Activated Alpha 2-Macroglobulin Is a Novel Mediator of Mesangial Cell Profibrotic Signaling in Diabetic Kidney Disease

Diabetic kidney disease (DKD) is caused by the overproduction of extracellular matrix proteins (ECM) by glomerular mesangial cells (MCs). We previously showed that high glucose (HG) induces cell surface translocation of GRP78 (csGRP78), mediating PI3K/Akt activation and downstream ECM production. Ac...

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Detalles Bibliográficos
Autores principales: Trink, Jackie, Li, Renzhong, Palarasah, Yaseelan, Troyanov, Stéphan, Andersen, Thomas E., Sidelmann, Johannes J., Inman, Mark D., Pizzo, Salvatore V., Gao, Bo, Krepinsky, Joan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471248/
https://www.ncbi.nlm.nih.gov/pubmed/34572299
http://dx.doi.org/10.3390/biomedicines9091112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471248/
https://www.ncbi.nlm.nih.gov/pubmed/34572299
http://dx.doi.org/10.3390/biomedicines9091112

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