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Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women

Adult women are more likely to be obese than men. Moreover, there is evidence that obesity is a risk factor for increased insulin resistance (IR) and hypovitaminosis D (VITD), conditions related to metabolic and endocrinologic disturbance. We performed a cross-sectional study with 103 women diagnose...

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Autores principales: Schleu, Minna F., Barreto-Duarte, Beatriz, Arriaga, Maria B., Araujo-Pereira, Mariana, Ladeia, Ana Marice, Andrade, Bruno B., Lima, Maria L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471993/
https://www.ncbi.nlm.nih.gov/pubmed/34578857
http://dx.doi.org/10.3390/nu13092979
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author Schleu, Minna F.
Barreto-Duarte, Beatriz
Arriaga, Maria B.
Araujo-Pereira, Mariana
Ladeia, Ana Marice
Andrade, Bruno B.
Lima, Maria L.
author_facet Schleu, Minna F.
Barreto-Duarte, Beatriz
Arriaga, Maria B.
Araujo-Pereira, Mariana
Ladeia, Ana Marice
Andrade, Bruno B.
Lima, Maria L.
author_sort Schleu, Minna F.
collection PubMed
description Adult women are more likely to be obese than men. Moreover, there is evidence that obesity is a risk factor for increased insulin resistance (IR) and hypovitaminosis D (VITD), conditions related to metabolic and endocrinologic disturbance. We performed a cross-sectional study with 103 women diagnosed with obesity, recruited between 2009 and 2013, in an obesity referral outpatient clinic in Bahia, Brazil. Laboratory and clinical characteristics were compared between the groups according to the degree of obesity (I, II and III), and levels of 25-hydroxyvitamin D [25(OH)D] were used to define the VITD status (insufficiency and no insufficiency). We calculated the homeostatic model assessment-IR (HOMA-IR) index to assess insulin resistance in the groups. Our analyses revealed that HOMA-IR values and VITD levels were inversely correlated. Furthermore, we observed a distinct expression profile of values of laboratory markers according to 25(OH)D levels. Negative correlations were found between HOMA-IR and body mass index (BMI) in VITD insufficient participants but not in those with the sufficiency. Furthermore, multivariate regression demonstrated independent associations between lower levels of 25(OH)D and increased values of HOMA-IR. These findings suggests that lower levels of VITD are strongly associated with the increased IR in obese women.
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spelling pubmed-84719932021-09-28 Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women Schleu, Minna F. Barreto-Duarte, Beatriz Arriaga, Maria B. Araujo-Pereira, Mariana Ladeia, Ana Marice Andrade, Bruno B. Lima, Maria L. Nutrients Article Adult women are more likely to be obese than men. Moreover, there is evidence that obesity is a risk factor for increased insulin resistance (IR) and hypovitaminosis D (VITD), conditions related to metabolic and endocrinologic disturbance. We performed a cross-sectional study with 103 women diagnosed with obesity, recruited between 2009 and 2013, in an obesity referral outpatient clinic in Bahia, Brazil. Laboratory and clinical characteristics were compared between the groups according to the degree of obesity (I, II and III), and levels of 25-hydroxyvitamin D [25(OH)D] were used to define the VITD status (insufficiency and no insufficiency). We calculated the homeostatic model assessment-IR (HOMA-IR) index to assess insulin resistance in the groups. Our analyses revealed that HOMA-IR values and VITD levels were inversely correlated. Furthermore, we observed a distinct expression profile of values of laboratory markers according to 25(OH)D levels. Negative correlations were found between HOMA-IR and body mass index (BMI) in VITD insufficient participants but not in those with the sufficiency. Furthermore, multivariate regression demonstrated independent associations between lower levels of 25(OH)D and increased values of HOMA-IR. These findings suggests that lower levels of VITD are strongly associated with the increased IR in obese women. MDPI 2021-08-27 /pmc/articles/PMC8471993/ /pubmed/34578857 http://dx.doi.org/10.3390/nu13092979 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schleu, Minna F.
Barreto-Duarte, Beatriz
Arriaga, Maria B.
Araujo-Pereira, Mariana
Ladeia, Ana Marice
Andrade, Bruno B.
Lima, Maria L.
Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women
title Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women
title_full Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women
title_fullStr Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women
title_full_unstemmed Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women
title_short Lower Levels of Vitamin D Are Associated with an Increase in Insulin Resistance in Obese Brazilian Women
title_sort lower levels of vitamin d are associated with an increase in insulin resistance in obese brazilian women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471993/
https://www.ncbi.nlm.nih.gov/pubmed/34578857
http://dx.doi.org/10.3390/nu13092979
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