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Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg)

Background: Bacterial antibiotic resistance changes over time depending on multiple factors; therefore, it is essential to monitor the susceptibility trends to reduce the resistance impact on the effectiveness of various treatments. Objective: To conduct a time-trend analysis of Helicobacter pylori...

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Autores principales: Bujanda, Luis, Nyssen, Olga P., Vaira, Dino, Saracino, Ilaria M., Fiorini, Giulia, Lerang, Frode, Georgopoulos, Sotirios, Tepes, Bojan, Heluwaert, Frederic, Gasbarrini, Antonio, Rokkas, Theodore, Bordin, Dmitry, Smith, Sinead, Lamy, Vincent, Caldas, María, Resina, Elena, Muñoz, Raquel, Cosme, Ángel, Puig, Ignasi, Megraud, Francis, O’Morain, Colm, Gisbert, Javier P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471667/
https://www.ncbi.nlm.nih.gov/pubmed/34572640
http://dx.doi.org/10.3390/antibiotics10091058
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author Bujanda, Luis
Nyssen, Olga P.
Vaira, Dino
Saracino, Ilaria M.
Fiorini, Giulia
Lerang, Frode
Georgopoulos, Sotirios
Tepes, Bojan
Heluwaert, Frederic
Gasbarrini, Antonio
Rokkas, Theodore
Bordin, Dmitry
Smith, Sinead
Lamy, Vincent
Caldas, María
Resina, Elena
Muñoz, Raquel
Cosme, Ángel
Puig, Ignasi
Megraud, Francis
O’Morain, Colm
Gisbert, Javier P.
author_facet Bujanda, Luis
Nyssen, Olga P.
Vaira, Dino
Saracino, Ilaria M.
Fiorini, Giulia
Lerang, Frode
Georgopoulos, Sotirios
Tepes, Bojan
Heluwaert, Frederic
Gasbarrini, Antonio
Rokkas, Theodore
Bordin, Dmitry
Smith, Sinead
Lamy, Vincent
Caldas, María
Resina, Elena
Muñoz, Raquel
Cosme, Ángel
Puig, Ignasi
Megraud, Francis
O’Morain, Colm
Gisbert, Javier P.
author_sort Bujanda, Luis
collection PubMed
description Background: Bacterial antibiotic resistance changes over time depending on multiple factors; therefore, it is essential to monitor the susceptibility trends to reduce the resistance impact on the effectiveness of various treatments. Objective: To conduct a time-trend analysis of Helicobacter pylori resistance to antibiotics in Europe. Methods: The international prospective European Registry on Helicobacter pylori Management (Hp-EuReg) collected data on all infected adult patients diagnosed with culture and antimicrobial susceptibility testing positive results that were registered at AEG-REDCap e-CRF until December 2020. Results: Overall, 41,562 patients were included in the Hp-EuReg. Culture and antimicrobial susceptibility testing were performed on gastric biopsies of 3974 (9.5%) patients, of whom 2852 (7%) were naive cases included for analysis. The number of positive cultures decreased by 35% from the period 2013–2016 to 2017–2020. Concerning naïve patients, no antibiotic resistance was found in 48% of the cases. The most frequent resistances were reported against metronidazole (30%), clarithromycin (25%), and levofloxacin (20%), whereas resistances to tetracycline and amoxicillin were below 1%. Dual and triple resistances were found in 13% and 6% of the cases, respectively. A decrease (p < 0.001) in the metronidazole resistance rate was observed between the 2013–2016 (33%) and 2017–2020 (24%) periods. Conclusion: Culture and antimicrobial susceptibility testing for Helicobacter pylori are scarcely performed (<10%) in Europe. In naïve patients, Helicobacter pylori resistance to clarithromycin remained above 15% throughout the period 2013–2020 and resistance to levofloxacin, as well as dual or triple resistances, were high. A progressive decrease in metronidazole resistance was observed.
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spelling pubmed-84716672021-09-28 Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg) Bujanda, Luis Nyssen, Olga P. Vaira, Dino Saracino, Ilaria M. Fiorini, Giulia Lerang, Frode Georgopoulos, Sotirios Tepes, Bojan Heluwaert, Frederic Gasbarrini, Antonio Rokkas, Theodore Bordin, Dmitry Smith, Sinead Lamy, Vincent Caldas, María Resina, Elena Muñoz, Raquel Cosme, Ángel Puig, Ignasi Megraud, Francis O’Morain, Colm Gisbert, Javier P. Antibiotics (Basel) Article Background: Bacterial antibiotic resistance changes over time depending on multiple factors; therefore, it is essential to monitor the susceptibility trends to reduce the resistance impact on the effectiveness of various treatments. Objective: To conduct a time-trend analysis of Helicobacter pylori resistance to antibiotics in Europe. Methods: The international prospective European Registry on Helicobacter pylori Management (Hp-EuReg) collected data on all infected adult patients diagnosed with culture and antimicrobial susceptibility testing positive results that were registered at AEG-REDCap e-CRF until December 2020. Results: Overall, 41,562 patients were included in the Hp-EuReg. Culture and antimicrobial susceptibility testing were performed on gastric biopsies of 3974 (9.5%) patients, of whom 2852 (7%) were naive cases included for analysis. The number of positive cultures decreased by 35% from the period 2013–2016 to 2017–2020. Concerning naïve patients, no antibiotic resistance was found in 48% of the cases. The most frequent resistances were reported against metronidazole (30%), clarithromycin (25%), and levofloxacin (20%), whereas resistances to tetracycline and amoxicillin were below 1%. Dual and triple resistances were found in 13% and 6% of the cases, respectively. A decrease (p < 0.001) in the metronidazole resistance rate was observed between the 2013–2016 (33%) and 2017–2020 (24%) periods. Conclusion: Culture and antimicrobial susceptibility testing for Helicobacter pylori are scarcely performed (<10%) in Europe. In naïve patients, Helicobacter pylori resistance to clarithromycin remained above 15% throughout the period 2013–2020 and resistance to levofloxacin, as well as dual or triple resistances, were high. A progressive decrease in metronidazole resistance was observed. MDPI 2021-09-01 /pmc/articles/PMC8471667/ /pubmed/34572640 http://dx.doi.org/10.3390/antibiotics10091058 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bujanda, Luis
Nyssen, Olga P.
Vaira, Dino
Saracino, Ilaria M.
Fiorini, Giulia
Lerang, Frode
Georgopoulos, Sotirios
Tepes, Bojan
Heluwaert, Frederic
Gasbarrini, Antonio
Rokkas, Theodore
Bordin, Dmitry
Smith, Sinead
Lamy, Vincent
Caldas, María
Resina, Elena
Muñoz, Raquel
Cosme, Ángel
Puig, Ignasi
Megraud, Francis
O’Morain, Colm
Gisbert, Javier P.
Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg)
title Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg)
title_full Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg)
title_fullStr Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg)
title_full_unstemmed Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg)
title_short Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg)
title_sort antibiotic resistance prevalence and trends in patients infected with helicobacter pylori in the period 2013–2020: results of the european registry on h. pylori management (hp-eureg)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471667/
https://www.ncbi.nlm.nih.gov/pubmed/34572640
http://dx.doi.org/10.3390/antibiotics10091058
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