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Development and Validation of an HPLC Method for Analysis of Topotecan in Human Cerebrospinal Fluid and Its Application in Elimination Evaluation of Topotecan after Intraventricular Injection

SIMPLE SUMMARY: Intrathecal administration of anticancer drugs is an effective strategy to treat meningeal leukemia and lymphoma. Topotecan is an anticancer drug, and its anticancer effect is expected via intrathecal administration. In this study, we developed a method to measure the concentration o...

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Detalles Bibliográficos
Autores principales:	Yoshikawa, Naoki, Yamada, Ai, Yokota, Tsubasa, Yamada, Yusei, Kinoshita, Mariko, Moritake, Hiroshi, Ikeda, Ryuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471976/ https://www.ncbi.nlm.nih.gov/pubmed/34572867 http://dx.doi.org/10.3390/cancers13184643

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