Promoter Hypermethylation Promotes the Binding of Transcription Factor NFATc1, Triggering Oncogenic Gene Activation in Pancreatic Cancer

SIMPLE SUMMARY: High promoter methylation is not necessarily associated with shutting down gene activity but does sometimes correlate with increased transcription instead. In a genome-wide analysis, we studied gene regulation in pancreatic cancer. We identified a substantial number of genes with bot...

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Detalles Bibliográficos
Autores principales: Wu, Yenan, Kröller, Lea, Miao, Beiping, Boekhoff, Henning, Bauer, Andrea S., Büchler, Markus W., Hackert, Thilo, Giese, Nathalia A., Taipale, Jussi, Hoheisel, Jörg D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471171/
https://www.ncbi.nlm.nih.gov/pubmed/34572796
http://dx.doi.org/10.3390/cancers13184569

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