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Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study
Although body mass index (BMI) is a potential risk factor for bronchiectasis in young adults, the association between BMI and incident bronchiectasis has not been well elucidated. This study included 6,329,838 individuals aged 20–40 years from the Korean National Health Insurance Service database 20...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471914/ https://www.ncbi.nlm.nih.gov/pubmed/34579084 http://dx.doi.org/10.3390/nu13093206 |
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author | Yang, Bumhee Han, Kyungdo Kim, Sang Hyuk Lee, Dong-Hwa Park, Sang Hyun Yoo, Jung Eun Shin, Dong Wook Choi, Hayoung Lee, Hyun |
author_facet | Yang, Bumhee Han, Kyungdo Kim, Sang Hyuk Lee, Dong-Hwa Park, Sang Hyun Yoo, Jung Eun Shin, Dong Wook Choi, Hayoung Lee, Hyun |
author_sort | Yang, Bumhee |
collection | PubMed |
description | Although body mass index (BMI) is a potential risk factor for bronchiectasis in young adults, the association between BMI and incident bronchiectasis has not been well elucidated. This study included 6,329,838 individuals aged 20–40 years from the Korean National Health Insurance Service database 2009–2012 who were followed up until the date of the diagnosis of bronchiectasis, death, or 31 December 2018. We evaluated the incidence and risk of bronchiectasis according to the BMI category. The incidence rate of bronchiectasis increased as BMI decreased in a dose-dependent manner (p for trend <0.01). In multivariable Cox regression analysis, being underweight was an independent risk factor for the development of bronchiectasis, with a hazard ratio of 1.24 (95% confidence interval, 1.19–1.30) compared to being normal weight. In subgroup analysis, the effect of being underweight on the development of bronchiectasis was more evident in males and older individuals (30–40 years) than females and younger individuals (20–29 years), respectively (p for interaction <0.01 for both). These results remained significant in subgroup analysis in which subjects with comorbidities related to being underweight were excluded. Being underweight may be a novel risk factor for the development of bronchiectasis in young adults. |
format | Online Article Text |
id | pubmed-8471914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84719142021-09-28 Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study Yang, Bumhee Han, Kyungdo Kim, Sang Hyuk Lee, Dong-Hwa Park, Sang Hyun Yoo, Jung Eun Shin, Dong Wook Choi, Hayoung Lee, Hyun Nutrients Article Although body mass index (BMI) is a potential risk factor for bronchiectasis in young adults, the association between BMI and incident bronchiectasis has not been well elucidated. This study included 6,329,838 individuals aged 20–40 years from the Korean National Health Insurance Service database 2009–2012 who were followed up until the date of the diagnosis of bronchiectasis, death, or 31 December 2018. We evaluated the incidence and risk of bronchiectasis according to the BMI category. The incidence rate of bronchiectasis increased as BMI decreased in a dose-dependent manner (p for trend <0.01). In multivariable Cox regression analysis, being underweight was an independent risk factor for the development of bronchiectasis, with a hazard ratio of 1.24 (95% confidence interval, 1.19–1.30) compared to being normal weight. In subgroup analysis, the effect of being underweight on the development of bronchiectasis was more evident in males and older individuals (30–40 years) than females and younger individuals (20–29 years), respectively (p for interaction <0.01 for both). These results remained significant in subgroup analysis in which subjects with comorbidities related to being underweight were excluded. Being underweight may be a novel risk factor for the development of bronchiectasis in young adults. MDPI 2021-09-15 /pmc/articles/PMC8471914/ /pubmed/34579084 http://dx.doi.org/10.3390/nu13093206 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yang, Bumhee Han, Kyungdo Kim, Sang Hyuk Lee, Dong-Hwa Park, Sang Hyun Yoo, Jung Eun Shin, Dong Wook Choi, Hayoung Lee, Hyun Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study |
title | Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study |
title_full | Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study |
title_fullStr | Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study |
title_full_unstemmed | Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study |
title_short | Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study |
title_sort | being underweight increases the risk of non-cystic fibrosis bronchiectasis in the young population: a nationwide population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471914/ https://www.ncbi.nlm.nih.gov/pubmed/34579084 http://dx.doi.org/10.3390/nu13093206 |
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