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Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19
Background and Objectives. The importance of mitochondria in inflammatory pathologies, besides providing energy, is associated with the release of mitochondrial damage products, such as mitochondrial DNA (mt-DNA), which may perpetuate inflammation. In this review, we aimed to show the importance of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471487/ https://www.ncbi.nlm.nih.gov/pubmed/34577851 http://dx.doi.org/10.3390/medicina57090928 |
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author | Valdés-Aguayo, José J. Garza-Veloz, Idalia Badillo-Almaráz, José I. Bernal-Silva, Sofia Martínez-Vázquez, Maria C. Juárez-Alcalá, Vladimir Vargas-Rodríguez, José R. Gaeta-Velasco, María L. González-Fuentes, Carolina Ávila-Carrasco, Lorena Martinez-Fierro, Margarita L. |
author_facet | Valdés-Aguayo, José J. Garza-Veloz, Idalia Badillo-Almaráz, José I. Bernal-Silva, Sofia Martínez-Vázquez, Maria C. Juárez-Alcalá, Vladimir Vargas-Rodríguez, José R. Gaeta-Velasco, María L. González-Fuentes, Carolina Ávila-Carrasco, Lorena Martinez-Fierro, Margarita L. |
author_sort | Valdés-Aguayo, José J. |
collection | PubMed |
description | Background and Objectives. The importance of mitochondria in inflammatory pathologies, besides providing energy, is associated with the release of mitochondrial damage products, such as mitochondrial DNA (mt-DNA), which may perpetuate inflammation. In this review, we aimed to show the importance of mitochondria, as organelles that produce energy and intervene in multiple pathologies, focusing mainly in COVID-19 and using multiple molecular mechanisms that allow for the replication and maintenance of the viral genome, leading to the exacerbation and spread of the inflammatory response. The evidence suggests that mitochondria are implicated in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which forms double-membrane vesicles and evades detection by the cell defense system. These mitochondrion-hijacking vesicles damage the integrity of the mitochondrion’s membrane, releasing mt-DNA into circulation and triggering the activation of innate immunity, which may contribute to an exacerbation of the pro-inflammatory state. Conclusions. While mitochondrial dysfunction in COVID-19 continues to be studied, the use of mt-DNA as an indicator of prognosis and severity is a potential area yet to be explored. |
format | Online Article Text |
id | pubmed-8471487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84714872021-09-28 Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19 Valdés-Aguayo, José J. Garza-Veloz, Idalia Badillo-Almaráz, José I. Bernal-Silva, Sofia Martínez-Vázquez, Maria C. Juárez-Alcalá, Vladimir Vargas-Rodríguez, José R. Gaeta-Velasco, María L. González-Fuentes, Carolina Ávila-Carrasco, Lorena Martinez-Fierro, Margarita L. Medicina (Kaunas) Review Background and Objectives. The importance of mitochondria in inflammatory pathologies, besides providing energy, is associated with the release of mitochondrial damage products, such as mitochondrial DNA (mt-DNA), which may perpetuate inflammation. In this review, we aimed to show the importance of mitochondria, as organelles that produce energy and intervene in multiple pathologies, focusing mainly in COVID-19 and using multiple molecular mechanisms that allow for the replication and maintenance of the viral genome, leading to the exacerbation and spread of the inflammatory response. The evidence suggests that mitochondria are implicated in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which forms double-membrane vesicles and evades detection by the cell defense system. These mitochondrion-hijacking vesicles damage the integrity of the mitochondrion’s membrane, releasing mt-DNA into circulation and triggering the activation of innate immunity, which may contribute to an exacerbation of the pro-inflammatory state. Conclusions. While mitochondrial dysfunction in COVID-19 continues to be studied, the use of mt-DNA as an indicator of prognosis and severity is a potential area yet to be explored. MDPI 2021-09-03 /pmc/articles/PMC8471487/ /pubmed/34577851 http://dx.doi.org/10.3390/medicina57090928 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Valdés-Aguayo, José J. Garza-Veloz, Idalia Badillo-Almaráz, José I. Bernal-Silva, Sofia Martínez-Vázquez, Maria C. Juárez-Alcalá, Vladimir Vargas-Rodríguez, José R. Gaeta-Velasco, María L. González-Fuentes, Carolina Ávila-Carrasco, Lorena Martinez-Fierro, Margarita L. Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19 |
title | Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19 |
title_full | Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19 |
title_fullStr | Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19 |
title_full_unstemmed | Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19 |
title_short | Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19 |
title_sort | mitochondria and mitochondrial dna: key elements in the pathogenesis and exacerbation of the inflammatory state caused by covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471487/ https://www.ncbi.nlm.nih.gov/pubmed/34577851 http://dx.doi.org/10.3390/medicina57090928 |
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