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Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis

Central and peripheral hormone deficiencies have been documented during and after acute hantavirus infection. Thrombocytopenia and coagulation abnormalities are common findings in haemorrhagic fever with renal syndrome (HFRS). The associations between coagulation and hormonal abnormalities in HFRS h...

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Autores principales: Tarvainen, Marlene, Mäkelä, Satu, Laine, Outi, Pörsti, Ilkka, Risku, Sari, Niemelä, Onni, Mustonen, Jukka, Jaatinen, Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472102/
https://www.ncbi.nlm.nih.gov/pubmed/34578397
http://dx.doi.org/10.3390/v13091818
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author Tarvainen, Marlene
Mäkelä, Satu
Laine, Outi
Pörsti, Ilkka
Risku, Sari
Niemelä, Onni
Mustonen, Jukka
Jaatinen, Pia
author_facet Tarvainen, Marlene
Mäkelä, Satu
Laine, Outi
Pörsti, Ilkka
Risku, Sari
Niemelä, Onni
Mustonen, Jukka
Jaatinen, Pia
author_sort Tarvainen, Marlene
collection PubMed
description Central and peripheral hormone deficiencies have been documented during and after acute hantavirus infection. Thrombocytopenia and coagulation abnormalities are common findings in haemorrhagic fever with renal syndrome (HFRS). The associations between coagulation and hormonal abnormalities in HFRS have not been studied yet. Forty-two patients diagnosed with Puumala virus (PUUV) infection were examined during the acute phase and on a follow-up visit approximately one month later. Hormonal defects were common during acute PUUV infection. Overt (clinical) hypogonadism was identified in 80% of the men and approximately 20% of the patients had overt hypothyroidism. At the one-month follow-up visit, six patients had central hormone deficits. Acute peripheral hormone deficits associated with a more severe acute kidney injury (AKI), longer hospital stay and more severe thrombocytopenia. Half of the patients with bleeding symptoms had also peripheral hormonal deficiencies. Patients with free thyroxine levels below the reference range had higher D-dimer level than patients with normal thyroid function, but no thromboembolic events occurred. Acute phase hormonal abnormalities associate with severe disease and altered haemostasis in PUUV infection.
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spelling pubmed-84721022021-09-28 Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis Tarvainen, Marlene Mäkelä, Satu Laine, Outi Pörsti, Ilkka Risku, Sari Niemelä, Onni Mustonen, Jukka Jaatinen, Pia Viruses Article Central and peripheral hormone deficiencies have been documented during and after acute hantavirus infection. Thrombocytopenia and coagulation abnormalities are common findings in haemorrhagic fever with renal syndrome (HFRS). The associations between coagulation and hormonal abnormalities in HFRS have not been studied yet. Forty-two patients diagnosed with Puumala virus (PUUV) infection were examined during the acute phase and on a follow-up visit approximately one month later. Hormonal defects were common during acute PUUV infection. Overt (clinical) hypogonadism was identified in 80% of the men and approximately 20% of the patients had overt hypothyroidism. At the one-month follow-up visit, six patients had central hormone deficits. Acute peripheral hormone deficits associated with a more severe acute kidney injury (AKI), longer hospital stay and more severe thrombocytopenia. Half of the patients with bleeding symptoms had also peripheral hormonal deficiencies. Patients with free thyroxine levels below the reference range had higher D-dimer level than patients with normal thyroid function, but no thromboembolic events occurred. Acute phase hormonal abnormalities associate with severe disease and altered haemostasis in PUUV infection. MDPI 2021-09-13 /pmc/articles/PMC8472102/ /pubmed/34578397 http://dx.doi.org/10.3390/v13091818 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tarvainen, Marlene
Mäkelä, Satu
Laine, Outi
Pörsti, Ilkka
Risku, Sari
Niemelä, Onni
Mustonen, Jukka
Jaatinen, Pia
Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis
title Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis
title_full Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis
title_fullStr Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis
title_full_unstemmed Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis
title_short Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis
title_sort hormonal defects are common during puumala hantavirus infection and associate with disease severity and biomarkers of altered haemostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472102/
https://www.ncbi.nlm.nih.gov/pubmed/34578397
http://dx.doi.org/10.3390/v13091818
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