Cargando…
Extrusion-Based 3D Printing of Calcium Magnesium Phosphate Cement Pastes for Degradable Bone Implants
This study aimed to develop printable calcium magnesium phosphate pastes that harden by immersion in ammonium phosphate solution post-printing. Besides the main mineral compound, biocompatible ceramic, magnesium oxide and hydroxypropylmethylcellulose (HPMC) were the crucial components. Two pastes wi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472049/ https://www.ncbi.nlm.nih.gov/pubmed/34576421 http://dx.doi.org/10.3390/ma14185197 |
_version_ | 1784574628299014144 |
---|---|
author | Götz, Lisa-Marie Holeczek, Katharina Groll, Jürgen Jüngst, Tomasz Gbureck, Uwe |
author_facet | Götz, Lisa-Marie Holeczek, Katharina Groll, Jürgen Jüngst, Tomasz Gbureck, Uwe |
author_sort | Götz, Lisa-Marie |
collection | PubMed |
description | This study aimed to develop printable calcium magnesium phosphate pastes that harden by immersion in ammonium phosphate solution post-printing. Besides the main mineral compound, biocompatible ceramic, magnesium oxide and hydroxypropylmethylcellulose (HPMC) were the crucial components. Two pastes with different powder to liquid ratios of 1.35 g/mL and 1.93 g/mL were characterized regarding their rheological properties. Here, ageing over the course of 24 h showed an increase in viscosity and extrusion force, which was attributed to structural changes in HPMC as well as the formation of magnesium hydroxide by hydration of MgO. The pastes enabled printing of porous scaffolds with good dimensional stability and enabled a setting reaction to struvite when immersed in ammonium phosphate solution. Mechanical performance under compression was approx. 8–20 MPa as a monolithic structure and 1.6–3.0 MPa for printed macroporous scaffolds, depending on parameters such as powder to liquid ratio, ageing time, strand thickness and distance. |
format | Online Article Text |
id | pubmed-8472049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84720492021-09-28 Extrusion-Based 3D Printing of Calcium Magnesium Phosphate Cement Pastes for Degradable Bone Implants Götz, Lisa-Marie Holeczek, Katharina Groll, Jürgen Jüngst, Tomasz Gbureck, Uwe Materials (Basel) Article This study aimed to develop printable calcium magnesium phosphate pastes that harden by immersion in ammonium phosphate solution post-printing. Besides the main mineral compound, biocompatible ceramic, magnesium oxide and hydroxypropylmethylcellulose (HPMC) were the crucial components. Two pastes with different powder to liquid ratios of 1.35 g/mL and 1.93 g/mL were characterized regarding their rheological properties. Here, ageing over the course of 24 h showed an increase in viscosity and extrusion force, which was attributed to structural changes in HPMC as well as the formation of magnesium hydroxide by hydration of MgO. The pastes enabled printing of porous scaffolds with good dimensional stability and enabled a setting reaction to struvite when immersed in ammonium phosphate solution. Mechanical performance under compression was approx. 8–20 MPa as a monolithic structure and 1.6–3.0 MPa for printed macroporous scaffolds, depending on parameters such as powder to liquid ratio, ageing time, strand thickness and distance. MDPI 2021-09-10 /pmc/articles/PMC8472049/ /pubmed/34576421 http://dx.doi.org/10.3390/ma14185197 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Götz, Lisa-Marie Holeczek, Katharina Groll, Jürgen Jüngst, Tomasz Gbureck, Uwe Extrusion-Based 3D Printing of Calcium Magnesium Phosphate Cement Pastes for Degradable Bone Implants |
title | Extrusion-Based 3D Printing of Calcium Magnesium Phosphate Cement Pastes for Degradable Bone Implants |
title_full | Extrusion-Based 3D Printing of Calcium Magnesium Phosphate Cement Pastes for Degradable Bone Implants |
title_fullStr | Extrusion-Based 3D Printing of Calcium Magnesium Phosphate Cement Pastes for Degradable Bone Implants |
title_full_unstemmed | Extrusion-Based 3D Printing of Calcium Magnesium Phosphate Cement Pastes for Degradable Bone Implants |
title_short | Extrusion-Based 3D Printing of Calcium Magnesium Phosphate Cement Pastes for Degradable Bone Implants |
title_sort | extrusion-based 3d printing of calcium magnesium phosphate cement pastes for degradable bone implants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472049/ https://www.ncbi.nlm.nih.gov/pubmed/34576421 http://dx.doi.org/10.3390/ma14185197 |
work_keys_str_mv | AT gotzlisamarie extrusionbased3dprintingofcalciummagnesiumphosphatecementpastesfordegradableboneimplants AT holeczekkatharina extrusionbased3dprintingofcalciummagnesiumphosphatecementpastesfordegradableboneimplants AT grolljurgen extrusionbased3dprintingofcalciummagnesiumphosphatecementpastesfordegradableboneimplants AT jungsttomasz extrusionbased3dprintingofcalciummagnesiumphosphatecementpastesfordegradableboneimplants AT gbureckuwe extrusionbased3dprintingofcalciummagnesiumphosphatecementpastesfordegradableboneimplants |