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Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials
Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472411/ https://www.ncbi.nlm.nih.gov/pubmed/34578878 http://dx.doi.org/10.3390/nu13093001 |
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author | Barkhidarian, Bahareh Roldos, Lucas Iskandar, Michèle M. Saedisomeolia, Ahmad Kubow, Stan |
author_facet | Barkhidarian, Bahareh Roldos, Lucas Iskandar, Michèle M. Saedisomeolia, Ahmad Kubow, Stan |
author_sort | Barkhidarian, Bahareh |
collection | PubMed |
description | Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions. |
format | Online Article Text |
id | pubmed-8472411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84724112021-09-28 Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials Barkhidarian, Bahareh Roldos, Lucas Iskandar, Michèle M. Saedisomeolia, Ahmad Kubow, Stan Nutrients Systematic Review Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions. MDPI 2021-08-28 /pmc/articles/PMC8472411/ /pubmed/34578878 http://dx.doi.org/10.3390/nu13093001 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Barkhidarian, Bahareh Roldos, Lucas Iskandar, Michèle M. Saedisomeolia, Ahmad Kubow, Stan Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials |
title | Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials |
title_full | Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials |
title_fullStr | Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials |
title_full_unstemmed | Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials |
title_short | Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials |
title_sort | probiotic supplementation and micronutrient status in healthy subjects: a systematic review of clinical trials |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472411/ https://www.ncbi.nlm.nih.gov/pubmed/34578878 http://dx.doi.org/10.3390/nu13093001 |
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