Cargando…

Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

The successful development of effective treatments against nonalcoholic steatohepatitis (NASH) is significantly set back by the limited availability of predictive preclinical models, thereby delaying and reducing patient recovery. Uniquely, the guinea pig NASH model develops hepatic histopathology a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Skat-Rørdam, Josephine, Ipsen, David H., Seemann, Stefan E., Latta, Markus, Lykkesfeldt, Jens, Tveden-Nyborg, Pernille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471870/ https://www.ncbi.nlm.nih.gov/pubmed/34572384 http://dx.doi.org/10.3390/biomedicines9091198

Ejemplares similares

Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in Guinea Pigs with Non-Alcoholic Steatohepatitis
por: Pedersen, Kamilla, et al.
Publicado: (2023)

Differential Effects of Dietary Components on Glucose Intolerance and Non-Alcoholic Steatohepatitis
por: Skat-Rørdam, Josephine, et al.
Publicado: (2021)

Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig
por: Skat-Rørdam, Josephine, et al.
Publicado: (2021)

The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs
por: Ipsen, D. H., et al.
Publicado: (2021)

A role of peroxisome proliferator‐activated receptor γ in non‐alcoholic fatty liver disease
por: Skat‐Rørdam, Josephine, et al.
Publicado: (2019)

Atorvastatin and Vitamin E Accelerates NASH Resolution by Dietary Intervention in a Preclinical Guinea Pig Model
por: Klaebel, Julie Hviid, et al.
Publicado: (2019)

Vitamin C Deficiency Exacerbates Dysfunction of Atherosclerotic Coronary Arteries in Guinea Pigs Fed a High-Fat Diet
por: Skovsted, Gry Freja, et al.
Publicado: (2022)

High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs
por: Ipsen, David Højland, et al.
Publicado: (2016)

l-dehydroascorbic acid can substitute l-ascorbic acid as dietary vitamin C source in guinea pigs
por: Frikke-Schmidt, Henriette, et al.
Publicado: (2015)

Does Vitamin C Deficiency Promote Fatty Liver Disease Development?
por: Ipsen, David Højland, et al.
Publicado: (2014)

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
por: Ipsen, David Højland, et al.
Publicado: (2018)

Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains
por: Paidi, Maya D., et al.
Publicado: (2014)

Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model
por: Hansen, Stine N., et al.
Publicado: (2018)

Vitamin C Deficiency Reduces Muscarinic Receptor Coronary Artery Vasoconstriction and Plasma Tetrahydrobiopterin Concentration in Guinea Pigs
por: Skovsted, Gry Freja, et al.
Publicado: (2017)

Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs
por: Tveden-Nyborg, Pernille, et al.
Publicado: (2012)

The Pharmacokinetics of Vitamin C
por: Lykkesfeldt, Jens, et al.
Publicado: (2019)

Regulation of Vitamin C Homeostasis during Deficiency
por: Lindblad, Maiken, et al.
Publicado: (2013)

Does Vitamin C Deficiency Affect Cognitive Development and Function?
por: Hansen, Stine Normann, et al.
Publicado: (2014)

Extracellular Vesicles as Drivers of Non-Alcoholic Fatty Liver Disease: Small Particles with Big Impact
por: Ipsen, David Højland, et al.
Publicado: (2021)

Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?
por: Zisser, Alexandra, et al.
Publicado: (2021)

Chronic Vitamin C Deficiency Promotes Redox Imbalance in the Brain but Does Not Alter Sodium-Dependent Vitamin C Transporter 2 Expression
por: Paidi, Maya D., et al.
Publicado: (2014)

Vitamin C Deficiency in the Young Brain—Findings from Experimental Animal Models †
por: Tveden-Nyborg, Pernille
Publicado: (2021)

Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation
por: Klaebel, Julie Hviid, et al.
Publicado: (2020)

Spatial Memory Dysfunction Induced by Vitamin C Deficiency Is Associated with Changes in Monoaminergic Neurotransmitters and Aberrant Synapse Formation
por: Hansen, Stine Normann, et al.
Publicado: (2018)

A Long-Term Energy-Rich Diet Increases Prefrontal BDNF in Sprague-Dawley Rats
por: Virtuoso, Alessandro, et al.
Publicado: (2021)

Alcoholic, Nonalcoholic, and Toxicant-Associated Steatohepatitis: Mechanistic Similarities and Differences
por: Joshi-Barve, Swati, et al.
Publicado: (2015)

Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
por: Imajo, Kento, et al.
Publicado: (2013)

Nonalcoholic Steatohepatitis: A Search for Factual Animal Models
por: Sanches, Sheila Cristina L., et al.
Publicado: (2015)

Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis
por: Ninomiya, Masashi, et al.
Publicado: (2012)

Correction: Medaka as a model for human nonalcoholic steatohepatitis
por: Matsumoto, Toshihiko, et al.
Publicado: (2023)

Necroptosis in Nonalcoholic Steatohepatitis
por: Gautheron, Jérémie, et al.
Publicado: (2015)

Modelling severe Staphylococcus aureus sepsis in conscious pigs: are implications for animal welfare justified?
por: Olsen, Helle G., et al.
Publicado: (2016)

Transmission in the Guinea Pig Model
por: Lowen, Anice C., et al.
Publicado: (2014)

Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet
por: Bahcecioglu, Ibrahim Halil, et al.
Publicado: (2010)

A 3D Human Liver Model of Nonalcoholic Steatohepatitis
por: Duriez, Marion, et al.
Publicado: (2020)

Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders
por: Frederiksen, Henriette Reventlow, et al.
Publicado: (2021)

Establishment and Comparison of Juvenile Female Mouse Models of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
por: Zhou, Lishan, et al.
Publicado: (2018)

Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
por: Lee, Chanbin, et al.
Publicado: (2019)

Apoptosis and diagnosis of nonalcoholic steatohepatitis
por: Kim, Chang Wook, et al.
Publicado: (2011)

Antioxidant Therapy in Nonalcoholic Steatohepatitis
por: Al-Busafi, Said A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8mvf8iv3q09ijv33g03mcbcg0u