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The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin

Canine degenerative myelopathy (DM), recognized as a spontaneous model of amyotrophic lateral sclerosis, is known as a late-onset progressive degenerative disease of the spinal cord. Because of the progressive nature of DM, many dogs are elected to be euthanized, resulting in limited information on...

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Autores principales: Kobatake, Yui, Nakata, Kohei, Sakai, Hiroki, Sasaki, Jun, Yamato, Osamu, Takashima, Satoshi, Nishii, Naohito, Maeda, Sadatoshi, Islam, Md Shafiqul, Kamishina, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471773/
https://www.ncbi.nlm.nih.gov/pubmed/34564586
http://dx.doi.org/10.3390/vetsci8090192
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author Kobatake, Yui
Nakata, Kohei
Sakai, Hiroki
Sasaki, Jun
Yamato, Osamu
Takashima, Satoshi
Nishii, Naohito
Maeda, Sadatoshi
Islam, Md Shafiqul
Kamishina, Hiroaki
author_facet Kobatake, Yui
Nakata, Kohei
Sakai, Hiroki
Sasaki, Jun
Yamato, Osamu
Takashima, Satoshi
Nishii, Naohito
Maeda, Sadatoshi
Islam, Md Shafiqul
Kamishina, Hiroaki
author_sort Kobatake, Yui
collection PubMed
description Canine degenerative myelopathy (DM), recognized as a spontaneous model of amyotrophic lateral sclerosis, is known as a late-onset progressive degenerative disease of the spinal cord. Because of the progressive nature of DM, many dogs are elected to be euthanized, resulting in limited information on the end-stage clinical presentation. We investigated the long-term clinical course from diagnosis to natural death to further deepen our understanding of the entire clinical picture of this disease. Because curcumin was administered in some cases, the therapeutic effect of curcumin on DM was also examined. Forty dogs included in this study were client-owned Pembroke Welsh Corgis with a definitive diagnosis of DM by necropsy and histopathology. Dogs were excluded from this study if they died from another disease or were elected to be euthanized. Information on the long-term clinical symptoms of DM was investigated based on a questionnaire, which was collected from the dog owners. Urinary incontinence and respiratory disorder were observed in most dogs, as was respiratory impairment-correlated death. In contrast, signs consistent with brainstem dysfunction were noticed at the terminal stage in a small portion of dogs. Although further studies with more cases are needed, the results of this study suggest that administration of curcumin is effective in slowing the progression of DM.
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spelling pubmed-84717732021-09-28 The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin Kobatake, Yui Nakata, Kohei Sakai, Hiroki Sasaki, Jun Yamato, Osamu Takashima, Satoshi Nishii, Naohito Maeda, Sadatoshi Islam, Md Shafiqul Kamishina, Hiroaki Vet Sci Communication Canine degenerative myelopathy (DM), recognized as a spontaneous model of amyotrophic lateral sclerosis, is known as a late-onset progressive degenerative disease of the spinal cord. Because of the progressive nature of DM, many dogs are elected to be euthanized, resulting in limited information on the end-stage clinical presentation. We investigated the long-term clinical course from diagnosis to natural death to further deepen our understanding of the entire clinical picture of this disease. Because curcumin was administered in some cases, the therapeutic effect of curcumin on DM was also examined. Forty dogs included in this study were client-owned Pembroke Welsh Corgis with a definitive diagnosis of DM by necropsy and histopathology. Dogs were excluded from this study if they died from another disease or were elected to be euthanized. Information on the long-term clinical symptoms of DM was investigated based on a questionnaire, which was collected from the dog owners. Urinary incontinence and respiratory disorder were observed in most dogs, as was respiratory impairment-correlated death. In contrast, signs consistent with brainstem dysfunction were noticed at the terminal stage in a small portion of dogs. Although further studies with more cases are needed, the results of this study suggest that administration of curcumin is effective in slowing the progression of DM. MDPI 2021-09-12 /pmc/articles/PMC8471773/ /pubmed/34564586 http://dx.doi.org/10.3390/vetsci8090192 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kobatake, Yui
Nakata, Kohei
Sakai, Hiroki
Sasaki, Jun
Yamato, Osamu
Takashima, Satoshi
Nishii, Naohito
Maeda, Sadatoshi
Islam, Md Shafiqul
Kamishina, Hiroaki
The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin
title The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin
title_full The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin
title_fullStr The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin
title_full_unstemmed The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin
title_short The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin
title_sort long-term clinical course of canine degenerative myelopathy and therapeutic potential of curcumin
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471773/
https://www.ncbi.nlm.nih.gov/pubmed/34564586
http://dx.doi.org/10.3390/vetsci8090192
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