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Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 wit...

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Autores principales: Moleon, Maria-Del-Carmen, Martinez-Gomez, Estrella, Flook, Marisa, Peralta-Leal, Andreina, Gallego, Juan Antonio, Sanchez-Gomez, Hortensia, Montilla-Ibañez, Maria Alharilla, Dominguez-Durán, Emilio, Soto-Varela, Andres, Aran, Ismael, Frejo, Lidia, Lopez-Escamez, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472422/
https://www.ncbi.nlm.nih.gov/pubmed/34575163
http://dx.doi.org/10.3390/jcm10184052
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author Moleon, Maria-Del-Carmen
Martinez-Gomez, Estrella
Flook, Marisa
Peralta-Leal, Andreina
Gallego, Juan Antonio
Sanchez-Gomez, Hortensia
Montilla-Ibañez, Maria Alharilla
Dominguez-Durán, Emilio
Soto-Varela, Andres
Aran, Ismael
Frejo, Lidia
Lopez-Escamez, Jose A.
author_facet Moleon, Maria-Del-Carmen
Martinez-Gomez, Estrella
Flook, Marisa
Peralta-Leal, Andreina
Gallego, Juan Antonio
Sanchez-Gomez, Hortensia
Montilla-Ibañez, Maria Alharilla
Dominguez-Durán, Emilio
Soto-Varela, Andres
Aran, Ismael
Frejo, Lidia
Lopez-Escamez, Jose A.
author_sort Moleon, Maria-Del-Carmen
collection PubMed
description Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls.
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spelling pubmed-84724222021-09-28 Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease Moleon, Maria-Del-Carmen Martinez-Gomez, Estrella Flook, Marisa Peralta-Leal, Andreina Gallego, Juan Antonio Sanchez-Gomez, Hortensia Montilla-Ibañez, Maria Alharilla Dominguez-Durán, Emilio Soto-Varela, Andres Aran, Ismael Frejo, Lidia Lopez-Escamez, Jose A. J Clin Med Article Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls. MDPI 2021-09-07 /pmc/articles/PMC8472422/ /pubmed/34575163 http://dx.doi.org/10.3390/jcm10184052 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moleon, Maria-Del-Carmen
Martinez-Gomez, Estrella
Flook, Marisa
Peralta-Leal, Andreina
Gallego, Juan Antonio
Sanchez-Gomez, Hortensia
Montilla-Ibañez, Maria Alharilla
Dominguez-Durán, Emilio
Soto-Varela, Andres
Aran, Ismael
Frejo, Lidia
Lopez-Escamez, Jose A.
Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
title Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
title_full Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
title_fullStr Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
title_full_unstemmed Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
title_short Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
title_sort clinical and cytokine profile in patients with early and late onset meniere disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472422/
https://www.ncbi.nlm.nih.gov/pubmed/34575163
http://dx.doi.org/10.3390/jcm10184052
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