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Analysis of Phthalates and Alternative Plasticizers in Gloves by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–UV Detection: A Comparative Study

Gloves represent an essential feature for hand protection because it is a requirement in the professional framework to comply with both hand hygiene standards and the principles of good laboratory practice. Despite their wide use, there is a knowledge gap regarding their composition, including phtha...

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Autores principales: Poitou, Kelly, Rogez-Florent, Tiphaine, Lecoeur, Marie, Danel, Cécile, Regnault, Romain, Vérité, Philippe, Monteil, Christelle, Foulon, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472278/
https://www.ncbi.nlm.nih.gov/pubmed/34564351
http://dx.doi.org/10.3390/toxics9090200
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author Poitou, Kelly
Rogez-Florent, Tiphaine
Lecoeur, Marie
Danel, Cécile
Regnault, Romain
Vérité, Philippe
Monteil, Christelle
Foulon, Catherine
author_facet Poitou, Kelly
Rogez-Florent, Tiphaine
Lecoeur, Marie
Danel, Cécile
Regnault, Romain
Vérité, Philippe
Monteil, Christelle
Foulon, Catherine
author_sort Poitou, Kelly
collection PubMed
description Gloves represent an essential feature for hand protection because it is a requirement in the professional framework to comply with both hand hygiene standards and the principles of good laboratory practice. Despite their wide use, there is a knowledge gap regarding their composition, including phthalates. The purpose of the present study was to develop two orthogonal methods, GC–MS and HPLC–DAD, for the screening of plasticizers in gloves. Performances of these two methods were compared in terms of ease of use, number of analyzed plasticizers, and sample preparation. The two methods were validated and applied for the identification and quantification of plasticizers in ten gloves made with different materials (vinyl, nitrile, latex, and neoprene). Results revealed the presence of three main ones: DEHP, DEHT, and DINP. Additionally, the contents of plasticizers were extremely variable, depending on the glove material. As expected, the results point out a predominant use of plasticizers in vinyl gloves with an amount that should be of concern. While DEHP is classified as a toxic substance for reproduction 1B, it was, however, quantified in the ten different glove samples studied. This study provides new data regarding the plasticizers’ content in protective gloves, which could be useful for risk assessment.
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spelling pubmed-84722782021-09-28 Analysis of Phthalates and Alternative Plasticizers in Gloves by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–UV Detection: A Comparative Study Poitou, Kelly Rogez-Florent, Tiphaine Lecoeur, Marie Danel, Cécile Regnault, Romain Vérité, Philippe Monteil, Christelle Foulon, Catherine Toxics Article Gloves represent an essential feature for hand protection because it is a requirement in the professional framework to comply with both hand hygiene standards and the principles of good laboratory practice. Despite their wide use, there is a knowledge gap regarding their composition, including phthalates. The purpose of the present study was to develop two orthogonal methods, GC–MS and HPLC–DAD, for the screening of plasticizers in gloves. Performances of these two methods were compared in terms of ease of use, number of analyzed plasticizers, and sample preparation. The two methods were validated and applied for the identification and quantification of plasticizers in ten gloves made with different materials (vinyl, nitrile, latex, and neoprene). Results revealed the presence of three main ones: DEHP, DEHT, and DINP. Additionally, the contents of plasticizers were extremely variable, depending on the glove material. As expected, the results point out a predominant use of plasticizers in vinyl gloves with an amount that should be of concern. While DEHP is classified as a toxic substance for reproduction 1B, it was, however, quantified in the ten different glove samples studied. This study provides new data regarding the plasticizers’ content in protective gloves, which could be useful for risk assessment. MDPI 2021-08-28 /pmc/articles/PMC8472278/ /pubmed/34564351 http://dx.doi.org/10.3390/toxics9090200 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Poitou, Kelly
Rogez-Florent, Tiphaine
Lecoeur, Marie
Danel, Cécile
Regnault, Romain
Vérité, Philippe
Monteil, Christelle
Foulon, Catherine
Analysis of Phthalates and Alternative Plasticizers in Gloves by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–UV Detection: A Comparative Study
title Analysis of Phthalates and Alternative Plasticizers in Gloves by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–UV Detection: A Comparative Study
title_full Analysis of Phthalates and Alternative Plasticizers in Gloves by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–UV Detection: A Comparative Study
title_fullStr Analysis of Phthalates and Alternative Plasticizers in Gloves by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–UV Detection: A Comparative Study
title_full_unstemmed Analysis of Phthalates and Alternative Plasticizers in Gloves by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–UV Detection: A Comparative Study
title_short Analysis of Phthalates and Alternative Plasticizers in Gloves by Gas Chromatography–Mass Spectrometry and Liquid Chromatography–UV Detection: A Comparative Study
title_sort analysis of phthalates and alternative plasticizers in gloves by gas chromatography–mass spectrometry and liquid chromatography–uv detection: a comparative study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472278/
https://www.ncbi.nlm.nih.gov/pubmed/34564351
http://dx.doi.org/10.3390/toxics9090200
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