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Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort

Amino acids, fatty acids, and acylcarnitine metabolites play a pivotal role in maternal and fetal health, but profiles of these metabolites over pregnancy are not completely established. We described longitudinal trajectories of targeted amino acids, fatty acids, and acylcarnitines in pregnancy. We...

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Autores principales: Mitro, Susanna D., Wu, Jing, Rahman, Mohammad L., Cao, Yaqi, Zhu, Yeyi, Chen, Zhen, Chen, Liwei, Li, Mengying, Hinkle, Stefanie N., Bremer, Andrew A., Weir, Natalie L., Tsai, Michael Y., Song, Yiqing, Grantz, Katherine L., Gelaye, Bizu, Zhang, Cuilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471130/
https://www.ncbi.nlm.nih.gov/pubmed/34578958
http://dx.doi.org/10.3390/nu13093080
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author Mitro, Susanna D.
Wu, Jing
Rahman, Mohammad L.
Cao, Yaqi
Zhu, Yeyi
Chen, Zhen
Chen, Liwei
Li, Mengying
Hinkle, Stefanie N.
Bremer, Andrew A.
Weir, Natalie L.
Tsai, Michael Y.
Song, Yiqing
Grantz, Katherine L.
Gelaye, Bizu
Zhang, Cuilin
author_facet Mitro, Susanna D.
Wu, Jing
Rahman, Mohammad L.
Cao, Yaqi
Zhu, Yeyi
Chen, Zhen
Chen, Liwei
Li, Mengying
Hinkle, Stefanie N.
Bremer, Andrew A.
Weir, Natalie L.
Tsai, Michael Y.
Song, Yiqing
Grantz, Katherine L.
Gelaye, Bizu
Zhang, Cuilin
author_sort Mitro, Susanna D.
collection PubMed
description Amino acids, fatty acids, and acylcarnitine metabolites play a pivotal role in maternal and fetal health, but profiles of these metabolites over pregnancy are not completely established. We described longitudinal trajectories of targeted amino acids, fatty acids, and acylcarnitines in pregnancy. We quantified 102 metabolites and combinations (37 fatty acids, 37 amino acids, and 28 acylcarnitines) in plasma samples from pregnant women in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies—Singletons cohort (n = 214 women at 10–14 and 15–26 weeks, 107 at 26–31 weeks, and 103 at 33–39 weeks). We used linear mixed models to estimate metabolite trajectories and examined variation by body mass index (BMI), race/ethnicity, and fetal sex. After excluding largely undetected metabolites, we analyzed 77 metabolites and combinations. Levels of 13 of 15 acylcarnitines, 7 of 25 amino acids, and 18 of 37 fatty acids significantly declined over gestation, while 8 of 25 amino acids and 10 of 37 fatty acids significantly increased. Several trajectories appeared to differ by BMI, race/ethnicity, and fetal sex although no tests for interactions remained significant after multiple testing correction. Future studies merit longitudinal measurements to capture metabolite changes in pregnancy, and larger samples to examine modifying effects of maternal and fetal characteristics.
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spelling pubmed-84711302021-09-27 Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort Mitro, Susanna D. Wu, Jing Rahman, Mohammad L. Cao, Yaqi Zhu, Yeyi Chen, Zhen Chen, Liwei Li, Mengying Hinkle, Stefanie N. Bremer, Andrew A. Weir, Natalie L. Tsai, Michael Y. Song, Yiqing Grantz, Katherine L. Gelaye, Bizu Zhang, Cuilin Nutrients Article Amino acids, fatty acids, and acylcarnitine metabolites play a pivotal role in maternal and fetal health, but profiles of these metabolites over pregnancy are not completely established. We described longitudinal trajectories of targeted amino acids, fatty acids, and acylcarnitines in pregnancy. We quantified 102 metabolites and combinations (37 fatty acids, 37 amino acids, and 28 acylcarnitines) in plasma samples from pregnant women in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies—Singletons cohort (n = 214 women at 10–14 and 15–26 weeks, 107 at 26–31 weeks, and 103 at 33–39 weeks). We used linear mixed models to estimate metabolite trajectories and examined variation by body mass index (BMI), race/ethnicity, and fetal sex. After excluding largely undetected metabolites, we analyzed 77 metabolites and combinations. Levels of 13 of 15 acylcarnitines, 7 of 25 amino acids, and 18 of 37 fatty acids significantly declined over gestation, while 8 of 25 amino acids and 10 of 37 fatty acids significantly increased. Several trajectories appeared to differ by BMI, race/ethnicity, and fetal sex although no tests for interactions remained significant after multiple testing correction. Future studies merit longitudinal measurements to capture metabolite changes in pregnancy, and larger samples to examine modifying effects of maternal and fetal characteristics. MDPI 2021-09-01 /pmc/articles/PMC8471130/ /pubmed/34578958 http://dx.doi.org/10.3390/nu13093080 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mitro, Susanna D.
Wu, Jing
Rahman, Mohammad L.
Cao, Yaqi
Zhu, Yeyi
Chen, Zhen
Chen, Liwei
Li, Mengying
Hinkle, Stefanie N.
Bremer, Andrew A.
Weir, Natalie L.
Tsai, Michael Y.
Song, Yiqing
Grantz, Katherine L.
Gelaye, Bizu
Zhang, Cuilin
Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort
title Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort
title_full Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort
title_fullStr Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort
title_full_unstemmed Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort
title_short Longitudinal Plasma Metabolomics Profile in Pregnancy—A Study in an Ethnically Diverse U.S. Pregnancy Cohort
title_sort longitudinal plasma metabolomics profile in pregnancy—a study in an ethnically diverse u.s. pregnancy cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471130/
https://www.ncbi.nlm.nih.gov/pubmed/34578958
http://dx.doi.org/10.3390/nu13093080
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