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Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials

As inflammation frequently occurs after the implantation of a medical device, biocompatible, antibacterial materials must be used. Polymer–metal nanocomposites are promising materials. Here we prepared enhanced polyethylene naphthalate (PEN) using surface modification techniques and investigated its...

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Autores principales: Pryjmaková, Jana, Kaimlová, Markéta, Vokatá, Barbora, Hubáček, Tomáš, Slepička, Petr, Švorčík, Václav, Siegel, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472103/
https://www.ncbi.nlm.nih.gov/pubmed/34578601
http://dx.doi.org/10.3390/nano11092285
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author Pryjmaková, Jana
Kaimlová, Markéta
Vokatá, Barbora
Hubáček, Tomáš
Slepička, Petr
Švorčík, Václav
Siegel, Jakub
author_facet Pryjmaková, Jana
Kaimlová, Markéta
Vokatá, Barbora
Hubáček, Tomáš
Slepička, Petr
Švorčík, Václav
Siegel, Jakub
author_sort Pryjmaková, Jana
collection PubMed
description As inflammation frequently occurs after the implantation of a medical device, biocompatible, antibacterial materials must be used. Polymer–metal nanocomposites are promising materials. Here we prepared enhanced polyethylene naphthalate (PEN) using surface modification techniques and investigated its suitability for biomedical applications. The PEN was modified by a KrF laser forming periodic ripple patterns with specific surface characteristics. Next, Au/Ag nanowires were deposited onto the patterned PEN using vacuum evaporation. Atomic force microscopy confirmed that the surface morphology of the modified PEN changed accordingly with the incidence angle of the laser beam. Energy-dispersive X-ray spectroscopy showed that the distribution of the selected metals was dependent on the evaporation technique. Our bimetallic nanowires appear to be promising antibacterial agents due to the presence of antibacterial noble metals. The antibacterial effect of the prepared Au/Ag nanowires against E. coli and S. epidermidis was demonstrated using 24 h incubation with a drop plate test. Moreover, a WST-1 cytotoxicity test that was performed to determine the toxicity of the nanowires showed that the materials could be considered non-toxic. Collectively, these results suggest that prepared Au/Ag nanostructures are effective, biocompatible surface coatings for use in medical devices.
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spelling pubmed-84721032021-09-28 Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials Pryjmaková, Jana Kaimlová, Markéta Vokatá, Barbora Hubáček, Tomáš Slepička, Petr Švorčík, Václav Siegel, Jakub Nanomaterials (Basel) Article As inflammation frequently occurs after the implantation of a medical device, biocompatible, antibacterial materials must be used. Polymer–metal nanocomposites are promising materials. Here we prepared enhanced polyethylene naphthalate (PEN) using surface modification techniques and investigated its suitability for biomedical applications. The PEN was modified by a KrF laser forming periodic ripple patterns with specific surface characteristics. Next, Au/Ag nanowires were deposited onto the patterned PEN using vacuum evaporation. Atomic force microscopy confirmed that the surface morphology of the modified PEN changed accordingly with the incidence angle of the laser beam. Energy-dispersive X-ray spectroscopy showed that the distribution of the selected metals was dependent on the evaporation technique. Our bimetallic nanowires appear to be promising antibacterial agents due to the presence of antibacterial noble metals. The antibacterial effect of the prepared Au/Ag nanowires against E. coli and S. epidermidis was demonstrated using 24 h incubation with a drop plate test. Moreover, a WST-1 cytotoxicity test that was performed to determine the toxicity of the nanowires showed that the materials could be considered non-toxic. Collectively, these results suggest that prepared Au/Ag nanostructures are effective, biocompatible surface coatings for use in medical devices. MDPI 2021-09-02 /pmc/articles/PMC8472103/ /pubmed/34578601 http://dx.doi.org/10.3390/nano11092285 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pryjmaková, Jana
Kaimlová, Markéta
Vokatá, Barbora
Hubáček, Tomáš
Slepička, Petr
Švorčík, Václav
Siegel, Jakub
Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials
title Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials
title_full Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials
title_fullStr Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials
title_full_unstemmed Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials
title_short Bimetallic Nanowires on Laser-Patterned PEN as Promising Biomaterials
title_sort bimetallic nanowires on laser-patterned pen as promising biomaterials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472103/
https://www.ncbi.nlm.nih.gov/pubmed/34578601
http://dx.doi.org/10.3390/nano11092285
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