Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesi...

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Detalles Bibliográficos
Autores principales: Chen, Rongxiang, Xu, Shaohong, Shen, Fumin, Xu, Canran, Wang, Kaikai, Wang, Zhanyong, Liu, Lantao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471771/
https://www.ncbi.nlm.nih.gov/pubmed/34577023
http://dx.doi.org/10.3390/molecules26185551
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author Chen, Rongxiang
Xu, Shaohong
Shen, Fumin
Xu, Canran
Wang, Kaikai
Wang, Zhanyong
Liu, Lantao
author_facet Chen, Rongxiang
Xu, Shaohong
Shen, Fumin
Xu, Canran
Wang, Kaikai
Wang, Zhanyong
Liu, Lantao
author_sort Chen, Rongxiang
collection PubMed
description A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.
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spelling pubmed-84717712021-09-28 Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides Chen, Rongxiang Xu, Shaohong Shen, Fumin Xu, Canran Wang, Kaikai Wang, Zhanyong Liu, Lantao Molecules Article A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields. MDPI 2021-09-13 /pmc/articles/PMC8471771/ /pubmed/34577023 http://dx.doi.org/10.3390/molecules26185551 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Rongxiang
Xu, Shaohong
Shen, Fumin
Xu, Canran
Wang, Kaikai
Wang, Zhanyong
Liu, Lantao
Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides
title Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides
title_full Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides
title_fullStr Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides
title_full_unstemmed Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides
title_short Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides
title_sort facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471771/
https://www.ncbi.nlm.nih.gov/pubmed/34577023
http://dx.doi.org/10.3390/molecules26185551
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