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Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort
Amino acids, fatty acids, and acylcarnitine metabolites play a pivotal role in maternal and fetal health, but profiles of these metabolites over pregnancy are not completely established. We described longitudinal trajectories of targeted amino acids, fatty acids, and acylcarnitines in pregnancy. We...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471130/ https://www.ncbi.nlm.nih.gov/pubmed/34578958 http://dx.doi.org/10.3390/nu13093080 |
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author | Mitro, Susanna D. Wu, Jing Rahman, Mohammad L. Cao, Yaqi Zhu, Yeyi Chen, Zhen Chen, Liwei Li, Mengying Hinkle, Stefanie N. Bremer, Andrew A. Weir, Natalie L. Tsai, Michael Y. Song, Yiqing Grantz, Katherine L. Gelaye, Bizu Zhang, Cuilin |
author_facet | Mitro, Susanna D. Wu, Jing Rahman, Mohammad L. Cao, Yaqi Zhu, Yeyi Chen, Zhen Chen, Liwei Li, Mengying Hinkle, Stefanie N. Bremer, Andrew A. Weir, Natalie L. Tsai, Michael Y. Song, Yiqing Grantz, Katherine L. Gelaye, Bizu Zhang, Cuilin |
author_sort | Mitro, Susanna D. |
collection | PubMed |
description | Amino acids, fatty acids, and acylcarnitine metabolites play a pivotal role in maternal and fetal health, but profiles of these metabolites over pregnancy are not completely established. We described longitudinal trajectories of targeted amino acids, fatty acids, and acylcarnitines in pregnancy. We quantified 102 metabolites and combinations (37 fatty acids, 37 amino acids, and 28 acylcarnitines) in plasma samples from pregnant women in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies—Singletons cohort (n = 214 women at 10–14 and 15–26 weeks, 107 at 26–31 weeks, and 103 at 33–39 weeks). We used linear mixed models to estimate metabolite trajectories and examined variation by body mass index (BMI), race/ethnicity, and fetal sex. After excluding largely undetected metabolites, we analyzed 77 metabolites and combinations. Levels of 13 of 15 acylcarnitines, 7 of 25 amino acids, and 18 of 37 fatty acids significantly declined over gestation, while 8 of 25 amino acids and 10 of 37 fatty acids significantly increased. Several trajectories appeared to differ by BMI, race/ethnicity, and fetal sex although no tests for interactions remained significant after multiple testing correction. Future studies merit longitudinal measurements to capture metabolite changes in pregnancy, and larger samples to examine modifying effects of maternal and fetal characteristics. |
format | Online Article Text |
id | pubmed-8471130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84711302021-09-27 Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort Mitro, Susanna D. Wu, Jing Rahman, Mohammad L. Cao, Yaqi Zhu, Yeyi Chen, Zhen Chen, Liwei Li, Mengying Hinkle, Stefanie N. Bremer, Andrew A. Weir, Natalie L. Tsai, Michael Y. Song, Yiqing Grantz, Katherine L. Gelaye, Bizu Zhang, Cuilin Nutrients Article Amino acids, fatty acids, and acylcarnitine metabolites play a pivotal role in maternal and fetal health, but profiles of these metabolites over pregnancy are not completely established. We described longitudinal trajectories of targeted amino acids, fatty acids, and acylcarnitines in pregnancy. We quantified 102 metabolites and combinations (37 fatty acids, 37 amino acids, and 28 acylcarnitines) in plasma samples from pregnant women in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies—Singletons cohort (n = 214 women at 10–14 and 15–26 weeks, 107 at 26–31 weeks, and 103 at 33–39 weeks). We used linear mixed models to estimate metabolite trajectories and examined variation by body mass index (BMI), race/ethnicity, and fetal sex. After excluding largely undetected metabolites, we analyzed 77 metabolites and combinations. Levels of 13 of 15 acylcarnitines, 7 of 25 amino acids, and 18 of 37 fatty acids significantly declined over gestation, while 8 of 25 amino acids and 10 of 37 fatty acids significantly increased. Several trajectories appeared to differ by BMI, race/ethnicity, and fetal sex although no tests for interactions remained significant after multiple testing correction. Future studies merit longitudinal measurements to capture metabolite changes in pregnancy, and larger samples to examine modifying effects of maternal and fetal characteristics. MDPI 2021-09-01 /pmc/articles/PMC8471130/ /pubmed/34578958 http://dx.doi.org/10.3390/nu13093080 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mitro, Susanna D. Wu, Jing Rahman, Mohammad L. Cao, Yaqi Zhu, Yeyi Chen, Zhen Chen, Liwei Li, Mengying Hinkle, Stefanie N. Bremer, Andrew A. Weir, Natalie L. Tsai, Michael Y. Song, Yiqing Grantz, Katherine L. Gelaye, Bizu Zhang, Cuilin Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort |
title | Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort |
title_full | Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort |
title_fullStr | Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort |
title_full_unstemmed | Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort |
title_short | Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort |
title_sort | longitudinal plasma metabolomics profile in pregnancy—a study in an ethnically diverse u.s. pregnancy cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471130/ https://www.ncbi.nlm.nih.gov/pubmed/34578958 http://dx.doi.org/10.3390/nu13093080 |
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