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H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?

The endothelium controls vascular homeostasis through a delicate balance between secretion of vasodilators and vasoconstrictors. The loss of physiological homeostasis leads to endothelial dysfunction, for which inflammatory events represent critical determinants. In this context, therapeutic approac...

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Detalles Bibliográficos
Autores principales: Gorini, Francesca, Del Turco, Serena, Sabatino, Laura, Gaggini, Melania, Vassalle, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472626/
https://www.ncbi.nlm.nih.gov/pubmed/34572292
http://dx.doi.org/10.3390/biomedicines9091107
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author Gorini, Francesca
Del Turco, Serena
Sabatino, Laura
Gaggini, Melania
Vassalle, Cristina
author_facet Gorini, Francesca
Del Turco, Serena
Sabatino, Laura
Gaggini, Melania
Vassalle, Cristina
author_sort Gorini, Francesca
collection PubMed
description The endothelium controls vascular homeostasis through a delicate balance between secretion of vasodilators and vasoconstrictors. The loss of physiological homeostasis leads to endothelial dysfunction, for which inflammatory events represent critical determinants. In this context, therapeutic approaches targeting inflammation-related vascular injury may help for the treatment of cardiovascular disease and a multitude of other conditions related to endothelium dysfunction, including COVID-19. In recent years, within the complexity of the inflammatory scenario related to loss of vessel integrity, hydrogen sulfide (H(2)S) has aroused great interest due to its importance in different signaling pathways at the endothelial level. In this review, we discuss the effects of H(2)S, a molecule which has been reported to demonstrate anti-inflammatory activity, in addition to many other biological functions related to endothelium and sulfur-drugs as new possible therapeutic options in diseases involving vascular pathobiology, such as in SARS-CoV-2 infection.
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spelling pubmed-84726262021-09-28 H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection? Gorini, Francesca Del Turco, Serena Sabatino, Laura Gaggini, Melania Vassalle, Cristina Biomedicines Review The endothelium controls vascular homeostasis through a delicate balance between secretion of vasodilators and vasoconstrictors. The loss of physiological homeostasis leads to endothelial dysfunction, for which inflammatory events represent critical determinants. In this context, therapeutic approaches targeting inflammation-related vascular injury may help for the treatment of cardiovascular disease and a multitude of other conditions related to endothelium dysfunction, including COVID-19. In recent years, within the complexity of the inflammatory scenario related to loss of vessel integrity, hydrogen sulfide (H(2)S) has aroused great interest due to its importance in different signaling pathways at the endothelial level. In this review, we discuss the effects of H(2)S, a molecule which has been reported to demonstrate anti-inflammatory activity, in addition to many other biological functions related to endothelium and sulfur-drugs as new possible therapeutic options in diseases involving vascular pathobiology, such as in SARS-CoV-2 infection. MDPI 2021-08-28 /pmc/articles/PMC8472626/ /pubmed/34572292 http://dx.doi.org/10.3390/biomedicines9091107 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gorini, Francesca
Del Turco, Serena
Sabatino, Laura
Gaggini, Melania
Vassalle, Cristina
H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?
title H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?
title_full H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?
title_fullStr H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?
title_full_unstemmed H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?
title_short H(2)S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?
title_sort h(2)s as a bridge linking inflammation, oxidative stress and endothelial biology: a possible defense in the fight against sars-cov-2 infection?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472626/
https://www.ncbi.nlm.nih.gov/pubmed/34572292
http://dx.doi.org/10.3390/biomedicines9091107
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