Cargando…

The Splice of Life: Does RNA Processing Have a Role in HIV-1 Persistence?

Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure. However, these HIV-1 reservoirs are not transcriptionally silent, and viral transc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pasternak, Alexander O., Berkhout, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471011/ https://www.ncbi.nlm.nih.gov/pubmed/34578332 http://dx.doi.org/10.3390/v13091751

Ejemplares similares

Cell-associated HIV RNA: a dynamic biomarker of viral persistence
por: Pasternak, Alexander O, et al.
Publicado: (2013)

Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy
por: Scherpenisse, Mirte, et al.
Publicado: (2021)

The RNA structure of the major splice donor site controls HIV-1 splicing
por: Mueller, Nancy, et al.
Publicado: (2013)

Differences in HIV Markers between Infected Individuals Treated with Different ART Regimens: Implications for the Persistence of Viral Reservoirs
por: Darcis, Gilles, et al.
Publicado: (2020)

HIV-1 splicing is modulated by RNA structure
por: Müller, Nancy, et al.
Publicado: (2011)

Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter?
por: Pasternak, Alexander O., et al.
Publicado: (2021)

What do we measure when we measure cell-associated HIV RNA
por: Pasternak, Alexander O., et al.
Publicado: (2018)

A Phylogenetic Survey on the Structure of the HIV-1 Leader RNA Domain That Encodes the Splice Donor Signal
por: Mueller, Nancy, et al.
Publicado: (2016)

On the generation of the MSD-Ѱ class of defective HIV proviruses
por: Das, Atze T., et al.
Publicado: (2019)

Autologous T-cell therapy based on a lentiviral vector expressing long antisense RNA targeted against HIV-1 env gene influences HIV replication and evolution in vivo
por: Pasternak, Alexander, et al.
Publicado: (2013)

The Quest for Cellular Markers of HIV Reservoirs: Any Color You Like
por: Darcis, Gilles, et al.
Publicado: (2019)

Comparison of Droplet Digital PCR and Seminested Real-Time PCR for Quantification of Cell-Associated HIV-1 RNA
por: Kiselinova, Maja, et al.
Publicado: (2014)

On the role of four small hairpins in the HIV-1 RNA genome
por: Knoepfel, Stefanie A., et al.
Publicado: (2013)

Cellular Levels of HIV Unspliced RNA from Patients on Combination Antiretroviral Therapy with Undetectable Plasma Viremia Predict the Therapy Outcome
por: Pasternak, Alexander O., et al.
Publicado: (2009)

Role of HIV-1 RNA and protein determinants for the selective packaging of spliced and unspliced viral RNA and host U6 and 7SL RNA in virus particles
por: Didierlaurent, L., et al.
Publicado: (2011)

Tackling HIV Persistence: Pharmacological versus CRISPR-Based Shock Strategies
por: Darcis, Gilles, et al.
Publicado: (2018)

HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA
por: Namer, Lise Sarah, et al.
Publicado: (2023)

Circularization of the HIV-1 RNA genome
por: Ooms, Marcel, et al.
Publicado: (2007)

Phylogenetic screen for important RNA structure motifs in the HIV-1 genome
por: Knoepfel, Stefanie A, et al.
Publicado: (2011)

Determination of RNA structural diversity and its role in HIV-1 RNA splicing
por: Tomezsko, Phillip J., et al.
Publicado: (2020)

Modest deviations from optimal adherence to antiretroviral therapy promote residual HIV-1 replication in the absence of virological rebound in plasma
por: Pasternak, Alexander O, et al.
Publicado: (2011)

The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interference
por: Westerhout, Ellen M, et al.
Publicado: (2006)

Translational HIV-1 research: from routine diagnostics to new virology insights in Amsterdam, the Netherlands during 1983-2013
por: van der Kuyl, Antoinette C, et al.
Publicado: (2013)

In vivo SELEX of single-stranded domains in the HIV-1 leader RNA
por: van Bel, Nikki, et al.
Publicado: (2013)

Characterization of microRNAs derived from the HIV-1 TAR RNA hairpin
por: Harwig, Alex, et al.
Publicado: (2013)

Microprocessor-dependent processing of splice site overlapping microRNA exons does not result in changes in alternative splicing
por: Pianigiani, Giulia, et al.
Publicado: (2018)

Improvement of the CRISPR-Cpf1 system with ribozyme-processed crRNA
por: Gao, Zongliang, et al.
Publicado: (2018)

HIV-1 latency in activated T-cells
por: Berkhout, Ben
Publicado: (2013)

Novel AgoshRNA molecules for silencing of the CCR5 co-receptor for HIV-1 infection
por: Herrera-Carrillo, Elena, et al.
Publicado: (2017)

Hairpin-induced tRNA-mediated (HITME) recombination in HIV-1
por: Konstantinova, Pavlina, et al.
Publicado: (2006)

How Polypurine Tract Changes in the HIV-1 RNA Genome Can Cause Resistance against the Integrase Inhibitor Dolutegravir
por: Das, Atze T., et al.
Publicado: (2018)

The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packaging of a Functional RNA Genome
por: van Bel, Nikki, et al.
Publicado: (2014)

HIV-1: To Splice or Not to Splice, That Is the Question
por: Emery, Ann, et al.
Publicado: (2021)

HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome
por: Westerhout, Ellen M., et al.
Publicado: (2005)

General Anesthesia Does Not Have Persistent Effects on Attention in Rodents
por: Hambrecht-Wiedbusch, Viviane S., et al.
Publicado: (2019)

Dicer-independent processing of small RNA duplexes: mechanistic insights and applications
por: Herrera-Carrillo, Elena, et al.
Publicado: (2017)

Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging
por: Das, Atze T, et al.
Publicado: (2012)

A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs
por: ter Brake, Olivier, et al.
Publicado: (2005)

HIV-1 drug-resistance and drug-dependence
por: Baldwin, Chris, et al.
Publicado: (2007)

Tat-dependent production of an HIV-1 TAR-encoded miRNA-like small RNA
por: Harwig, Alex, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pc2gddgq4r000h68q86h5kif6g