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Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 wit...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472422/ https://www.ncbi.nlm.nih.gov/pubmed/34575163 http://dx.doi.org/10.3390/jcm10184052 |
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author | Moleon, Maria-Del-Carmen Martinez-Gomez, Estrella Flook, Marisa Peralta-Leal, Andreina Gallego, Juan Antonio Sanchez-Gomez, Hortensia Montilla-Ibañez, Maria Alharilla Dominguez-Durán, Emilio Soto-Varela, Andres Aran, Ismael Frejo, Lidia Lopez-Escamez, Jose A. |
author_facet | Moleon, Maria-Del-Carmen Martinez-Gomez, Estrella Flook, Marisa Peralta-Leal, Andreina Gallego, Juan Antonio Sanchez-Gomez, Hortensia Montilla-Ibañez, Maria Alharilla Dominguez-Durán, Emilio Soto-Varela, Andres Aran, Ismael Frejo, Lidia Lopez-Escamez, Jose A. |
author_sort | Moleon, Maria-Del-Carmen |
collection | PubMed |
description | Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls. |
format | Online Article Text |
id | pubmed-8472422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84724222021-09-28 Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease Moleon, Maria-Del-Carmen Martinez-Gomez, Estrella Flook, Marisa Peralta-Leal, Andreina Gallego, Juan Antonio Sanchez-Gomez, Hortensia Montilla-Ibañez, Maria Alharilla Dominguez-Durán, Emilio Soto-Varela, Andres Aran, Ismael Frejo, Lidia Lopez-Escamez, Jose A. J Clin Med Article Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls. MDPI 2021-09-07 /pmc/articles/PMC8472422/ /pubmed/34575163 http://dx.doi.org/10.3390/jcm10184052 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moleon, Maria-Del-Carmen Martinez-Gomez, Estrella Flook, Marisa Peralta-Leal, Andreina Gallego, Juan Antonio Sanchez-Gomez, Hortensia Montilla-Ibañez, Maria Alharilla Dominguez-Durán, Emilio Soto-Varela, Andres Aran, Ismael Frejo, Lidia Lopez-Escamez, Jose A. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
title | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
title_full | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
title_fullStr | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
title_full_unstemmed | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
title_short | Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease |
title_sort | clinical and cytokine profile in patients with early and late onset meniere disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472422/ https://www.ncbi.nlm.nih.gov/pubmed/34575163 http://dx.doi.org/10.3390/jcm10184052 |
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