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Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters

Water-soluble nanoclusters, which are facilely enrichable without changes in the original properties, are highly demanded in many disciplines. In this contribution, a new class of gold nanoclusters (AuNCs) was synthesized using glutathione disulfide (GSSG) as a reducing and capping agent under inter...

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Autores principales: Zhang, Qianqian, Wang, Junhua, Meng, Zhao, Ling, Rui, Ren, Hang, Qin, Weidong, Wu, Zhenglong, Shao, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472339/
https://www.ncbi.nlm.nih.gov/pubmed/34578574
http://dx.doi.org/10.3390/nano11092258
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author Zhang, Qianqian
Wang, Junhua
Meng, Zhao
Ling, Rui
Ren, Hang
Qin, Weidong
Wu, Zhenglong
Shao, Na
author_facet Zhang, Qianqian
Wang, Junhua
Meng, Zhao
Ling, Rui
Ren, Hang
Qin, Weidong
Wu, Zhenglong
Shao, Na
author_sort Zhang, Qianqian
collection PubMed
description Water-soluble nanoclusters, which are facilely enrichable without changes in the original properties, are highly demanded in many disciplines. In this contribution, a new class of gold nanoclusters (AuNCs) was synthesized using glutathione disulfide (GSSG) as a reducing and capping agent under intermittent heating mode. The as-prepared GSSG–AuNCs had a higher quantum yield (4.1%) compared to the conventional glutathione-protected AuNCs (1.8%). Moreover, by simply introducing the GSSG–AuNC solution to acetonitrile at a volume ratio of 1:7, a new bottom phase was formed, in which GSSG–AuNCs could be 400-fold enriched without changes in properties, with a percentage recovery higher than 99%. The enrichment approach did not need additional instruments and was potentially suitable for large-scale enrichment of nanoclusters. Further, density functional theory calculations indicated that the hydrogen bonding between GSSG and acetonitrile plays a key role for the bottom phase formation. Our work suggests that the highly emissive GSSG–AuNCs possess great potential not only in fluorescent measurements but also in other scenarios in which high-concentration AuNCs may be needed, such as catalysis, drug delivery, and electronic and optical industries.
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spelling pubmed-84723392021-09-28 Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters Zhang, Qianqian Wang, Junhua Meng, Zhao Ling, Rui Ren, Hang Qin, Weidong Wu, Zhenglong Shao, Na Nanomaterials (Basel) Article Water-soluble nanoclusters, which are facilely enrichable without changes in the original properties, are highly demanded in many disciplines. In this contribution, a new class of gold nanoclusters (AuNCs) was synthesized using glutathione disulfide (GSSG) as a reducing and capping agent under intermittent heating mode. The as-prepared GSSG–AuNCs had a higher quantum yield (4.1%) compared to the conventional glutathione-protected AuNCs (1.8%). Moreover, by simply introducing the GSSG–AuNC solution to acetonitrile at a volume ratio of 1:7, a new bottom phase was formed, in which GSSG–AuNCs could be 400-fold enriched without changes in properties, with a percentage recovery higher than 99%. The enrichment approach did not need additional instruments and was potentially suitable for large-scale enrichment of nanoclusters. Further, density functional theory calculations indicated that the hydrogen bonding between GSSG and acetonitrile plays a key role for the bottom phase formation. Our work suggests that the highly emissive GSSG–AuNCs possess great potential not only in fluorescent measurements but also in other scenarios in which high-concentration AuNCs may be needed, such as catalysis, drug delivery, and electronic and optical industries. MDPI 2021-08-31 /pmc/articles/PMC8472339/ /pubmed/34578574 http://dx.doi.org/10.3390/nano11092258 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Qianqian
Wang, Junhua
Meng, Zhao
Ling, Rui
Ren, Hang
Qin, Weidong
Wu, Zhenglong
Shao, Na
Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters
title Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters
title_full Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters
title_fullStr Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters
title_full_unstemmed Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters
title_short Glutathione Disulfide as a Reducing, Capping, and Mass-Separating Agent for the Synthesis and Enrichment of Gold Nanoclusters
title_sort glutathione disulfide as a reducing, capping, and mass-separating agent for the synthesis and enrichment of gold nanoclusters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472339/
https://www.ncbi.nlm.nih.gov/pubmed/34578574
http://dx.doi.org/10.3390/nano11092258
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