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Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD

SIMPLE SUMMARY: The present study reveals that the FDA-approved drug idebenone has therapeutic effects on the pathology of Alzheimer’s disease (AD) in a mouse model. In particular, idebenone regulates pathological progression associated with Aβ by downregulating the non-amyloidogenic pathway, inhibi...

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Detalles Bibliográficos
Autores principales:	Lee, Hyun-ju, Jeong, Ha-Ram, Park, Jin-Hee, Hoe, Hyang-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471964/ https://www.ncbi.nlm.nih.gov/pubmed/34571815 http://dx.doi.org/10.3390/biology10090938

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