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Ferroptosis Meets Cell–Cell Contacts
Ferroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471828/ https://www.ncbi.nlm.nih.gov/pubmed/34572111 http://dx.doi.org/10.3390/cells10092462 |
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author | Dietrich, Cornelia Hofmann, Thomas G. |
author_facet | Dietrich, Cornelia Hofmann, Thomas G. |
author_sort | Dietrich, Cornelia |
collection | PubMed |
description | Ferroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues. Deregulated ferroptosis has been linked to human diseases, such as neurodegenerative diseases, cardiovascular disorders, and cancer. Along these lines, ferroptosis is a promising pathway to overcoming therapy resistance of cancer cells. It is therefore of utmost importance to understand the cellular signalling pathways and the molecular mechanisms underlying ferroptosis regulation, including context-specific effects mediated by the neighbouring cells through cell–cell contacts. Here, we give an overview on the molecular events and machinery linked to ferroptosis induction and commitment. We further summarize and discuss current knowledge about the role of cell–cell contacts, which differ in ferroptosis regulation between normal somatic cells and cancer cells. We present emerging concepts on the underlying mechanisms, address open questions, and discuss the possible impact of cell–cell contacts on exploiting ferroptosis in cancer therapy. |
format | Online Article Text |
id | pubmed-8471828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84718282021-09-28 Ferroptosis Meets Cell–Cell Contacts Dietrich, Cornelia Hofmann, Thomas G. Cells Review Ferroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues. Deregulated ferroptosis has been linked to human diseases, such as neurodegenerative diseases, cardiovascular disorders, and cancer. Along these lines, ferroptosis is a promising pathway to overcoming therapy resistance of cancer cells. It is therefore of utmost importance to understand the cellular signalling pathways and the molecular mechanisms underlying ferroptosis regulation, including context-specific effects mediated by the neighbouring cells through cell–cell contacts. Here, we give an overview on the molecular events and machinery linked to ferroptosis induction and commitment. We further summarize and discuss current knowledge about the role of cell–cell contacts, which differ in ferroptosis regulation between normal somatic cells and cancer cells. We present emerging concepts on the underlying mechanisms, address open questions, and discuss the possible impact of cell–cell contacts on exploiting ferroptosis in cancer therapy. MDPI 2021-09-17 /pmc/articles/PMC8471828/ /pubmed/34572111 http://dx.doi.org/10.3390/cells10092462 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dietrich, Cornelia Hofmann, Thomas G. Ferroptosis Meets Cell–Cell Contacts |
title | Ferroptosis Meets Cell–Cell Contacts |
title_full | Ferroptosis Meets Cell–Cell Contacts |
title_fullStr | Ferroptosis Meets Cell–Cell Contacts |
title_full_unstemmed | Ferroptosis Meets Cell–Cell Contacts |
title_short | Ferroptosis Meets Cell–Cell Contacts |
title_sort | ferroptosis meets cell–cell contacts |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471828/ https://www.ncbi.nlm.nih.gov/pubmed/34572111 http://dx.doi.org/10.3390/cells10092462 |
work_keys_str_mv | AT dietrichcornelia ferroptosismeetscellcellcontacts AT hofmannthomasg ferroptosismeetscellcellcontacts |