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Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration?
Migraine is the third most common condition worldwide and is responsible for a major clinical and economic burden. The current pilot trial investigated whether ketogenic diet therapy (KDT) is superior to an evidence-informed healthy “anti-headache” dietary pattern (AHD) in improving migraine frequen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471252/ https://www.ncbi.nlm.nih.gov/pubmed/34574879 http://dx.doi.org/10.3390/healthcare9091105 |
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author | Haslam, Rebecca L. Bezzina, Aaron Herbert, Jaimee Spratt, Neil Rollo, Megan E. Collins, Clare E. |
author_facet | Haslam, Rebecca L. Bezzina, Aaron Herbert, Jaimee Spratt, Neil Rollo, Megan E. Collins, Clare E. |
author_sort | Haslam, Rebecca L. |
collection | PubMed |
description | Migraine is the third most common condition worldwide and is responsible for a major clinical and economic burden. The current pilot trial investigated whether ketogenic diet therapy (KDT) is superior to an evidence-informed healthy “anti-headache” dietary pattern (AHD) in improving migraine frequency, severity and duration. A 12-week randomised controlled crossover trial consisting of the two dietary intervention periods was undertaken. Eligible participants were those with a history of migraines and who had regularly experienced episodes of moderate or mildly intense headache in the previous 4 weeks. Migraine frequency, duration and severity were assessed via self-report in the Migraine Buddy© app. Participants were asked to measure urinary ketones and side effects throughout the KDT. Twenty-six participants were enrolled, and 16 participants completed all sessions. Eleven participants completed a symptom checklist; all reported side-effects during KDT, with the most frequently reported side effect being fatigue (n = 11). All completers experienced migraine during AHD, with 14/16 experiencing migraine during KDT. Differences in migraine frequency, severity or duration between dietary intervention groups were not statistically significant. However, a clinically important trend toward lower migraine duration on KDT was noted. Further research in this area is warranted, with strategies to lower participant burden and promote adherence and retention. |
format | Online Article Text |
id | pubmed-8471252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84712522021-09-27 Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration? Haslam, Rebecca L. Bezzina, Aaron Herbert, Jaimee Spratt, Neil Rollo, Megan E. Collins, Clare E. Healthcare (Basel) Article Migraine is the third most common condition worldwide and is responsible for a major clinical and economic burden. The current pilot trial investigated whether ketogenic diet therapy (KDT) is superior to an evidence-informed healthy “anti-headache” dietary pattern (AHD) in improving migraine frequency, severity and duration. A 12-week randomised controlled crossover trial consisting of the two dietary intervention periods was undertaken. Eligible participants were those with a history of migraines and who had regularly experienced episodes of moderate or mildly intense headache in the previous 4 weeks. Migraine frequency, duration and severity were assessed via self-report in the Migraine Buddy© app. Participants were asked to measure urinary ketones and side effects throughout the KDT. Twenty-six participants were enrolled, and 16 participants completed all sessions. Eleven participants completed a symptom checklist; all reported side-effects during KDT, with the most frequently reported side effect being fatigue (n = 11). All completers experienced migraine during AHD, with 14/16 experiencing migraine during KDT. Differences in migraine frequency, severity or duration between dietary intervention groups were not statistically significant. However, a clinically important trend toward lower migraine duration on KDT was noted. Further research in this area is warranted, with strategies to lower participant burden and promote adherence and retention. MDPI 2021-08-26 /pmc/articles/PMC8471252/ /pubmed/34574879 http://dx.doi.org/10.3390/healthcare9091105 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Haslam, Rebecca L. Bezzina, Aaron Herbert, Jaimee Spratt, Neil Rollo, Megan E. Collins, Clare E. Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration? |
title | Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration? |
title_full | Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration? |
title_fullStr | Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration? |
title_full_unstemmed | Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration? |
title_short | Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration? |
title_sort | can ketogenic diet therapy improve migraine frequency, severity and duration? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471252/ https://www.ncbi.nlm.nih.gov/pubmed/34574879 http://dx.doi.org/10.3390/healthcare9091105 |
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