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Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy

The selective disruption of nutritional supplements and the metabolic routes of cancer cells offer a promising opportunity for more efficient cancer therapeutics. Herein, a biomimetic cascade polymer nanoreactor (GOx/CAT-NC) was fabricated by encapsulating glucose oxidase (GOx) and catalase (CAT) in...

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Autores principales: Liu, Shengda, Yan, Tengfei, Sun, Jianxin, Li, Fei, Xu, Jiayun, Sun, Hongcheng, Yu, Shuangjiang, Liu, Junqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470963/
https://www.ncbi.nlm.nih.gov/pubmed/34577080
http://dx.doi.org/10.3390/molecules26185609
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author Liu, Shengda
Yan, Tengfei
Sun, Jianxin
Li, Fei
Xu, Jiayun
Sun, Hongcheng
Yu, Shuangjiang
Liu, Junqiu
author_facet Liu, Shengda
Yan, Tengfei
Sun, Jianxin
Li, Fei
Xu, Jiayun
Sun, Hongcheng
Yu, Shuangjiang
Liu, Junqiu
author_sort Liu, Shengda
collection PubMed
description The selective disruption of nutritional supplements and the metabolic routes of cancer cells offer a promising opportunity for more efficient cancer therapeutics. Herein, a biomimetic cascade polymer nanoreactor (GOx/CAT-NC) was fabricated by encapsulating glucose oxidase (GOx) and catalase (CAT) in a porphyrin polymer nanocapsule for combined starvation and photodynamic anticancer therapy. Internalized by cancer cells, the GOx/CAT-NCs facilitate microenvironmental oxidation by catalyzing endogenous H(2)O(2) to form O(2), thereby accelerating intracellular glucose catabolism and enhancing cytotoxic singlet oxygen ((1)O(2)) production with infrared irradiation. The GOx/CAT-NCs have demonstrated synergistic advantages in long-term starvation therapy and powerful photodynamic therapy (PDT) in cancer treatment, which inhibits tumor cells at more than twice the rate of starvation therapy alone. The biomimetic polymer nanoreactor will further contribute to the advancement of complementary modes of spatiotemporal control of cancer therapy.
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spelling pubmed-84709632021-09-27 Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy Liu, Shengda Yan, Tengfei Sun, Jianxin Li, Fei Xu, Jiayun Sun, Hongcheng Yu, Shuangjiang Liu, Junqiu Molecules Article The selective disruption of nutritional supplements and the metabolic routes of cancer cells offer a promising opportunity for more efficient cancer therapeutics. Herein, a biomimetic cascade polymer nanoreactor (GOx/CAT-NC) was fabricated by encapsulating glucose oxidase (GOx) and catalase (CAT) in a porphyrin polymer nanocapsule for combined starvation and photodynamic anticancer therapy. Internalized by cancer cells, the GOx/CAT-NCs facilitate microenvironmental oxidation by catalyzing endogenous H(2)O(2) to form O(2), thereby accelerating intracellular glucose catabolism and enhancing cytotoxic singlet oxygen ((1)O(2)) production with infrared irradiation. The GOx/CAT-NCs have demonstrated synergistic advantages in long-term starvation therapy and powerful photodynamic therapy (PDT) in cancer treatment, which inhibits tumor cells at more than twice the rate of starvation therapy alone. The biomimetic polymer nanoreactor will further contribute to the advancement of complementary modes of spatiotemporal control of cancer therapy. MDPI 2021-09-16 /pmc/articles/PMC8470963/ /pubmed/34577080 http://dx.doi.org/10.3390/molecules26185609 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Shengda
Yan, Tengfei
Sun, Jianxin
Li, Fei
Xu, Jiayun
Sun, Hongcheng
Yu, Shuangjiang
Liu, Junqiu
Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy
title Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy
title_full Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy
title_fullStr Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy
title_full_unstemmed Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy
title_short Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy
title_sort biomimetic cascade polymer nanoreactors for starvation and photodynamic cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470963/
https://www.ncbi.nlm.nih.gov/pubmed/34577080
http://dx.doi.org/10.3390/molecules26185609
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