, Angélica
Voguel, Cristina
Pintor, Rosario
Belanger-Quintana, Amaya
Mateo-Lobo, Raquel
Candela, Angel
Botella-Carretero, José I.
author_facet Arrieta, Francisco
Martinez-Vaello, Victoria
Bengoa, Nuria
Rosillo, Marta
de Pablo, Angélica
Voguel, Cristina
Pintor, Rosario
Belanger-Quintana, Amaya
Mateo-Lobo, Raquel
Candela, Angel
Botella-Carretero, José I.
author_sort Arrieta, Francisco
collection PubMed
description We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care unit (ICU), 26 with COVID-19 and 26 non-COVID-19, were included. Glycemic control, delivery of artificial nutrition, serum osteocalcin, total and ICU stays, and mortality were recorded. Patients with COVID-19 had higher ICU stays, were on artificial nutrition for longer (p = 0.004), and needed more frequently insulin infusion therapy (p = 0.022) to control stress hyperglycemia. The need for insulin infusion therapy was associated with higher energy (p = 0.001) and glucose delivered through artificial nutrition (p = 0.040). Those patients with stress hyperglycemia showed higher ICU stays (23 ± 17 vs. 11 ± 13 days, p = 0.007). Serum osteocalcin was a good marker for hyperglycemia, as it inversely correlated with glycemia at admission in the ICU (r = −0.476, p = 0.001) and at days 2 (r = −0.409, p = 0.007) and 3 (r = −0.351, p = 0.049). In conclusion, hyperglycemia in critically ill COVID-19 patients was associated with longer ICU stays. Low circulating osteocalcin was a good marker for stress hyperglycemia.
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spelling pubmed-84708802021-09-27 Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition Arrieta, Francisco Martinez-Vaello, Victoria Bengoa, Nuria Rosillo, Marta de Pablo, Angélica Voguel, Cristina Pintor, Rosario Belanger-Quintana, Amaya Mateo-Lobo, Raquel Candela, Angel Botella-Carretero, José I. Nutrients Article We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care unit (ICU), 26 with COVID-19 and 26 non-COVID-19, were included. Glycemic control, delivery of artificial nutrition, serum osteocalcin, total and ICU stays, and mortality were recorded. Patients with COVID-19 had higher ICU stays, were on artificial nutrition for longer (p = 0.004), and needed more frequently insulin infusion therapy (p = 0.022) to control stress hyperglycemia. The need for insulin infusion therapy was associated with higher energy (p = 0.001) and glucose delivered through artificial nutrition (p = 0.040). Those patients with stress hyperglycemia showed higher ICU stays (23 ± 17 vs. 11 ± 13 days, p = 0.007). Serum osteocalcin was a good marker for hyperglycemia, as it inversely correlated with glycemia at admission in the ICU (r = −0.476, p = 0.001) and at days 2 (r = −0.409, p = 0.007) and 3 (r = −0.351, p = 0.049). In conclusion, hyperglycemia in critically ill COVID-19 patients was associated with longer ICU stays. Low circulating osteocalcin was a good marker for stress hyperglycemia. MDPI 2021-08-28 /pmc/articles/PMC8470880/ /pubmed/34578888 http://dx.doi.org/10.3390/nu13093010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arrieta, Francisco
Martinez-Vaello, Victoria
Bengoa, Nuria
Rosillo, Marta
de Pablo, Angélica
Voguel, Cristina
Pintor, Rosario
Belanger-Quintana, Amaya
Mateo-Lobo, Raquel
Candela, Angel
Botella-Carretero, José I.
Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition
title Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition
title_full Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition
title_fullStr Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition
title_full_unstemmed Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition
title_short Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition
title_sort stress hyperglycemia and osteocalcin in covid-19 critically ill patients on artificial nutrition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470880/
https://www.ncbi.nlm.nih.gov/pubmed/34578888
http://dx.doi.org/10.3390/nu13093010
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