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Exocytosis in Astrocytes
Until recently, astrocytes were thought to be a part of a simple “brain glue” providing only a supporting role for neurons. However, the discoveries of the last two decades have proven astrocytes to be dynamic partners participating in brain metabolism and actively influencing communication between...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471187/ https://www.ncbi.nlm.nih.gov/pubmed/34572580 http://dx.doi.org/10.3390/biom11091367 |
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author | Mielnicka, Aleksandra Michaluk, Piotr |
author_facet | Mielnicka, Aleksandra Michaluk, Piotr |
author_sort | Mielnicka, Aleksandra |
collection | PubMed |
description | Until recently, astrocytes were thought to be a part of a simple “brain glue” providing only a supporting role for neurons. However, the discoveries of the last two decades have proven astrocytes to be dynamic partners participating in brain metabolism and actively influencing communication between neurons. The means of astrocyte-neuron communication are diverse, although regulated exocytosis has received the most attention but also caused the most debate. Similar to most of eukaryotic cells, astrocytes have a complex range of vesicular organelles which can undergo exocytosis as well as intricate molecular mechanisms that regulate this process. In this review, we focus on the components needed for regulated exocytosis to occur and summarise the knowledge about experimental evidence showing its presence in astrocytes. |
format | Online Article Text |
id | pubmed-8471187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84711872021-09-27 Exocytosis in Astrocytes Mielnicka, Aleksandra Michaluk, Piotr Biomolecules Review Until recently, astrocytes were thought to be a part of a simple “brain glue” providing only a supporting role for neurons. However, the discoveries of the last two decades have proven astrocytes to be dynamic partners participating in brain metabolism and actively influencing communication between neurons. The means of astrocyte-neuron communication are diverse, although regulated exocytosis has received the most attention but also caused the most debate. Similar to most of eukaryotic cells, astrocytes have a complex range of vesicular organelles which can undergo exocytosis as well as intricate molecular mechanisms that regulate this process. In this review, we focus on the components needed for regulated exocytosis to occur and summarise the knowledge about experimental evidence showing its presence in astrocytes. MDPI 2021-09-16 /pmc/articles/PMC8471187/ /pubmed/34572580 http://dx.doi.org/10.3390/biom11091367 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mielnicka, Aleksandra Michaluk, Piotr Exocytosis in Astrocytes |
title | Exocytosis in Astrocytes |
title_full | Exocytosis in Astrocytes |
title_fullStr | Exocytosis in Astrocytes |
title_full_unstemmed | Exocytosis in Astrocytes |
title_short | Exocytosis in Astrocytes |
title_sort | exocytosis in astrocytes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471187/ https://www.ncbi.nlm.nih.gov/pubmed/34572580 http://dx.doi.org/10.3390/biom11091367 |
work_keys_str_mv | AT mielnickaaleksandra exocytosisinastrocytes AT michalukpiotr exocytosisinastrocytes |