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Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review
Background: Fetal growth restriction (FGR) is a pregnancy complication. Multiple studies have connected FGR to poor cognitive development, behavior disorders, and academic difficulties during childhood. Brain sparing has traditionally been defined as an adaptive phenomenon in which the brain obtains...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471063/ https://www.ncbi.nlm.nih.gov/pubmed/34572177 http://dx.doi.org/10.3390/children8090745 |
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author | Benítez-Marín, María José Marín-Clavijo, Jesús Blanco-Elena, Juan Antonio Jiménez-López, Jesús González-Mesa, Ernesto |
author_facet | Benítez-Marín, María José Marín-Clavijo, Jesús Blanco-Elena, Juan Antonio Jiménez-López, Jesús González-Mesa, Ernesto |
author_sort | Benítez-Marín, María José |
collection | PubMed |
description | Background: Fetal growth restriction (FGR) is a pregnancy complication. Multiple studies have connected FGR to poor cognitive development, behavior disorders, and academic difficulties during childhood. Brain sparing has traditionally been defined as an adaptive phenomenon in which the brain obtains the blood flow that it needs. However, this adaptive phenomenon might not have a complete protective effect. This publication aims to systematically review the consequences of brain redistribution on neurodevelopment in children who presented with placental intrauterine growth restriction. Methods: We performed a systematic review according to PRISMA guidelines. It included studies on intrauterine growth restriction or small-for-gestational-age (SGA) fetuses, which middle cerebral artery was measured, and neurodevelopment assessed during childhood. PUBMED and EMBASE databases were searched for relevant published studies. Results: Of the 526 studies reviewed, only 12 were included. Brain sparing was associated with poor cognitive function and lower scores in IQ. Cerebral redistribution was related to better executive function and better behavior at 4 years old but not at 12 years old. Conclusions: We can assume that fetal brain sparing could not be a fully protective phenomenon. We could not find clinical differences in behavioral and executive functions because the results were heterogeneous. Some cognitive abilities could be affected in FGR brain sparing fetuses. |
format | Online Article Text |
id | pubmed-8471063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84710632021-09-27 Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review Benítez-Marín, María José Marín-Clavijo, Jesús Blanco-Elena, Juan Antonio Jiménez-López, Jesús González-Mesa, Ernesto Children (Basel) Systematic Review Background: Fetal growth restriction (FGR) is a pregnancy complication. Multiple studies have connected FGR to poor cognitive development, behavior disorders, and academic difficulties during childhood. Brain sparing has traditionally been defined as an adaptive phenomenon in which the brain obtains the blood flow that it needs. However, this adaptive phenomenon might not have a complete protective effect. This publication aims to systematically review the consequences of brain redistribution on neurodevelopment in children who presented with placental intrauterine growth restriction. Methods: We performed a systematic review according to PRISMA guidelines. It included studies on intrauterine growth restriction or small-for-gestational-age (SGA) fetuses, which middle cerebral artery was measured, and neurodevelopment assessed during childhood. PUBMED and EMBASE databases were searched for relevant published studies. Results: Of the 526 studies reviewed, only 12 were included. Brain sparing was associated with poor cognitive function and lower scores in IQ. Cerebral redistribution was related to better executive function and better behavior at 4 years old but not at 12 years old. Conclusions: We can assume that fetal brain sparing could not be a fully protective phenomenon. We could not find clinical differences in behavioral and executive functions because the results were heterogeneous. Some cognitive abilities could be affected in FGR brain sparing fetuses. MDPI 2021-08-28 /pmc/articles/PMC8471063/ /pubmed/34572177 http://dx.doi.org/10.3390/children8090745 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Benítez-Marín, María José Marín-Clavijo, Jesús Blanco-Elena, Juan Antonio Jiménez-López, Jesús González-Mesa, Ernesto Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review |
title | Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review |
title_full | Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review |
title_fullStr | Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review |
title_full_unstemmed | Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review |
title_short | Brain Sparing Effect on Neurodevelopment in Children with Intrauterine Growth Restriction: A Systematic Review |
title_sort | brain sparing effect on neurodevelopment in children with intrauterine growth restriction: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471063/ https://www.ncbi.nlm.nih.gov/pubmed/34572177 http://dx.doi.org/10.3390/children8090745 |
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