Cargando…

Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation

Blood–brain barrier (BBB) dysfunction is a key hallmark in the pathology of many neuroinflammatory disorders. Extracellular vesicles (EVs) are lipid membrane-enclosed carriers of molecular cargo that are involved in cell-to-cell communication. Circulating endothelial EVs are increased in the plasma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roig-Carles, David, Willms, Eduard, Fontijn, Ruud D., Martinez-Pacheco, Sarai, Mäger, Imre, de Vries, Helga E., Hirst, Mark, Sharrack, Basil, Male, David K., Hawkes, Cheryl A., Romero, Ignacio A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472224/ https://www.ncbi.nlm.nih.gov/pubmed/34575601 http://dx.doi.org/10.3390/pharmaceutics13091525

Ejemplares similares

MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium
por: Cerutti, Camilla, et al.
Publicado: (2017)

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression
por: Willms, Eduard, et al.
Publicado: (2018)

MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro
por: Cerutti, Camilla, et al.
Publicado: (2016)

Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues
por: Gromnicova, Radka, et al.
Publicado: (2016)

Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3
por: Lopez-Ramirez, Miguel Alejandro, et al.
Publicado: (2013)

Gold nanocarriers for transport of oligonucleotides across brain endothelial cells
por: Fatima, Nayab, et al.
Publicado: (2020)

Cerebrospinal fluid dynamics modulation by diet and cytokines in rats
por: Alimajstorovic, Zerin, et al.
Publicado: (2020)

Understanding extracellular vesicle and nanoparticle heterogeneity: Novel methods and considerations
por: Phillips, William, et al.
Publicado: (2021)

Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities
por: Osorio-Querejeta, Iñaki, et al.
Publicado: (2018)

Evidence for the Need to Evaluate More Than One Source of Extracellular Vesicles, Rather Than Single or Pooled Samples Only, When Comparing Extracellular Vesicles Separation Methods
por: Martinez-Pacheco, Sarai, et al.
Publicado: (2021)

Editorial: The Neurovascular Unit as a Potential Biomarker and Therapeutic Target in Cerebrovascular Disease
por: Nizari, Shereen, et al.
Publicado: (2022)

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA
por: de Jong, Olivier G., et al.
Publicado: (2020)

PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies
por: Silva-Abreu, Marcelle, et al.
Publicado: (2018)

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy
por: Morris, Alan W. J., et al.
Publicado: (2014)

Publisher Correction: A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA
por: de Jong, Olivier G., et al.
Publicado: (2020)

Transcriptional Control of the Multi-Drug Transporter ABCB1 by Transcription Factor Sp3 in Different Human Tissues
por: Gromnicova, Radka, et al.
Publicado: (2012)

Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer’s disease and vascular dementia
por: Chakraborty, Ananya, et al.
Publicado: (2018)

Cerebrovascular Resistance: The Basis of Cerebrovascular Reactivity
por: Duffin, James, et al.
Publicado: (2018)

Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident
por: Fringuello, Anthony, et al.
Publicado: (2021)

Cerebrovascular Disease and Statins
por: Beltrán Romero, Luis M., et al.
Publicado: (2021)

Extracellular Vesicle Profiling and Their Use as Potential Disease Specific Biomarker
por: Julich, Henrike, et al.
Publicado: (2014)

Autologous Haematopoietic Stem Cell Transplantation in Multiple Sclerosis: a Review of Current Literature and Future Directions for Transplant Haematologists and Oncologists
por: Das, Joyutpal, et al.
Publicado: (2019)

The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes
por: Pacheco, Sarai, et al.
Publicado: (2015)

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid
por: Maki, Takakuni, et al.
Publicado: (2014)

Profiling the unique protective properties of intracranial arterial endothelial cells
por: Hermkens, Dorien M. A., et al.
Publicado: (2019)

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology
por: Derada Troletti, Claudio, et al.
Publicado: (2019)

Comparison of polypeptides that bind the transferrin receptor for targeting gold nanocarriers
por: McQuaid, Conor, et al.
Publicado: (2021)

A network-based cognitive training induces cognitive improvements and neuroplastic changes in patients with relapsing-remitting multiple sclerosis: an exploratory case-control study
por: Manca, Riccardo, et al.
Publicado: (2020)

Citicoline May Prevent Cognitive Decline in Patients with Cerebrovascular Disease
por: Almeria, Marta, et al.
Publicado: (2023)

Cells release subpopulations of exosomes with distinct molecular and biological properties
por: Willms, Eduard, et al.
Publicado: (2016)

Cerebrovascular Regulation in Neurological Disorders
por: Yang, Yi, et al.
Publicado: (2018)

Single Consultation Cerebrovascular Disease Clinic
por: Thrush, David
Publicado: (2000)

Trajectories of family and employment stress associated with cerebrovascular accidents
por: Jerez, María Pilar, et al.
Publicado: (2021)

Cerebrovascular Consequences of Obstructive Sleep Apnea
por: Durgan, David J., et al.
Publicado: (2012)

New Insights into Cerebrovascular Pathophysiology and Hypertension
por: Webb, Alastair JS, et al.
Publicado: (2022)

Vascular Effects on Cerebrovascular Permeability and Neurodegeneration
por: Sulimai, Nurul, et al.
Publicado: (2023)

Multiple sclerosis in an adrenoleukodystrophy carrier
por: Jenkins, Thomas, et al.
Publicado: (2011)

Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography
por: Corso, Giulia, et al.
Publicado: (2017)

Cerebrovascular Disorders
por: Granata, Alessandra, et al.
Publicado: (2023)

Wearable sensors can reliably quantify gait alterations associated with disability in people with progressive multiple sclerosis in a clinical setting
por: Angelini, Lorenza, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3i6omqkpklacrm656cunjhd76m