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Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study

Background and Objectives: No data are available on whether the heritability of left ventricle (LV) systolic and diastolic parameters are independent of each other. Therefore, our aim was to assess the magnitude of common and independent genetic and environmental factors defining LV systolic and dia...

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Autores principales: Molnár, Andrea Ágnes, Kolossváry, Márton, Lakatos, Bálint, Tokodi, Márton, Tárnoki, Ádám Domonkos, Tárnoki, Dávid László, Kovács, Attila, Szilveszter, Bálint, Voros, Szilard, Jermendy, György, Maurovich-Horvat, Pál, Merkely, Béla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470958/
https://www.ncbi.nlm.nih.gov/pubmed/34577858
http://dx.doi.org/10.3390/medicina57090935
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author Molnár, Andrea Ágnes
Kolossváry, Márton
Lakatos, Bálint
Tokodi, Márton
Tárnoki, Ádám Domonkos
Tárnoki, Dávid László
Kovács, Attila
Szilveszter, Bálint
Voros, Szilard
Jermendy, György
Maurovich-Horvat, Pál
Merkely, Béla
author_facet Molnár, Andrea Ágnes
Kolossváry, Márton
Lakatos, Bálint
Tokodi, Márton
Tárnoki, Ádám Domonkos
Tárnoki, Dávid László
Kovács, Attila
Szilveszter, Bálint
Voros, Szilard
Jermendy, György
Maurovich-Horvat, Pál
Merkely, Béla
author_sort Molnár, Andrea Ágnes
collection PubMed
description Background and Objectives: No data are available on whether the heritability of left ventricle (LV) systolic and diastolic parameters are independent of each other. Therefore, our aim was to assess the magnitude of common and independent genetic and environmental factors defining LV systolic and diastolic function. Materials and Methods: We analyzed 184 asymptomatic twins (65% female, mean age: 56 ± 9 years). Transthoracic echocardiography was performed to measure LV systolic (global longitudinal and circumferential strain; basal and apical rotation) and diastolic (early diastolic velocity of mitral inflow and lateral mitral annulus tissue; deceleration time and early diastolic strain rate) parameters using conventional and speckle-tracking echocardiography. Genetic structural equation models were evaluated to quantify the proportion of common and specific genetic (Ac, As) and environmental factors (Ec, Es) contributing to the phenotypes. Results: LV systolic parameters had no common genetic or environmental heritability (Ac range: 0–0%; Ec range: 0–0%; As range: 57–77%; Es range: 24–43%). Diastolic LV parameters were mainly determined by common genetic and environmental effects (Ac range: 9–40%; Ec range: 11–49%; As range: 0–29%; Es range: 0–51%). Systolic parameters had no common genetic or environmental factors (Ac = 0%; Ec = 0%) with diastolic metrics. Conclusions: Systolic LV parameters have a strong genetic predisposition to any impact. They share no common genetic or environmental factors with each other or with diastolic parameters, indicating that they may deteriorate specifically to given effects. However, diastolic functional parameters are mainly affected by common environmental influences, suggesting that pathological conditions may deteriorate them equally. Estimation of the genetic and environmental influence and interdependence on systolic and diastolic LV function may help the understanding of the pathomechanism of different heart failure classification types.
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spelling pubmed-84709582021-09-27 Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study Molnár, Andrea Ágnes Kolossváry, Márton Lakatos, Bálint Tokodi, Márton Tárnoki, Ádám Domonkos Tárnoki, Dávid László Kovács, Attila Szilveszter, Bálint Voros, Szilard Jermendy, György Maurovich-Horvat, Pál Merkely, Béla Medicina (Kaunas) Article Background and Objectives: No data are available on whether the heritability of left ventricle (LV) systolic and diastolic parameters are independent of each other. Therefore, our aim was to assess the magnitude of common and independent genetic and environmental factors defining LV systolic and diastolic function. Materials and Methods: We analyzed 184 asymptomatic twins (65% female, mean age: 56 ± 9 years). Transthoracic echocardiography was performed to measure LV systolic (global longitudinal and circumferential strain; basal and apical rotation) and diastolic (early diastolic velocity of mitral inflow and lateral mitral annulus tissue; deceleration time and early diastolic strain rate) parameters using conventional and speckle-tracking echocardiography. Genetic structural equation models were evaluated to quantify the proportion of common and specific genetic (Ac, As) and environmental factors (Ec, Es) contributing to the phenotypes. Results: LV systolic parameters had no common genetic or environmental heritability (Ac range: 0–0%; Ec range: 0–0%; As range: 57–77%; Es range: 24–43%). Diastolic LV parameters were mainly determined by common genetic and environmental effects (Ac range: 9–40%; Ec range: 11–49%; As range: 0–29%; Es range: 0–51%). Systolic parameters had no common genetic or environmental factors (Ac = 0%; Ec = 0%) with diastolic metrics. Conclusions: Systolic LV parameters have a strong genetic predisposition to any impact. They share no common genetic or environmental factors with each other or with diastolic parameters, indicating that they may deteriorate specifically to given effects. However, diastolic functional parameters are mainly affected by common environmental influences, suggesting that pathological conditions may deteriorate them equally. Estimation of the genetic and environmental influence and interdependence on systolic and diastolic LV function may help the understanding of the pathomechanism of different heart failure classification types. MDPI 2021-09-05 /pmc/articles/PMC8470958/ /pubmed/34577858 http://dx.doi.org/10.3390/medicina57090935 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Molnár, Andrea Ágnes
Kolossváry, Márton
Lakatos, Bálint
Tokodi, Márton
Tárnoki, Ádám Domonkos
Tárnoki, Dávid László
Kovács, Attila
Szilveszter, Bálint
Voros, Szilard
Jermendy, György
Maurovich-Horvat, Pál
Merkely, Béla
Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study
title Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study
title_full Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study
title_fullStr Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study
title_full_unstemmed Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study
title_short Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study
title_sort left ventricular systolic function has strong independent genetic background from diastolic function: a classical twin study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470958/
https://www.ncbi.nlm.nih.gov/pubmed/34577858
http://dx.doi.org/10.3390/medicina57090935
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