HBV and HDV: New Treatments on the Horizon

Despite the accumulating knowledge, chronic hepatitis B (CHB) and HDV infection represent a global health problem, and there are still several critical issues, which frequently remain uncovered. In this paper, we provided an overview of the current therapeutic options and summarized the investigatio...

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Autores principales: Zuccaro, Valentina, Asperges, Erika, Colaneri, Marta, Marvulli, Lea Nadia, Bruno, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471459/
https://www.ncbi.nlm.nih.gov/pubmed/34575165
http://dx.doi.org/10.3390/jcm10184054
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author Zuccaro, Valentina
Asperges, Erika
Colaneri, Marta
Marvulli, Lea Nadia
Bruno, Raffaele
author_facet Zuccaro, Valentina
Asperges, Erika
Colaneri, Marta
Marvulli, Lea Nadia
Bruno, Raffaele
author_sort Zuccaro, Valentina
collection PubMed
description Despite the accumulating knowledge, chronic hepatitis B (CHB) and HDV infection represent a global health problem, and there are still several critical issues, which frequently remain uncovered. In this paper, we provided an overview of the current therapeutic options and summarized the investigational therapies in the pipeline. Furthermore, we discussed some critical issues such as a “functional cure” approach, the futility of long-term NA therapy and the relevance of understanding drug actions and safety of antivirals, especially in special populations.
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spelling pubmed-84714592021-09-28 HBV and HDV: New Treatments on the Horizon Zuccaro, Valentina Asperges, Erika Colaneri, Marta Marvulli, Lea Nadia Bruno, Raffaele J Clin Med Review Despite the accumulating knowledge, chronic hepatitis B (CHB) and HDV infection represent a global health problem, and there are still several critical issues, which frequently remain uncovered. In this paper, we provided an overview of the current therapeutic options and summarized the investigational therapies in the pipeline. Furthermore, we discussed some critical issues such as a “functional cure” approach, the futility of long-term NA therapy and the relevance of understanding drug actions and safety of antivirals, especially in special populations. MDPI 2021-09-08 /pmc/articles/PMC8471459/ /pubmed/34575165 http://dx.doi.org/10.3390/jcm10184054 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zuccaro, Valentina
Asperges, Erika
Colaneri, Marta
Marvulli, Lea Nadia
Bruno, Raffaele
HBV and HDV: New Treatments on the Horizon
title HBV and HDV: New Treatments on the Horizon
title_full HBV and HDV: New Treatments on the Horizon
title_fullStr HBV and HDV: New Treatments on the Horizon
title_full_unstemmed HBV and HDV: New Treatments on the Horizon
title_short HBV and HDV: New Treatments on the Horizon
title_sort hbv and hdv: new treatments on the horizon
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471459/
https://www.ncbi.nlm.nih.gov/pubmed/34575165
http://dx.doi.org/10.3390/jcm10184054
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