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Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs

Female dogs, especially intact or neutered lately, are at increased risk for reproductive disorders including mammary tumors (MTs). This retrospective study evaluated the prevalence of reproductive pathology and associated mortality in a cohort of female dogs presented at a single veterinary clinic....

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Autores principales: Beaudu-Lange, Claire, Larrat, Sylvain, Lange, Emmanuel, Lecoq, Kevin, Nguyen, Frédérique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471467/
https://www.ncbi.nlm.nih.gov/pubmed/34564579
http://dx.doi.org/10.3390/vetsci8090184
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author Beaudu-Lange, Claire
Larrat, Sylvain
Lange, Emmanuel
Lecoq, Kevin
Nguyen, Frédérique
author_facet Beaudu-Lange, Claire
Larrat, Sylvain
Lange, Emmanuel
Lecoq, Kevin
Nguyen, Frédérique
author_sort Beaudu-Lange, Claire
collection PubMed
description Female dogs, especially intact or neutered lately, are at increased risk for reproductive disorders including mammary tumors (MTs). This retrospective study evaluated the prevalence of reproductive pathology and associated mortality in a cohort of female dogs presented at a single veterinary clinic. The medical records of female dogs born in 2000–2003 were reviewed. The study included 599 cases, of which 293 were followed up until death. Causes of death were analyzed according to the spaying status. Among the 599 female dogs, 306 were intact (51%), 50 (8%) had been spayed before 2 years of age (ES, early spaying), and 243 (41%) after 2 years (LS, late spaying). During their lifetime, 79 dogs (13.2%) developed pyometra, and 160 (26.7%) a mammary tumor. Among the 293 dogs with complete follow-up, 103 (35.1%) had at least one MT during their lifetime, of which 53 (51.5%) died of their mammary cancer. Spayed (ES + LS) female dogs had a 4-fold decreased risk of dying from mammary cancer (OR = 0.23, 95% CI 0.11–0.47, p < 0.0001) compared to intact females. In this low-sterilization rate population, MTs developed in 35.1% of female dogs over their lifetime and was the cause of death in half of them.
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spelling pubmed-84714672021-09-28 Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs Beaudu-Lange, Claire Larrat, Sylvain Lange, Emmanuel Lecoq, Kevin Nguyen, Frédérique Vet Sci Article Female dogs, especially intact or neutered lately, are at increased risk for reproductive disorders including mammary tumors (MTs). This retrospective study evaluated the prevalence of reproductive pathology and associated mortality in a cohort of female dogs presented at a single veterinary clinic. The medical records of female dogs born in 2000–2003 were reviewed. The study included 599 cases, of which 293 were followed up until death. Causes of death were analyzed according to the spaying status. Among the 599 female dogs, 306 were intact (51%), 50 (8%) had been spayed before 2 years of age (ES, early spaying), and 243 (41%) after 2 years (LS, late spaying). During their lifetime, 79 dogs (13.2%) developed pyometra, and 160 (26.7%) a mammary tumor. Among the 293 dogs with complete follow-up, 103 (35.1%) had at least one MT during their lifetime, of which 53 (51.5%) died of their mammary cancer. Spayed (ES + LS) female dogs had a 4-fold decreased risk of dying from mammary cancer (OR = 0.23, 95% CI 0.11–0.47, p < 0.0001) compared to intact females. In this low-sterilization rate population, MTs developed in 35.1% of female dogs over their lifetime and was the cause of death in half of them. MDPI 2021-09-04 /pmc/articles/PMC8471467/ /pubmed/34564579 http://dx.doi.org/10.3390/vetsci8090184 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beaudu-Lange, Claire
Larrat, Sylvain
Lange, Emmanuel
Lecoq, Kevin
Nguyen, Frédérique
Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs
title Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs
title_full Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs
title_fullStr Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs
title_full_unstemmed Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs
title_short Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs
title_sort prevalence of reproductive disorders including mammary tumors and associated mortality in female dogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471467/
https://www.ncbi.nlm.nih.gov/pubmed/34564579
http://dx.doi.org/10.3390/vetsci8090184
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