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Genomic Determinants of Homologous Recombination Deficiency across Human Cancers

SIMPLE SUMMARY: Tumors with homologous recombination deficiency (HRD) respond to Poly-ADP ribose polymerase inhibitor (PARPi) therapy in breast, ovarian, prostate, and pancreatic cancers. However, in addition to a handful of known pathogenic variants including those affecting BRCA1/2, it remains unc...

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Detalles Bibliográficos
Autores principales:	Qing, Tao, Wang, Xinfeng, Jun, Tomi, Ding, Li, Pusztai, Lajos, Huang, Kuan-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472123/ https://www.ncbi.nlm.nih.gov/pubmed/34572800 http://dx.doi.org/10.3390/cancers13184572

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