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Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition
We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470880/ https://www.ncbi.nlm.nih.gov/pubmed/34578888 http://dx.doi.org/10.3390/nu13093010 |
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author | Arrieta, Francisco Martinez-Vaello, Victoria Bengoa, Nuria Rosillo, Marta de Pablo, Angélica Voguel, Cristina Pintor, Rosario Belanger-Quintana, Amaya Mateo-Lobo, Raquel Candela, Angel Botella-Carretero, José I. |
author_facet | Arrieta, Francisco Martinez-Vaello, Victoria Bengoa, Nuria Rosillo, Marta de Pablo, Angélica Voguel, Cristina Pintor, Rosario Belanger-Quintana, Amaya Mateo-Lobo, Raquel Candela, Angel Botella-Carretero, José I. |
author_sort | Arrieta, Francisco |
collection | PubMed |
description | We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care unit (ICU), 26 with COVID-19 and 26 non-COVID-19, were included. Glycemic control, delivery of artificial nutrition, serum osteocalcin, total and ICU stays, and mortality were recorded. Patients with COVID-19 had higher ICU stays, were on artificial nutrition for longer (p = 0.004), and needed more frequently insulin infusion therapy (p = 0.022) to control stress hyperglycemia. The need for insulin infusion therapy was associated with higher energy (p = 0.001) and glucose delivered through artificial nutrition (p = 0.040). Those patients with stress hyperglycemia showed higher ICU stays (23 ± 17 vs. 11 ± 13 days, p = 0.007). Serum osteocalcin was a good marker for hyperglycemia, as it inversely correlated with glycemia at admission in the ICU (r = −0.476, p = 0.001) and at days 2 (r = −0.409, p = 0.007) and 3 (r = −0.351, p = 0.049). In conclusion, hyperglycemia in critically ill COVID-19 patients was associated with longer ICU stays. Low circulating osteocalcin was a good marker for stress hyperglycemia. |
format | Online Article Text |
id | pubmed-8470880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84708802021-09-27 Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition Arrieta, Francisco Martinez-Vaello, Victoria Bengoa, Nuria Rosillo, Marta de Pablo, Angélica Voguel, Cristina Pintor, Rosario Belanger-Quintana, Amaya Mateo-Lobo, Raquel Candela, Angel Botella-Carretero, José I. Nutrients Article We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. Fifty-two critical patients at the intensive care unit (ICU), 26 with COVID-19 and 26 non-COVID-19, were included. Glycemic control, delivery of artificial nutrition, serum osteocalcin, total and ICU stays, and mortality were recorded. Patients with COVID-19 had higher ICU stays, were on artificial nutrition for longer (p = 0.004), and needed more frequently insulin infusion therapy (p = 0.022) to control stress hyperglycemia. The need for insulin infusion therapy was associated with higher energy (p = 0.001) and glucose delivered through artificial nutrition (p = 0.040). Those patients with stress hyperglycemia showed higher ICU stays (23 ± 17 vs. 11 ± 13 days, p = 0.007). Serum osteocalcin was a good marker for hyperglycemia, as it inversely correlated with glycemia at admission in the ICU (r = −0.476, p = 0.001) and at days 2 (r = −0.409, p = 0.007) and 3 (r = −0.351, p = 0.049). In conclusion, hyperglycemia in critically ill COVID-19 patients was associated with longer ICU stays. Low circulating osteocalcin was a good marker for stress hyperglycemia. MDPI 2021-08-28 /pmc/articles/PMC8470880/ /pubmed/34578888 http://dx.doi.org/10.3390/nu13093010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Arrieta, Francisco Martinez-Vaello, Victoria Bengoa, Nuria Rosillo, Marta de Pablo, Angélica Voguel, Cristina Pintor, Rosario Belanger-Quintana, Amaya Mateo-Lobo, Raquel Candela, Angel Botella-Carretero, José I. Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition |
title | Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition |
title_full | Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition |
title_fullStr | Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition |
title_full_unstemmed | Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition |
title_short | Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition |
title_sort | stress hyperglycemia and osteocalcin in covid-19 critically ill patients on artificial nutrition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470880/ https://www.ncbi.nlm.nih.gov/pubmed/34578888 http://dx.doi.org/10.3390/nu13093010 |
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