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Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis

Sarcoidosis is a systemic, granulomatous disease caused by unknown immunological abnormalities. The organs most vulnerable to sarcoidosis are the lungs. Patients often resolve spontaneously, but the lungs can also be severely affected. Although details regarding prognostic factors in sarcoidosis pat...

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Autores principales: Kotetsu, Yasuaki, Yanagihara, Toyoshi, Suzuki, Kunihiro, Ando, Hiroyuki, Eto, Daisuke, Hata, Kentaro, Arimura-Omori, Masako, Yamamoto, Yuzo, Harada, Eiji, Hamada, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471595/
https://www.ncbi.nlm.nih.gov/pubmed/34572417
http://dx.doi.org/10.3390/biomedicines9091231
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author Kotetsu, Yasuaki
Yanagihara, Toyoshi
Suzuki, Kunihiro
Ando, Hiroyuki
Eto, Daisuke
Hata, Kentaro
Arimura-Omori, Masako
Yamamoto, Yuzo
Harada, Eiji
Hamada, Naoki
author_facet Kotetsu, Yasuaki
Yanagihara, Toyoshi
Suzuki, Kunihiro
Ando, Hiroyuki
Eto, Daisuke
Hata, Kentaro
Arimura-Omori, Masako
Yamamoto, Yuzo
Harada, Eiji
Hamada, Naoki
author_sort Kotetsu, Yasuaki
collection PubMed
description Sarcoidosis is a systemic, granulomatous disease caused by unknown immunological abnormalities. The organs most vulnerable to sarcoidosis are the lungs. Patients often resolve spontaneously, but the lungs can also be severely affected. Although details regarding prognostic factors in sarcoidosis patients with lung involvement remain unclear, several reports have suggested that immune checkpoint molecules are involved in the pathogenesis of sarcoidosis. In this study, we divided sarcoidosis patients into two groups based on chest computed tomography (CT) findings and compared immune checkpoint molecules expressed on T cells in bronchoalveolar lavage fluid (BALF) in the two groups, using flow cytometry. We found elevated programmed cell death 1 (PD-1) or T cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) expression on T cells in BALF in patients with spontaneous improvement in CT findings, compared with those in patients without improvement in CT findings. In conclusion, our study implies that PD-1 or TIM-3 expression on T cells in BALF may be a prognostic factor for pulmonary lesions in sarcoidosis.
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spelling pubmed-84715952021-09-28 Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis Kotetsu, Yasuaki Yanagihara, Toyoshi Suzuki, Kunihiro Ando, Hiroyuki Eto, Daisuke Hata, Kentaro Arimura-Omori, Masako Yamamoto, Yuzo Harada, Eiji Hamada, Naoki Biomedicines Article Sarcoidosis is a systemic, granulomatous disease caused by unknown immunological abnormalities. The organs most vulnerable to sarcoidosis are the lungs. Patients often resolve spontaneously, but the lungs can also be severely affected. Although details regarding prognostic factors in sarcoidosis patients with lung involvement remain unclear, several reports have suggested that immune checkpoint molecules are involved in the pathogenesis of sarcoidosis. In this study, we divided sarcoidosis patients into two groups based on chest computed tomography (CT) findings and compared immune checkpoint molecules expressed on T cells in bronchoalveolar lavage fluid (BALF) in the two groups, using flow cytometry. We found elevated programmed cell death 1 (PD-1) or T cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) expression on T cells in BALF in patients with spontaneous improvement in CT findings, compared with those in patients without improvement in CT findings. In conclusion, our study implies that PD-1 or TIM-3 expression on T cells in BALF may be a prognostic factor for pulmonary lesions in sarcoidosis. MDPI 2021-09-16 /pmc/articles/PMC8471595/ /pubmed/34572417 http://dx.doi.org/10.3390/biomedicines9091231 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kotetsu, Yasuaki
Yanagihara, Toyoshi
Suzuki, Kunihiro
Ando, Hiroyuki
Eto, Daisuke
Hata, Kentaro
Arimura-Omori, Masako
Yamamoto, Yuzo
Harada, Eiji
Hamada, Naoki
Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis
title Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis
title_full Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis
title_fullStr Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis
title_full_unstemmed Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis
title_short Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis
title_sort imaging changes and immune-checkpoint expression on t cells in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471595/
https://www.ncbi.nlm.nih.gov/pubmed/34572417
http://dx.doi.org/10.3390/biomedicines9091231
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