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Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs

Current epilepsy surgery planning protocol determines the seizure onset zone (SOZ) through resource-intensive, invasive monitoring of ictal events. Recently, we have reported that Granger Causality (GC) maps produced from analysis of interictal iEEG recordings have potential in revealing SOZ. In thi...

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Autores principales: Yang, Victor B., Madsen, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471554/
https://www.ncbi.nlm.nih.gov/pubmed/34573188
http://dx.doi.org/10.3390/brainsci11091167
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author Yang, Victor B.
Madsen, Joseph R.
author_facet Yang, Victor B.
Madsen, Joseph R.
author_sort Yang, Victor B.
collection PubMed
description Current epilepsy surgery planning protocol determines the seizure onset zone (SOZ) through resource-intensive, invasive monitoring of ictal events. Recently, we have reported that Granger Causality (GC) maps produced from analysis of interictal iEEG recordings have potential in revealing SOZ. In this study, we investigate GC maps’ network connectivity patterns to determine possible clinical correlation with patients’ SOZ and resection zone (RZ). While building understanding of interictal network topography and its relationship to the RZ/SOZ, we identify algorithmic tools with potential applications in epilepsy surgery planning. These graph algorithms are retrospectively tested on data from 25 patients and compared to the neurologist-determined SOZ and surgical RZ, viewed as sources of truth. Centrality algorithms yielded statistically significant RZ rank order sums for 16 of 24 patients with RZ data, representing an improvement from prior algorithms. While SOZ results remained largely the same, this study validates the applicability of graph algorithms to RZ/SOZ detection, opening the door to further exploration of iEEG datasets. Furthermore, this study offers previously inaccessible insights into the relationship between interictal brain connectivity patterns and epileptic brain networks, utilizing the overall topology of the graphs as well as data on edge weights and quantity of edges contained in GC maps.
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spelling pubmed-84715542021-09-28 Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs Yang, Victor B. Madsen, Joseph R. Brain Sci Article Current epilepsy surgery planning protocol determines the seizure onset zone (SOZ) through resource-intensive, invasive monitoring of ictal events. Recently, we have reported that Granger Causality (GC) maps produced from analysis of interictal iEEG recordings have potential in revealing SOZ. In this study, we investigate GC maps’ network connectivity patterns to determine possible clinical correlation with patients’ SOZ and resection zone (RZ). While building understanding of interictal network topography and its relationship to the RZ/SOZ, we identify algorithmic tools with potential applications in epilepsy surgery planning. These graph algorithms are retrospectively tested on data from 25 patients and compared to the neurologist-determined SOZ and surgical RZ, viewed as sources of truth. Centrality algorithms yielded statistically significant RZ rank order sums for 16 of 24 patients with RZ data, representing an improvement from prior algorithms. While SOZ results remained largely the same, this study validates the applicability of graph algorithms to RZ/SOZ detection, opening the door to further exploration of iEEG datasets. Furthermore, this study offers previously inaccessible insights into the relationship between interictal brain connectivity patterns and epileptic brain networks, utilizing the overall topology of the graphs as well as data on edge weights and quantity of edges contained in GC maps. MDPI 2021-09-01 /pmc/articles/PMC8471554/ /pubmed/34573188 http://dx.doi.org/10.3390/brainsci11091167 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Victor B.
Madsen, Joseph R.
Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs
title Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs
title_full Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs
title_fullStr Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs
title_full_unstemmed Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs
title_short Extensions of Granger Causality Calculations on Brain Networks for Efficient and Accurate Seizure Focus Identification via iEEGs
title_sort extensions of granger causality calculations on brain networks for efficient and accurate seizure focus identification via ieegs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471554/
https://www.ncbi.nlm.nih.gov/pubmed/34573188
http://dx.doi.org/10.3390/brainsci11091167
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