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Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin
The purpose of this study was to evaluate specifically the relationship between glycated haemoglobin (HbA1c) levels and retinal optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in type 1 Diabetes Mellitus (DM). A total of 478 type 1 DM patients and 115 controls were included...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472643/ https://www.ncbi.nlm.nih.gov/pubmed/34573883 http://dx.doi.org/10.3390/diagnostics11091537 |
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author | Bernal-Morales, Carolina Alé-Chilet, Aníbal Martín-Pinardel, Ruben Barraso, Marina Hernández, Teresa Oliva, Cristian Vinagre, Irene Ortega, Emilio Figueras-Roca, Marc Sala-Puigdollers, Anna Gimenez, Marga Esmatjes, Enric Adán, Alfredo Zarranz-Ventura, Javier |
author_facet | Bernal-Morales, Carolina Alé-Chilet, Aníbal Martín-Pinardel, Ruben Barraso, Marina Hernández, Teresa Oliva, Cristian Vinagre, Irene Ortega, Emilio Figueras-Roca, Marc Sala-Puigdollers, Anna Gimenez, Marga Esmatjes, Enric Adán, Alfredo Zarranz-Ventura, Javier |
author_sort | Bernal-Morales, Carolina |
collection | PubMed |
description | The purpose of this study was to evaluate specifically the relationship between glycated haemoglobin (HbA1c) levels and retinal optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in type 1 Diabetes Mellitus (DM). A total of 478 type 1 DM patients and 115 controls were included in a prospective OCTA trial (ClinicalTrials.gov NCT03422965). Subgroup analysis was performed for controls, no diabetic retinopathy (DM-no DR) and DR patients (DM-DR), and HbA1c levels. OCT and OCTA measurements were compared with HbA1c levels (current and previous 5 years). DM-no DR patients with HbA1c levels >7.5% showed lower VD than DM-DR and controls (20.16 vs. 20.22 vs. 20.71, p < 0.05), and showed a significant correlation between HbA1c levels and FAZc (p = 0.04), after adjusting for age, gender, signal strength index, axial length, and DM disease duration. DM-DR patients with HbA1c > 7.5% presented greater CRT than DM-no DR and controls (270.8 vs. 260 vs. 251.1, p < 0.05) and showed a significant correlation between HbA1c and CRT (p = 0.03). In conclusion, greater levels of HbA1c are associated with OCTA changes in DM-no DR patients, and with structural OCT changes in DM-DR patients. The combination of OCTA and OCT measurements and HbA1c levels may be helpful to identify patients at risk of progression to greater stages of the diabetic microvascular disease. |
format | Online Article Text |
id | pubmed-8472643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84726432021-09-28 Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin Bernal-Morales, Carolina Alé-Chilet, Aníbal Martín-Pinardel, Ruben Barraso, Marina Hernández, Teresa Oliva, Cristian Vinagre, Irene Ortega, Emilio Figueras-Roca, Marc Sala-Puigdollers, Anna Gimenez, Marga Esmatjes, Enric Adán, Alfredo Zarranz-Ventura, Javier Diagnostics (Basel) Article The purpose of this study was to evaluate specifically the relationship between glycated haemoglobin (HbA1c) levels and retinal optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in type 1 Diabetes Mellitus (DM). A total of 478 type 1 DM patients and 115 controls were included in a prospective OCTA trial (ClinicalTrials.gov NCT03422965). Subgroup analysis was performed for controls, no diabetic retinopathy (DM-no DR) and DR patients (DM-DR), and HbA1c levels. OCT and OCTA measurements were compared with HbA1c levels (current and previous 5 years). DM-no DR patients with HbA1c levels >7.5% showed lower VD than DM-DR and controls (20.16 vs. 20.22 vs. 20.71, p < 0.05), and showed a significant correlation between HbA1c levels and FAZc (p = 0.04), after adjusting for age, gender, signal strength index, axial length, and DM disease duration. DM-DR patients with HbA1c > 7.5% presented greater CRT than DM-no DR and controls (270.8 vs. 260 vs. 251.1, p < 0.05) and showed a significant correlation between HbA1c and CRT (p = 0.03). In conclusion, greater levels of HbA1c are associated with OCTA changes in DM-no DR patients, and with structural OCT changes in DM-DR patients. The combination of OCTA and OCT measurements and HbA1c levels may be helpful to identify patients at risk of progression to greater stages of the diabetic microvascular disease. MDPI 2021-08-25 /pmc/articles/PMC8472643/ /pubmed/34573883 http://dx.doi.org/10.3390/diagnostics11091537 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bernal-Morales, Carolina Alé-Chilet, Aníbal Martín-Pinardel, Ruben Barraso, Marina Hernández, Teresa Oliva, Cristian Vinagre, Irene Ortega, Emilio Figueras-Roca, Marc Sala-Puigdollers, Anna Gimenez, Marga Esmatjes, Enric Adán, Alfredo Zarranz-Ventura, Javier Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin |
title | Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin |
title_full | Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin |
title_fullStr | Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin |
title_full_unstemmed | Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin |
title_short | Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin |
title_sort | optical coherence tomography angiography in type 1 diabetes mellitus. report 4: glycated haemoglobin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472643/ https://www.ncbi.nlm.nih.gov/pubmed/34573883 http://dx.doi.org/10.3390/diagnostics11091537 |
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