Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?

Trypanosomatids are easy to cultivate and they are (in many cases) amenable to genetic manipulation. Genome sequencing has become a standard tool routinely used in the study of these flagellates. In this review, we summarize the current state of the field and our vision of what needs to be done in o...

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Autores principales: Yurchenko, Vyacheslav, Butenko, Anzhelika, Kostygov, Alexei Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472099/
https://www.ncbi.nlm.nih.gov/pubmed/34578156
http://dx.doi.org/10.3390/pathogens10091124
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author Yurchenko, Vyacheslav
Butenko, Anzhelika
Kostygov, Alexei Y.
author_facet Yurchenko, Vyacheslav
Butenko, Anzhelika
Kostygov, Alexei Y.
author_sort Yurchenko, Vyacheslav
collection PubMed
description Trypanosomatids are easy to cultivate and they are (in many cases) amenable to genetic manipulation. Genome sequencing has become a standard tool routinely used in the study of these flagellates. In this review, we summarize the current state of the field and our vision of what needs to be done in order to achieve a more comprehensive picture of trypanosomatid evolution. This will also help to illuminate the lineage-specific proteins and pathways, which can be used as potential targets in treating diseases caused by these parasites.
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spelling pubmed-84720992021-09-28 Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done? Yurchenko, Vyacheslav Butenko, Anzhelika Kostygov, Alexei Y. Pathogens Review Trypanosomatids are easy to cultivate and they are (in many cases) amenable to genetic manipulation. Genome sequencing has become a standard tool routinely used in the study of these flagellates. In this review, we summarize the current state of the field and our vision of what needs to be done in order to achieve a more comprehensive picture of trypanosomatid evolution. This will also help to illuminate the lineage-specific proteins and pathways, which can be used as potential targets in treating diseases caused by these parasites. MDPI 2021-09-02 /pmc/articles/PMC8472099/ /pubmed/34578156 http://dx.doi.org/10.3390/pathogens10091124 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yurchenko, Vyacheslav
Butenko, Anzhelika
Kostygov, Alexei Y.
Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?
title Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?
title_full Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?
title_fullStr Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?
title_full_unstemmed Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?
title_short Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?
title_sort genomics of trypanosomatidae: where we stand and what needs to be done?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472099/
https://www.ncbi.nlm.nih.gov/pubmed/34578156
http://dx.doi.org/10.3390/pathogens10091124
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