Cargando…

Antibiotic Use during the COVID-19 Pandemic in a Tertiary Hospital with an Ongoing Antibiotic Stewardship Program

During the recent pandemic, the fact that the clinical manifestation of COVID-19 may be indistinguishable from bacterial infection, as well as concerns of bacterial co-infection, have been associated with an increased use of antibiotics. The objective of this study was to assess the effect of target...

Descripción completa

Detalles Bibliográficos
Autores principales: Henig, Oryan, Kehat, Orli, Meijer, Suzy E., Chikly, Amanda, Weiss-Meilik, Ahuva, Egoz, Eyal, Ben-Ami, Ronen, Paran, Yael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472687/
https://www.ncbi.nlm.nih.gov/pubmed/34572638
http://dx.doi.org/10.3390/antibiotics10091056
_version_ 1784574798245920768
author Henig, Oryan
Kehat, Orli
Meijer, Suzy E.
Chikly, Amanda
Weiss-Meilik, Ahuva
Egoz, Eyal
Ben-Ami, Ronen
Paran, Yael
author_facet Henig, Oryan
Kehat, Orli
Meijer, Suzy E.
Chikly, Amanda
Weiss-Meilik, Ahuva
Egoz, Eyal
Ben-Ami, Ronen
Paran, Yael
author_sort Henig, Oryan
collection PubMed
description During the recent pandemic, the fact that the clinical manifestation of COVID-19 may be indistinguishable from bacterial infection, as well as concerns of bacterial co-infection, have been associated with an increased use of antibiotics. The objective of this study was to assess the effect of targeted antibiotic stewardship programs (ASP) on the use of antibiotics in designated COVID-19 departments and to compare it to the antibiotic use in the equivalent departments in the same periods of 2018 and 2019. Antibiotic consumption was assessed as days of treatment (DOT) per 1000 patient days (PDs). The COVID-19 pandemic was divided into three periods (waves) according to the pandemic dynamics. The proportion of patients who received at least one antibiotic was significantly lower in COVID-19 departments compared to equivalent departments in 2018 and 2019 (Wave 2: 30.2% vs. 45.6% and 44.9%, respectively; Wave 3: 30.5% vs. 47.8% and 50.1%, respectively, p < 0.001). The DOT/1000PDs in every COVID-19 wave was lower than during similar periods in 2018 and 2019 (179-282 DOT/1000PDs vs. 452-470 DOT/1000PDs vs. 426-479 DOT/1000PDs, respectively). Moreover, antibiotic consumption decreased over time during the pandemic. In conclusion, a strong ASP is effective in restricting antibiotic consumption, particularly for COVID-19 which is a viral disease that may mimic bacterial sepsis but has a low rate of concurrent bacterial infection.
format Online
Article
Text
id pubmed-8472687
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84726872021-09-28 Antibiotic Use during the COVID-19 Pandemic in a Tertiary Hospital with an Ongoing Antibiotic Stewardship Program Henig, Oryan Kehat, Orli Meijer, Suzy E. Chikly, Amanda Weiss-Meilik, Ahuva Egoz, Eyal Ben-Ami, Ronen Paran, Yael Antibiotics (Basel) Brief Report During the recent pandemic, the fact that the clinical manifestation of COVID-19 may be indistinguishable from bacterial infection, as well as concerns of bacterial co-infection, have been associated with an increased use of antibiotics. The objective of this study was to assess the effect of targeted antibiotic stewardship programs (ASP) on the use of antibiotics in designated COVID-19 departments and to compare it to the antibiotic use in the equivalent departments in the same periods of 2018 and 2019. Antibiotic consumption was assessed as days of treatment (DOT) per 1000 patient days (PDs). The COVID-19 pandemic was divided into three periods (waves) according to the pandemic dynamics. The proportion of patients who received at least one antibiotic was significantly lower in COVID-19 departments compared to equivalent departments in 2018 and 2019 (Wave 2: 30.2% vs. 45.6% and 44.9%, respectively; Wave 3: 30.5% vs. 47.8% and 50.1%, respectively, p < 0.001). The DOT/1000PDs in every COVID-19 wave was lower than during similar periods in 2018 and 2019 (179-282 DOT/1000PDs vs. 452-470 DOT/1000PDs vs. 426-479 DOT/1000PDs, respectively). Moreover, antibiotic consumption decreased over time during the pandemic. In conclusion, a strong ASP is effective in restricting antibiotic consumption, particularly for COVID-19 which is a viral disease that may mimic bacterial sepsis but has a low rate of concurrent bacterial infection. MDPI 2021-08-31 /pmc/articles/PMC8472687/ /pubmed/34572638 http://dx.doi.org/10.3390/antibiotics10091056 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Henig, Oryan
Kehat, Orli
Meijer, Suzy E.
Chikly, Amanda
Weiss-Meilik, Ahuva
Egoz, Eyal
Ben-Ami, Ronen
Paran, Yael
Antibiotic Use during the COVID-19 Pandemic in a Tertiary Hospital with an Ongoing Antibiotic Stewardship Program
title Antibiotic Use during the COVID-19 Pandemic in a Tertiary Hospital with an Ongoing Antibiotic Stewardship Program
title_full Antibiotic Use during the COVID-19 Pandemic in a Tertiary Hospital with an Ongoing Antibiotic Stewardship Program
title_fullStr Antibiotic Use during the COVID-19 Pandemic in a Tertiary Hospital with an Ongoing Antibiotic Stewardship Program
title_full_unstemmed Antibiotic Use during the COVID-19 Pandemic in a Tertiary Hospital with an Ongoing Antibiotic Stewardship Program
title_short Antibiotic Use during the COVID-19 Pandemic in a Tertiary Hospital with an Ongoing Antibiotic Stewardship Program
title_sort antibiotic use during the covid-19 pandemic in a tertiary hospital with an ongoing antibiotic stewardship program
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472687/
https://www.ncbi.nlm.nih.gov/pubmed/34572638
http://dx.doi.org/10.3390/antibiotics10091056
work_keys_str_mv AT henigoryan antibioticuseduringthecovid19pandemicinatertiaryhospitalwithanongoingantibioticstewardshipprogram
AT kehatorli antibioticuseduringthecovid19pandemicinatertiaryhospitalwithanongoingantibioticstewardshipprogram
AT meijersuzye antibioticuseduringthecovid19pandemicinatertiaryhospitalwithanongoingantibioticstewardshipprogram
AT chiklyamanda antibioticuseduringthecovid19pandemicinatertiaryhospitalwithanongoingantibioticstewardshipprogram
AT weissmeilikahuva antibioticuseduringthecovid19pandemicinatertiaryhospitalwithanongoingantibioticstewardshipprogram
AT egozeyal antibioticuseduringthecovid19pandemicinatertiaryhospitalwithanongoingantibioticstewardshipprogram
AT benamironen antibioticuseduringthecovid19pandemicinatertiaryhospitalwithanongoingantibioticstewardshipprogram
AT paranyael antibioticuseduringthecovid19pandemicinatertiaryhospitalwithanongoingantibioticstewardshipprogram