Cargando…
Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women
Adult women are more likely to be obese than men. Moreover, there is evidence that obesity is a risk factor for increased insulin resistance (IR) and hypovitaminosis D (VITD), conditions related to metabolic and endocrinologic disturbance. We performed a cross-sectional study with 103 women diagnose...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471993/ https://www.ncbi.nlm.nih.gov/pubmed/34578857 http://dx.doi.org/10.3390/nu13092979 |
_version_ | 1784574613581201408 |
---|---|
author | Schleu, Minna F. Barreto-Duarte, Beatriz Arriaga, Maria B. Araujo-Pereira, Mariana Ladeia, Ana Marice Andrade, Bruno B. Lima, Maria L. |
author_facet | Schleu, Minna F. Barreto-Duarte, Beatriz Arriaga, Maria B. Araujo-Pereira, Mariana Ladeia, Ana Marice Andrade, Bruno B. Lima, Maria L. |
author_sort | Schleu, Minna F. |
collection | PubMed |
description | Adult women are more likely to be obese than men. Moreover, there is evidence that obesity is a risk factor for increased insulin resistance (IR) and hypovitaminosis D (VITD), conditions related to metabolic and endocrinologic disturbance. We performed a cross-sectional study with 103 women diagnosed with obesity, recruited between 2009 and 2013, in an obesity referral outpatient clinic in Bahia, Brazil. Laboratory and clinical characteristics were compared between the groups according to the degree of obesity (I, II and III), and levels of 25-hydroxyvitamin D [25(OH)D] were used to define the VITD status (insufficiency and no insufficiency). We calculated the homeostatic model assessment-IR (HOMA-IR) index to assess insulin resistance in the groups. Our analyses revealed that HOMA-IR values and VITD levels were inversely correlated. Furthermore, we observed a distinct expression profile of values of laboratory markers according to 25(OH)D levels. Negative correlations were found between HOMA-IR and body mass index (BMI) in VITD insufficient participants but not in those with the sufficiency. Furthermore, multivariate regression demonstrated independent associations between lower levels of 25(OH)D and increased values of HOMA-IR. These findings suggests that lower levels of VITD are strongly associated with the increased IR in obese women. |
format | Online Article Text |
id | pubmed-8471993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84719932021-09-28 Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women Schleu, Minna F. Barreto-Duarte, Beatriz Arriaga, Maria B. Araujo-Pereira, Mariana Ladeia, Ana Marice Andrade, Bruno B. Lima, Maria L. Nutrients Article Adult women are more likely to be obese than men. Moreover, there is evidence that obesity is a risk factor for increased insulin resistance (IR) and hypovitaminosis D (VITD), conditions related to metabolic and endocrinologic disturbance. We performed a cross-sectional study with 103 women diagnosed with obesity, recruited between 2009 and 2013, in an obesity referral outpatient clinic in Bahia, Brazil. Laboratory and clinical characteristics were compared between the groups according to the degree of obesity (I, II and III), and levels of 25-hydroxyvitamin D [25(OH)D] were used to define the VITD status (insufficiency and no insufficiency). We calculated the homeostatic model assessment-IR (HOMA-IR) index to assess insulin resistance in the groups. Our analyses revealed that HOMA-IR values and VITD levels were inversely correlated. Furthermore, we observed a distinct expression profile of values of laboratory markers according to 25(OH)D levels. Negative correlations were found between HOMA-IR and body mass index (BMI) in VITD insufficient participants but not in those with the sufficiency. Furthermore, multivariate regression demonstrated independent associations between lower levels of 25(OH)D and increased values of HOMA-IR. These findings suggests that lower levels of VITD are strongly associated with the increased IR in obese women. MDPI 2021-08-27 /pmc/articles/PMC8471993/ /pubmed/34578857 http://dx.doi.org/10.3390/nu13092979 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schleu, Minna F. Barreto-Duarte, Beatriz Arriaga, Maria B. Araujo-Pereira, Mariana Ladeia, Ana Marice Andrade, Bruno B. Lima, Maria L. Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women |
title | Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women |
title_full | Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women |
title_fullStr | Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women |
title_full_unstemmed | Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women |
title_short | Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women |
title_sort | lower levels of vitamin d are associated with an increase in insulin resistance in obese brazilian women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471993/ https://www.ncbi.nlm.nih.gov/pubmed/34578857 http://dx.doi.org/10.3390/nu13092979 |
work_keys_str_mv | AT schleuminnaf lowerlevelsofvitamindareassociatedwithanincreaseininsulinresistanceinobesebrazilianwomen AT barretoduartebeatriz lowerlevelsofvitamindareassociatedwithanincreaseininsulinresistanceinobesebrazilianwomen AT arriagamariab lowerlevelsofvitamindareassociatedwithanincreaseininsulinresistanceinobesebrazilianwomen AT araujopereiramariana lowerlevelsofvitamindareassociatedwithanincreaseininsulinresistanceinobesebrazilianwomen AT ladeiaanamarice lowerlevelsofvitamindareassociatedwithanincreaseininsulinresistanceinobesebrazilianwomen AT andradebrunob lowerlevelsofvitamindareassociatedwithanincreaseininsulinresistanceinobesebrazilianwomen AT limamarial lowerlevelsofvitamindareassociatedwithanincreaseininsulinresistanceinobesebrazilianwomen |