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Exocytosis in Astrocytes

Until recently, astrocytes were thought to be a part of a simple “brain glue” providing only a supporting role for neurons. However, the discoveries of the last two decades have proven astrocytes to be dynamic partners participating in brain metabolism and actively influencing communication between...

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Detalles Bibliográficos
Autores principales: Mielnicka, Aleksandra, Michaluk, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471187/
https://www.ncbi.nlm.nih.gov/pubmed/34572580
http://dx.doi.org/10.3390/biom11091367
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author Mielnicka, Aleksandra
Michaluk, Piotr
author_facet Mielnicka, Aleksandra
Michaluk, Piotr
author_sort Mielnicka, Aleksandra
collection PubMed
description Until recently, astrocytes were thought to be a part of a simple “brain glue” providing only a supporting role for neurons. However, the discoveries of the last two decades have proven astrocytes to be dynamic partners participating in brain metabolism and actively influencing communication between neurons. The means of astrocyte-neuron communication are diverse, although regulated exocytosis has received the most attention but also caused the most debate. Similar to most of eukaryotic cells, astrocytes have a complex range of vesicular organelles which can undergo exocytosis as well as intricate molecular mechanisms that regulate this process. In this review, we focus on the components needed for regulated exocytosis to occur and summarise the knowledge about experimental evidence showing its presence in astrocytes.
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spelling pubmed-84711872021-09-27 Exocytosis in Astrocytes Mielnicka, Aleksandra Michaluk, Piotr Biomolecules Review Until recently, astrocytes were thought to be a part of a simple “brain glue” providing only a supporting role for neurons. However, the discoveries of the last two decades have proven astrocytes to be dynamic partners participating in brain metabolism and actively influencing communication between neurons. The means of astrocyte-neuron communication are diverse, although regulated exocytosis has received the most attention but also caused the most debate. Similar to most of eukaryotic cells, astrocytes have a complex range of vesicular organelles which can undergo exocytosis as well as intricate molecular mechanisms that regulate this process. In this review, we focus on the components needed for regulated exocytosis to occur and summarise the knowledge about experimental evidence showing its presence in astrocytes. MDPI 2021-09-16 /pmc/articles/PMC8471187/ /pubmed/34572580 http://dx.doi.org/10.3390/biom11091367 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mielnicka, Aleksandra
Michaluk, Piotr
Exocytosis in Astrocytes
title Exocytosis in Astrocytes
title_full Exocytosis in Astrocytes
title_fullStr Exocytosis in Astrocytes
title_full_unstemmed Exocytosis in Astrocytes
title_short Exocytosis in Astrocytes
title_sort exocytosis in astrocytes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471187/
https://www.ncbi.nlm.nih.gov/pubmed/34572580
http://dx.doi.org/10.3390/biom11091367
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