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Albumin Fusion at the N-Terminus or C-Terminus of HM-3 Leads to Improved Pharmacokinetics and Bioactivities

HM-3, an integrin antagonist, exhibits anti-tumor biological responses and therefore has potential as a therapeutic polypeptide. However, the clinical applications of HM-3 are limited by its short half-life. In this study, we genetically fused human serum albumin (HSA) to the N or C-terminus of HM-3...

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Detalles Bibliográficos
Autores principales:	Li, Ting, Zhang, Han-Zi, Ge, Guang-Fei, Yue, Zhao-Rong, Wang, Ru-Yue, Zhang, Qian, Gu, Yan, Song, Mei-Juan, Li, Wen-Bo, Ma, Min-Zhi, Wang, Mei-Zhu, Yang, Hui, Li, Yang, Li, Hong-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472738/ https://www.ncbi.nlm.nih.gov/pubmed/34572270 http://dx.doi.org/10.3390/biomedicines9091084

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