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Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study

There is little evidence regarding the association between serum vitamin B6 concentration and subsequent mortality. We aimed to evaluate the association of serum vitamin B6 concentration with all-cause, cardiovascular disease (CVD), and cancer mortality in the general population using data from the...

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Autores principales: Yang, Donghui, Liu, Yan, Wang, Yafeng, Ma, Yudiyang, Bai, Jianjun, Yu, Chuanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472743/
https://www.ncbi.nlm.nih.gov/pubmed/34578855
http://dx.doi.org/10.3390/nu13092977
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author Yang, Donghui
Liu, Yan
Wang, Yafeng
Ma, Yudiyang
Bai, Jianjun
Yu, Chuanhua
author_facet Yang, Donghui
Liu, Yan
Wang, Yafeng
Ma, Yudiyang
Bai, Jianjun
Yu, Chuanhua
author_sort Yang, Donghui
collection PubMed
description There is little evidence regarding the association between serum vitamin B6 concentration and subsequent mortality. We aimed to evaluate the association of serum vitamin B6 concentration with all-cause, cardiovascular disease (CVD), and cancer mortality in the general population using data from the National Health and Nutrition Examination Survey (NHANES). Our study examined 12,190 adults participating in NHANES from 2005 to 2010 in the United States. The mortality status was linked to National Death Index (NDI) records up to 31 December 2015. Pyridoxal 5′-phosphate (PLP) is the biologically active form of vitamin B6. Vitamin B6 status was defined as deficient (PLP < 20 nmol/L), insufficient (PLP ≥ 20.0 and <30.0 nmol/L), and sufficient (PLP ≥ 30.0 nmol/L). We established Cox proportional-hazards models to estimate the associations of categorized vitamin B6 concentration and log-transformed PLP concentration with all-cause and cause-specific mortality by calculating hazard ratios (HRs) and 95% confidence intervals (95%CIs). In our study, serum vitamin B6 was sufficient in 70.6% of participants, while 12.8% of the subjects were deficient in vitamin B6. During follow-up, a total of 1244 deaths were recorded, including 294 cancer deaths and 235 CVD deaths. After multivariate adjustment in Cox regression, participants with higher serum vitamin B6 had a 15% (HR = 0.85, 95%CI = 0.77, 0.93) reduced risk of all-cause mortality and a 19% (HR = 0.81, 95%CI = 0.68, 0.98) reduced risk for CVD mortality for each unit increment in natural log-transformed PLP. A higher log-transformed PLP was not significantly associated with a lower risk for cancer mortality. Compared with sufficient vitamin B6, deficient (HR = 1.37, 95%CI = 1.17, 1.60) and insufficient (HR = 1.19, 95%CI = 1.02, 1.38) vitamin B6 level were significantly associated with a higher risk for all-cause mortality. There was no significant association for cause-specific mortality. Participants with higher levels of vitamin B6 had a lower risk for all-cause mortality. These findings suggest that maintaining a sufficient level of serum vitamin B6 may lower the all-cause mortality risk in the general population.
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spelling pubmed-84727432021-09-28 Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study Yang, Donghui Liu, Yan Wang, Yafeng Ma, Yudiyang Bai, Jianjun Yu, Chuanhua Nutrients Article There is little evidence regarding the association between serum vitamin B6 concentration and subsequent mortality. We aimed to evaluate the association of serum vitamin B6 concentration with all-cause, cardiovascular disease (CVD), and cancer mortality in the general population using data from the National Health and Nutrition Examination Survey (NHANES). Our study examined 12,190 adults participating in NHANES from 2005 to 2010 in the United States. The mortality status was linked to National Death Index (NDI) records up to 31 December 2015. Pyridoxal 5′-phosphate (PLP) is the biologically active form of vitamin B6. Vitamin B6 status was defined as deficient (PLP < 20 nmol/L), insufficient (PLP ≥ 20.0 and <30.0 nmol/L), and sufficient (PLP ≥ 30.0 nmol/L). We established Cox proportional-hazards models to estimate the associations of categorized vitamin B6 concentration and log-transformed PLP concentration with all-cause and cause-specific mortality by calculating hazard ratios (HRs) and 95% confidence intervals (95%CIs). In our study, serum vitamin B6 was sufficient in 70.6% of participants, while 12.8% of the subjects were deficient in vitamin B6. During follow-up, a total of 1244 deaths were recorded, including 294 cancer deaths and 235 CVD deaths. After multivariate adjustment in Cox regression, participants with higher serum vitamin B6 had a 15% (HR = 0.85, 95%CI = 0.77, 0.93) reduced risk of all-cause mortality and a 19% (HR = 0.81, 95%CI = 0.68, 0.98) reduced risk for CVD mortality for each unit increment in natural log-transformed PLP. A higher log-transformed PLP was not significantly associated with a lower risk for cancer mortality. Compared with sufficient vitamin B6, deficient (HR = 1.37, 95%CI = 1.17, 1.60) and insufficient (HR = 1.19, 95%CI = 1.02, 1.38) vitamin B6 level were significantly associated with a higher risk for all-cause mortality. There was no significant association for cause-specific mortality. Participants with higher levels of vitamin B6 had a lower risk for all-cause mortality. These findings suggest that maintaining a sufficient level of serum vitamin B6 may lower the all-cause mortality risk in the general population. MDPI 2021-08-27 /pmc/articles/PMC8472743/ /pubmed/34578855 http://dx.doi.org/10.3390/nu13092977 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Donghui
Liu, Yan
Wang, Yafeng
Ma, Yudiyang
Bai, Jianjun
Yu, Chuanhua
Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study
title Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study
title_full Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study
title_fullStr Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study
title_full_unstemmed Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study
title_short Association of Serum Vitamin B6 with All-Cause and Cause-Specific Mortality in a Prospective Study
title_sort association of serum vitamin b6 with all-cause and cause-specific mortality in a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472743/
https://www.ncbi.nlm.nih.gov/pubmed/34578855
http://dx.doi.org/10.3390/nu13092977
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