NRF2 in Viral Infection

The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emergi...

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Detalles Bibliográficos
Autores principales: Herengt, Angela, Thyrsted, Jacob, Holm, Christian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472116/
https://www.ncbi.nlm.nih.gov/pubmed/34573123
http://dx.doi.org/10.3390/antiox10091491
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author Herengt, Angela
Thyrsted, Jacob
Holm, Christian K.
author_facet Herengt, Angela
Thyrsted, Jacob
Holm, Christian K.
author_sort Herengt, Angela
collection PubMed
description The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emerging as an important factor in antiviral immunity through interferon-independent mechanisms. In the review, we give an overview of the scientific progress on the involvement and importance of NRF2 in the context of viral infection.
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spelling pubmed-84721162021-09-28 NRF2 in Viral Infection Herengt, Angela Thyrsted, Jacob Holm, Christian K. Antioxidants (Basel) Review The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emerging as an important factor in antiviral immunity through interferon-independent mechanisms. In the review, we give an overview of the scientific progress on the involvement and importance of NRF2 in the context of viral infection. MDPI 2021-09-18 /pmc/articles/PMC8472116/ /pubmed/34573123 http://dx.doi.org/10.3390/antiox10091491 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Herengt, Angela
Thyrsted, Jacob
Holm, Christian K.
NRF2 in Viral Infection
title NRF2 in Viral Infection
title_full NRF2 in Viral Infection
title_fullStr NRF2 in Viral Infection
title_full_unstemmed NRF2 in Viral Infection
title_short NRF2 in Viral Infection
title_sort nrf2 in viral infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472116/
https://www.ncbi.nlm.nih.gov/pubmed/34573123
http://dx.doi.org/10.3390/antiox10091491
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AT thyrstedjacob nrf2inviralinfection
AT holmchristiank nrf2inviralinfection

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