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Antiphospholipid Syndrome-Induced Leriche Syndrome in a Man with Lower Limbs Sensory and Motor Defect

Antiphospholipid syndrome (APS) is an autoimmune disorder with characteristics of arterial and/or venous thrombosis due to hypercoagulation status. Although deep vein thrombosis is common, the involvement of arterial thrombosis is more dangerous and poses a high risk of complications. Acute aorto-il...

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Autores principales: Hong, Jeng-Luen, Hou, Yueh-Tseng, Lin, Po-Chen, Chen, Yu-Long, Chien, Da-Sen, Yiang, Giou-Teng, Wu, Meng-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472144/
https://www.ncbi.nlm.nih.gov/pubmed/34564122
http://dx.doi.org/10.3390/jcdd8090104
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author Hong, Jeng-Luen
Hou, Yueh-Tseng
Lin, Po-Chen
Chen, Yu-Long
Chien, Da-Sen
Yiang, Giou-Teng
Wu, Meng-Yu
author_facet Hong, Jeng-Luen
Hou, Yueh-Tseng
Lin, Po-Chen
Chen, Yu-Long
Chien, Da-Sen
Yiang, Giou-Teng
Wu, Meng-Yu
author_sort Hong, Jeng-Luen
collection PubMed
description Antiphospholipid syndrome (APS) is an autoimmune disorder with characteristics of arterial and/or venous thrombosis due to hypercoagulation status. Although deep vein thrombosis is common, the involvement of arterial thrombosis is more dangerous and poses a high risk of complications. Acute aorto-iliac occlusive disease (AIOD, known as Leriche syndrome) is severe arterial thrombosis that is associated with high morbidity and mortality rates. Severe acute occlusion may cause spinal cord ischemia, leading to neurological defects, such as acute onset of paraplegia. Co-occurrence of acute aorto-iliac occlusive disease and antiphospholipid syndrome is rare and may present with atypical symptoms mimicking other diseases, including chronic ulcers, musculoskeletal events, and pulmonary diseases. In patients with weak femoral pulses and recurrent thrombotic events, co-occurrence of APS and AIOD should be taken into consideration. Here, we describe a rare case of co-occurrence of APS and AIOD presenting with acute lower leg weakness and numbness. Timely thrombectomies and bilateral common iliac artery stentings rescued distal blood flow. We highlight the clinical features and early diagnosis of co-occurrence of APS and AIOD in order to prevent catastrophic complications. The detailed mechanism and pathogenesis of antiphospholipid syndrome-induced acute aorto-iliac occlusive disease are also discussed.
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spelling pubmed-84721442021-09-28 Antiphospholipid Syndrome-Induced Leriche Syndrome in a Man with Lower Limbs Sensory and Motor Defect Hong, Jeng-Luen Hou, Yueh-Tseng Lin, Po-Chen Chen, Yu-Long Chien, Da-Sen Yiang, Giou-Teng Wu, Meng-Yu J Cardiovasc Dev Dis Case Report Antiphospholipid syndrome (APS) is an autoimmune disorder with characteristics of arterial and/or venous thrombosis due to hypercoagulation status. Although deep vein thrombosis is common, the involvement of arterial thrombosis is more dangerous and poses a high risk of complications. Acute aorto-iliac occlusive disease (AIOD, known as Leriche syndrome) is severe arterial thrombosis that is associated with high morbidity and mortality rates. Severe acute occlusion may cause spinal cord ischemia, leading to neurological defects, such as acute onset of paraplegia. Co-occurrence of acute aorto-iliac occlusive disease and antiphospholipid syndrome is rare and may present with atypical symptoms mimicking other diseases, including chronic ulcers, musculoskeletal events, and pulmonary diseases. In patients with weak femoral pulses and recurrent thrombotic events, co-occurrence of APS and AIOD should be taken into consideration. Here, we describe a rare case of co-occurrence of APS and AIOD presenting with acute lower leg weakness and numbness. Timely thrombectomies and bilateral common iliac artery stentings rescued distal blood flow. We highlight the clinical features and early diagnosis of co-occurrence of APS and AIOD in order to prevent catastrophic complications. The detailed mechanism and pathogenesis of antiphospholipid syndrome-induced acute aorto-iliac occlusive disease are also discussed. MDPI 2021-08-29 /pmc/articles/PMC8472144/ /pubmed/34564122 http://dx.doi.org/10.3390/jcdd8090104 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Hong, Jeng-Luen
Hou, Yueh-Tseng
Lin, Po-Chen
Chen, Yu-Long
Chien, Da-Sen
Yiang, Giou-Teng
Wu, Meng-Yu
Antiphospholipid Syndrome-Induced Leriche Syndrome in a Man with Lower Limbs Sensory and Motor Defect
title Antiphospholipid Syndrome-Induced Leriche Syndrome in a Man with Lower Limbs Sensory and Motor Defect
title_full Antiphospholipid Syndrome-Induced Leriche Syndrome in a Man with Lower Limbs Sensory and Motor Defect
title_fullStr Antiphospholipid Syndrome-Induced Leriche Syndrome in a Man with Lower Limbs Sensory and Motor Defect
title_full_unstemmed Antiphospholipid Syndrome-Induced Leriche Syndrome in a Man with Lower Limbs Sensory and Motor Defect
title_short Antiphospholipid Syndrome-Induced Leriche Syndrome in a Man with Lower Limbs Sensory and Motor Defect
title_sort antiphospholipid syndrome-induced leriche syndrome in a man with lower limbs sensory and motor defect
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472144/
https://www.ncbi.nlm.nih.gov/pubmed/34564122
http://dx.doi.org/10.3390/jcdd8090104
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