Cargando…
Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children
Background and Objective: It is known that several viruses are involved in the pathogenesis of type 1 diabetes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new worldwide spread virus that may act as a trigger for the autoimmune destruction of the β-cells, as well, and thus lead...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470921/ https://www.ncbi.nlm.nih.gov/pubmed/34577896 http://dx.doi.org/10.3390/medicina57090973 |
_version_ | 1784574324017987584 |
---|---|
author | Vlad, Adrian Serban, Viorel Timar, Romulus Sima, Alexandra Botea, Veronica Albai, Oana Timar, Bogdan Vlad, Mihaela |
author_facet | Vlad, Adrian Serban, Viorel Timar, Romulus Sima, Alexandra Botea, Veronica Albai, Oana Timar, Bogdan Vlad, Mihaela |
author_sort | Vlad, Adrian |
collection | PubMed |
description | Background and Objective: It is known that several viruses are involved in the pathogenesis of type 1 diabetes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new worldwide spread virus that may act as a trigger for the autoimmune destruction of the β-cells, as well, and thus lead to an increase in the incidence of type 1 diabetes. Material and Methods: The Romanian National Organization for the Protection of Children and Adolescents with Diabetes (ONROCAD) has collected information regarding new cases of type 1 diabetes in children aged 0 to 14 years from all over the country since 1996 and has computed the incidence of type 1 diabetes in this age group. Results: We observed a marked increase in the incidence of type 1 diabetes in the first year of the COVID-19 pandemic, with 16.9%, from 11.4/100,000 in 2019 to 13.3/100,000 in 2020, much higher compared to previous years (mean yearly increase was 5.1% in the period 1996–2015 and 0.8% in the interval 2015–2019). The proportion of newly diagnosed cases was significantly higher in the second half of 2020 compared to the second half of the previous years (57.8 vs. 51%, p < 0.0001). Conclusions: All these aspects suggest the role that SARS-CoV-2 could have in triggering pancreatic autoimmunity. To confirm this, however, collecting information from larger populations from different geographical regions, monitoring the incidence curves over a period of several years, and gathering background information on COVID-19 and/or data on COVID-19 specific antibodies are needed. |
format | Online Article Text |
id | pubmed-8470921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84709212021-09-27 Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children Vlad, Adrian Serban, Viorel Timar, Romulus Sima, Alexandra Botea, Veronica Albai, Oana Timar, Bogdan Vlad, Mihaela Medicina (Kaunas) Article Background and Objective: It is known that several viruses are involved in the pathogenesis of type 1 diabetes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new worldwide spread virus that may act as a trigger for the autoimmune destruction of the β-cells, as well, and thus lead to an increase in the incidence of type 1 diabetes. Material and Methods: The Romanian National Organization for the Protection of Children and Adolescents with Diabetes (ONROCAD) has collected information regarding new cases of type 1 diabetes in children aged 0 to 14 years from all over the country since 1996 and has computed the incidence of type 1 diabetes in this age group. Results: We observed a marked increase in the incidence of type 1 diabetes in the first year of the COVID-19 pandemic, with 16.9%, from 11.4/100,000 in 2019 to 13.3/100,000 in 2020, much higher compared to previous years (mean yearly increase was 5.1% in the period 1996–2015 and 0.8% in the interval 2015–2019). The proportion of newly diagnosed cases was significantly higher in the second half of 2020 compared to the second half of the previous years (57.8 vs. 51%, p < 0.0001). Conclusions: All these aspects suggest the role that SARS-CoV-2 could have in triggering pancreatic autoimmunity. To confirm this, however, collecting information from larger populations from different geographical regions, monitoring the incidence curves over a period of several years, and gathering background information on COVID-19 and/or data on COVID-19 specific antibodies are needed. MDPI 2021-09-16 /pmc/articles/PMC8470921/ /pubmed/34577896 http://dx.doi.org/10.3390/medicina57090973 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vlad, Adrian Serban, Viorel Timar, Romulus Sima, Alexandra Botea, Veronica Albai, Oana Timar, Bogdan Vlad, Mihaela Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children |
title | Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children |
title_full | Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children |
title_fullStr | Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children |
title_full_unstemmed | Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children |
title_short | Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children |
title_sort | increased incidence of type 1 diabetes during the covid-19 pandemic in romanian children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470921/ https://www.ncbi.nlm.nih.gov/pubmed/34577896 http://dx.doi.org/10.3390/medicina57090973 |
work_keys_str_mv | AT vladadrian increasedincidenceoftype1diabetesduringthecovid19pandemicinromanianchildren AT serbanviorel increasedincidenceoftype1diabetesduringthecovid19pandemicinromanianchildren AT timarromulus increasedincidenceoftype1diabetesduringthecovid19pandemicinromanianchildren AT simaalexandra increasedincidenceoftype1diabetesduringthecovid19pandemicinromanianchildren AT boteaveronica increasedincidenceoftype1diabetesduringthecovid19pandemicinromanianchildren AT albaioana increasedincidenceoftype1diabetesduringthecovid19pandemicinromanianchildren AT timarbogdan increasedincidenceoftype1diabetesduringthecovid19pandemicinromanianchildren AT vladmihaela increasedincidenceoftype1diabetesduringthecovid19pandemicinromanianchildren |