Cargando…

CXCR1/2 Inhibitor Ladarixin Ameliorates the Insulin Resistance of 3T3-L1 Adipocytes by Inhibiting Inflammation and Improving Insulin Signaling

Type 2 diabetes mellitus is a severe public health issue worldwide. It displays a harmful effect on different organs as the eyes, kidneys and neural cells due to insulin resistance and high blood glucose concentrations. To date, the available treatments for this disorder remain limited. Several repo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castelli, Vanessa, Brandolini, Laura, d’Angelo, Michele, Giorgio, Cristina, Alfonsetti, Margherita, Cocchiaro, Pasquale, Lombardi, Francesca, Cimini, Annamaria, Allegretti, Marcello
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471705/ https://www.ncbi.nlm.nih.gov/pubmed/34571976 http://dx.doi.org/10.3390/cells10092324

Ejemplares similares

CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice
por: Mattos, Matheus Silverio, et al.
Publicado: (2020)

Differential Effects of Nonsteroidal Anti-Inflammatory Drugs in an In Vitro Model of Human Leaky Gut
por: d’Angelo, Michele, et al.
Publicado: (2023)

Taurine and oxidative stress in retinal health and disease
por: Castelli, Vanessa, et al.
Publicado: (2021)

CXCR1/2 pathways in paclitaxel-induced neuropathic pain
por: Laura, Brandolini, et al.
Publicado: (2017)

Looking for In Vitro Models for Retinal Diseases
por: Alfonsetti, Margherita, et al.
Publicado: (2021)

Ladarixin, an inhibitor of the interleukin‐8 receptors CXCR1 and CXCR2, in new‐onset type 1 diabetes: A multicentre, randomized, double‐blind, placebo‐controlled trial
por: Piemonti, Lorenzo, et al.
Publicado: (2022)

S-Carboxymethyl Cysteine Protects against Oxidative Stress and Mitochondrial Impairment in a Parkinson’s Disease In Vitro Model
por: Catanesi, Mariano, et al.
Publicado: (2021)

L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson’s Disease
por: Catanesi, Mariano, et al.
Publicado: (2021)

Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment
por: Kemp, Daria Marley, et al.
Publicado: (2017)

Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain
por: Brandolini, Laura, et al.
Publicado: (2019)

Inflammation-Independent Antinociceptive Effects of DF2755A, a CXCR1/2 Selective Inhibitor: A New Potential Therapeutic Treatment for Peripheral Neuropathy Associated to Non-Ulcerative Interstitial Cystitis/Bladder Pain Syndrome
por: Brandolini, Laura, et al.
Publicado: (2022)

NSAIDs-dependent adaption of the mitochondria-proteasome system in immortalized human cardiomyocytes
por: Brandolini, Laura, et al.
Publicado: (2020)

Emerging Role of C5 Complement Pathway in Peripheral Neuropathies: Current Treatments and Future Perspectives
por: Giorgio, Cristina, et al.
Publicado: (2021)

Autocrine CXCL8-dependent invasiveness triggers modulation of actin cytoskeletal network and cell dynamics
por: Antonosante, Andrea, et al.
Publicado: (2020)

Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling
por: Brandolini, Laura, et al.
Publicado: (2015)

Intranasal delivery of NGF rescues hearing impairment in aged SAMP8 mice
por: Castelli, Vanessa, et al.
Publicado: (2023)

PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress
por: Castelli, Vanessa, et al.
Publicado: (2021)

Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson’s disease models
por: Antonosante, Andrea, et al.
Publicado: (2023)

The CXCR1/CXCR2 Inhibitor Reparixin Alters the Development of Myelofibrosis in the Gata1 (low) Mice
por: Verachi, Paola, et al.
Publicado: (2022)

Intravitreal Administration of rhNGF Enhances Regenerative Processes in a Zebrafish Model of Retinal Degeneration
por: Cocchiaro, Pasquale, et al.
Publicado: (2022)

Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models
por: Castelli, Vanessa, et al.
Publicado: (2020)

Phospholipid Derivatives of Cinnamic Acid Restore Insulin Sensitivity in Insulin Resistance in 3T3-L1 Adipocytes
por: Małodobra-Mazur, Małgorzata, et al.
Publicado: (2021)

Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease
por: Alfonsetti, Margherita, et al.
Publicado: (2022)

Neurotrophic factor-based pharmacological approaches in neurological disorders
por: Alfonsetti, Margherita, et al.
Publicado: (2022)

Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions
por: Brandolini, Laura, et al.
Publicado: (2022)

DF2726A, a new IL-8 signalling inhibitor, is able to counteract chemotherapy-induced neuropathic pain
por: Brandolini, Laura, et al.
Publicado: (2019)

Proteomic Analysis of 3T3-L1 Adipocytes Treated with Insulin and TNF-α
por: Chan, Hayley, et al.
Publicado: (2019)

High-dose Resveratrol Inhibits Insulin Signaling Pathway in 3T3-L1 Adipocytes
por: Lee, Haemi, et al.
Publicado: (2013)

Bidirectional modulation of insulin action by reactive oxygen species in 3T3-L1 adipocytes
por: Ma, Mingfeng, et al.
Publicado: (2018)

Oncostatin M Induces Lipolysis and Suppresses Insulin Response in 3T3-L1 Adipocytes
por: Bailey, Jennifer L., et al.
Publicado: (2022)

4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression
por: Gao, Feng, et al.
Publicado: (2015)

A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes
por: Qin, Ji-Huan, et al.
Publicado: (2015)

Proinflammatory cytokine production and insulin sensitivity regulated by overexpression of resistin in 3T3-L1 adipocytes
por: Fu, Yuchang, et al.
Publicado: (2006)

Stevioside from Stevia rebaudiana Bertoni Increases Insulin Sensitivity in 3T3-L1 Adipocytes
por: Mohd-Radzman, Nabilatul Hani, et al.
Publicado: (2013)

Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes
por: Zhang, Ruixin, et al.
Publicado: (2018)

Antidiabetic activities of Bolanthus spergulifolius (Caryophyllaceae) extracts on insulin-resistant 3T3-L1 adipocytes
por: Derici, Gizem Ece, et al.
Publicado: (2021)

DNMT3a and TET2 in adipocyte insulin sensitivity
por: Villivalam, Sneha Damal, et al.
Publicado: (2018)

Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes
por: Lee, Hyejin, et al.
Publicado: (2016)

Inhibition of the Monocarboxylate Transporter 1 (MCT1) Promotes 3T3-L1 Adipocyte Proliferation and Enhances Insulin Sensitivity
por: Bailey, Tracey, et al.
Publicado: (2022)

CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet
por: Kurita, Kenichi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_mbdru4cnd6ede6h1a5mmbsk5bk