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Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy
The selective disruption of nutritional supplements and the metabolic routes of cancer cells offer a promising opportunity for more efficient cancer therapeutics. Herein, a biomimetic cascade polymer nanoreactor (GOx/CAT-NC) was fabricated by encapsulating glucose oxidase (GOx) and catalase (CAT) in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470963/ https://www.ncbi.nlm.nih.gov/pubmed/34577080 http://dx.doi.org/10.3390/molecules26185609 |
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author | Liu, Shengda Yan, Tengfei Sun, Jianxin Li, Fei Xu, Jiayun Sun, Hongcheng Yu, Shuangjiang Liu, Junqiu |
author_facet | Liu, Shengda Yan, Tengfei Sun, Jianxin Li, Fei Xu, Jiayun Sun, Hongcheng Yu, Shuangjiang Liu, Junqiu |
author_sort | Liu, Shengda |
collection | PubMed |
description | The selective disruption of nutritional supplements and the metabolic routes of cancer cells offer a promising opportunity for more efficient cancer therapeutics. Herein, a biomimetic cascade polymer nanoreactor (GOx/CAT-NC) was fabricated by encapsulating glucose oxidase (GOx) and catalase (CAT) in a porphyrin polymer nanocapsule for combined starvation and photodynamic anticancer therapy. Internalized by cancer cells, the GOx/CAT-NCs facilitate microenvironmental oxidation by catalyzing endogenous H(2)O(2) to form O(2), thereby accelerating intracellular glucose catabolism and enhancing cytotoxic singlet oxygen ((1)O(2)) production with infrared irradiation. The GOx/CAT-NCs have demonstrated synergistic advantages in long-term starvation therapy and powerful photodynamic therapy (PDT) in cancer treatment, which inhibits tumor cells at more than twice the rate of starvation therapy alone. The biomimetic polymer nanoreactor will further contribute to the advancement of complementary modes of spatiotemporal control of cancer therapy. |
format | Online Article Text |
id | pubmed-8470963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84709632021-09-27 Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy Liu, Shengda Yan, Tengfei Sun, Jianxin Li, Fei Xu, Jiayun Sun, Hongcheng Yu, Shuangjiang Liu, Junqiu Molecules Article The selective disruption of nutritional supplements and the metabolic routes of cancer cells offer a promising opportunity for more efficient cancer therapeutics. Herein, a biomimetic cascade polymer nanoreactor (GOx/CAT-NC) was fabricated by encapsulating glucose oxidase (GOx) and catalase (CAT) in a porphyrin polymer nanocapsule for combined starvation and photodynamic anticancer therapy. Internalized by cancer cells, the GOx/CAT-NCs facilitate microenvironmental oxidation by catalyzing endogenous H(2)O(2) to form O(2), thereby accelerating intracellular glucose catabolism and enhancing cytotoxic singlet oxygen ((1)O(2)) production with infrared irradiation. The GOx/CAT-NCs have demonstrated synergistic advantages in long-term starvation therapy and powerful photodynamic therapy (PDT) in cancer treatment, which inhibits tumor cells at more than twice the rate of starvation therapy alone. The biomimetic polymer nanoreactor will further contribute to the advancement of complementary modes of spatiotemporal control of cancer therapy. MDPI 2021-09-16 /pmc/articles/PMC8470963/ /pubmed/34577080 http://dx.doi.org/10.3390/molecules26185609 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Shengda Yan, Tengfei Sun, Jianxin Li, Fei Xu, Jiayun Sun, Hongcheng Yu, Shuangjiang Liu, Junqiu Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy |
title | Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy |
title_full | Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy |
title_fullStr | Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy |
title_full_unstemmed | Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy |
title_short | Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy |
title_sort | biomimetic cascade polymer nanoreactors for starvation and photodynamic cancer therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470963/ https://www.ncbi.nlm.nih.gov/pubmed/34577080 http://dx.doi.org/10.3390/molecules26185609 |
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